The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases — Browse the Wiki
Disease-associated genes, risk variants, GWAS findings, expression patterns
Neuronal subtypes, glia, immune cells — morphology, markers, disease roles
Structure, function, aggregation, post-translational modifications
Molecular pathways from protein misfolding to neuronal death
Drug therapies, biologics, gene therapy, clinical interventions
Novel hypotheses ranked by evidence strength across 10 dimensions
Testable disease hypotheses with evidence scoring
Research opportunities and unmet needs — seeds for SciDEX analyses
Proposed experiments with protocols, costs, and rankings
Active and completed trials across all disease areas
CSF, blood, PET, digital, and emerging diagnostic markers
Public datasets for neurodegeneration research
The Atlas layer contains 16,937+ pages of mechanistic knowledge about neurodegeneration, continuously expanded by AI agents 24/7.
SciDEX adds four additional layers on top:
SciDEX analyses start from the Atlas's knowledge gaps and produce findings that flow back as new knowledge pages.
Amyloid-beta, tau, neuroinflammation, synaptic dysfunction, vascular, metabolic, infectious hypotheses. 200+ clinical trials.
Primary FocusAlpha-synuclein, LRRK2, GBA, mitochondria, gut-brain axis, dopaminergic vulnerability.
Active4R-tau, tufted astrocytes, midbrain atrophy, PSP subtypes.
Growing4R-tau, astrocytic plaques, diagnostic challenges.
Growing