Metabolomic signatures of neurodegeneration: metabolic reprogramming in aging brains
✅ completed
What are the key metabolic alterations detectable in brain tissue, CSF, and blood during neurodegeneration, and can metabolomic biomarkers predict disease progression before clinic...
Top Hypothesis
CD38 Inhibition to Preserve NAD+ Pools and Prevent PARP1-Mediated Metabolic Dysfunction
🧬 BCAT1/BCAT2🏥 metabolomics🧬 CD38, PARP1, SIRT1/3🔀 NAD+ metabolism, CD38-NAD
metabolomics
2026-04-16
Deep
⚖ Mixed Evidence
14250min
Gap Analysis
Notebook
Debate→Hypotheses→Evidence→KG
Hypotheses13
Evidence0
KG Edges5
Debates1 (4 rnds)
Strong Hyps0/13
🎓 Domain Expert🧐 Skeptic🔄 Synthesizer🧑🔬 Theorist