What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic A1 vs neuroprotective A2 phenotypes?
Analysis ID: SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04 | Domain: neuroinflammation | Status: failed | Created: 2026-04-14T07:55:48.214009
Knowledge Graph: 2 edges — View JSON
Top Hypotheses (2 total)
#1 C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop
0.596
C3AR1, C3, NFKB1
## C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop
### Complement Cascade and Neurotoxic Astrocyte Induction
The complement system is a central mediator of immune surveil
#2 Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization
0.593
AHR, CYP1A1, NFKB1, IL6
# AhR Activation by Microbiome Metabolites Promotes A2 Polarization: A Mechanistic Hypothesis for Gut-Brain Neuroprotection
## Hypothesis Summary
This hypothesis proposes that gut microbiota-derived