Hypothesis Comparison

graph TD
    A["C1QA Gene
Expression"]
    B["C1q Complex
Formation"]
    C["Synaptic Tagging
for Elimination"]
    D["C3 Convertase
Activation"]
    E["C3b Opsonin
Deposition"]
    F["Microglial
Activation"]
    G["CR3 Receptor
Binding"]
    H["Synaptic
Engulfment"]
    I["Normal Synaptic
Pruning"]
    J["Age-Related
C1QA Upregulation"]
    K["Excessive Synaptic
Loss"]
    L["Neuronal Circuit
Dysfunction"]
    M["Cognitive
Decline"]
    N["C1QA Inhibition
Therapy"]
    O["Microglial
Modulation"]
    P["Synaptic
Protection"]

    A -->|"normal expression"| B
    B -->|"recognizes weak synapses"| C
    C -->|"activates cascade"| D
    D -->|"generates"| E
    E -->|"opsonizes synapses"| G
    F -->|"expresses"| G
    G -->|"phagocytic signal"| H
    H -->|"controlled elimination"| I
    A -->|"aging and pathology"| J
    J -->|"enhanced tagging"| C
    J -->|"hyperactivation"| F
    H -->|"excessive pruning"| K
    K -->|"circuit disruption"| L
    L -->|"functional impairment"| M
    N -->|"reduces activity"| A
    O -->|"modulates response"| F
    N -->|"preserves connectivity"| P
    O -->|"prevents over-pruning"| P

    classDef normal fill:#4fc3f7
    classDef therapeutic fill:#81c784
    classDef pathology fill:#ef5350
    classDef outcome fill:#ffd54f
    classDef molecular fill:#ce93d8

    class A,B,C,D,E,I molecular
    class F,G,H normal
    class J,K,L pathology
    class M outcome
    class N,O,P therapeutic

graph TD
    subgraph Disease["Pathological State"]
        A["Neurodegeneration Trigger"] -->|"upregulates"| B["C1QA Gene Expression"]
        B -->|"produces"| C["C1q Hexameric Complex"]
        C -->|"binds to"| D["Synaptic Eat-Me Signals"]
        D -->|"includes"| E["Phosphatidylserine and Amyloid-beta"]
        C -->|"activates"| F["Classical Complement Cascade"]
        F -->|"generates"| G["C3 Convertase Formation"]
        G -->|"produces"| H["C3b Opsonization"]
        H -->|"recruits"| I["Microglial CR3 Receptors"]
        I -->|"triggers"| J["Synaptic Phagocytosis"]
    end
    
    subgraph Therapy["C1q Mimetic Decoy Intervention"]
        K["C1q Mimetic Decoy Molecule"] -->|"competes with"| C
        K -->|"blocks"| D
        L["Therapeutic Administration"] -->|"delivers"| K
        M["Decoy Sequestration"] -->|"prevents"| F
    end
    
    subgraph Outcome["Clinical Endpoints"]
        N["Synaptic Preservation"] -->|"maintains"| O["Cognitive Function"]
        P["Reduced Neuroinflammation"] -->|"improves"| Q["Neurological Outcomes"]
        R["Biomarker Monitoring"] -->|"tracks"| N
    end
    
    K -->|"reduces"| J
    M -->|"leads to"| N
    M -->|"results in"| P
    
    style A fill:#ef5350,stroke:#333,color:#000
    style B fill:#ce93d8,stroke:#333,color:#000
    style C fill:#ef5350,stroke:#333,color:#000
    style D fill:#ef5350,stroke:#333,color:#000
    style E fill:#ef5350,stroke:#333,color:#000
    style F fill:#ef5350,stroke:#333,color:#000
    style G fill:#4fc3f7,stroke:#333,color:#000
    style H fill:#4fc3f7,stroke:#333,color:#000
    style I fill:#ef5350,stroke:#333,color:#000
    style J fill:#ef5350,stroke:#333,color:#000
    style K fill:#81c784,stroke:#333,color:#000
    style L fill:#81c784,stroke:#333,color:#000
    style M fill:#81c784,stroke:#333,color:#000
    style N fill:#ffd54f,stroke:#333,color:#000
    style O fill:#ffd54f,stroke:#333,color:#000
    style P fill:#ffd54f,stroke:#333,color:#000
    style Q fill:#ffd54f,stroke:#333,color:#000
    style R fill:#4fc3f7,stroke:#333,color:#000