Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TFEB/TFE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TFEB/TFE3 Parallel Activation Drives Coordinated Organelle C | 0.727 | neurodegeneration | How do different organelle-specific auto |
| TFEB-Dependent Lysosome Biogenesis | 0.690 | neurodegeneration | How does controlled lysosomal membrane p |
| Impaired TFEB/TFE3 Nuclear Translocation Due to mTORC1 Hyper | 0.578 | neurodegeneration | What mechanisms underlie neuronal resist |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| AMPK promotes TFEB transcriptional activity through dephosphorylation at both MT [PMID:41661247] | Negoita F, Fraguas Bringas C, Hellberg K | Autophagy | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TFEB/TFE3 in their description or question text
No additional research found