{"nodes":[{"id":"neuroinflammation","type":"disease","has_wiki":true,"wiki_url":"/wiki/mechanisms-pd-neuroinflammation","wiki_entity":"Neuroinflammation in PD"},{"id":"C3AR1, C3, NFKB1","type":"gene"},{"id":"AHR, CYP1A1, NFKB1, IL6","type":"gene"}],"edges":[{"source_id":"C3AR1, C3, NFKB1","source_type":"gene","target_id":"neuroinflammation","target_type":"disease","relation":"promoted: C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop","evidence_strength":0.596,"evidence_sources":"[\"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04\", \"{'claim': 'Transcriptome analysis demonstrates C3/C3aR/NF-\\u03baB signaling induces A1 astrocytes after ischemic stroke', 'pmid': '38713438'}\", \"{'claim': 'Complement C1q complex enriched in astrocyte-related gene set (GO:0062167)', 'pmid': 'NA'}\", \"{'claim': 'SASP-Mediated Complement Cascade Amplification identified as established mechanism (confidence: 0.70)', 'pmid': 'NA'}\", \"{'claim': 'NF-\\u03baB complex detected in STRING gene set (GO:0071159)', 'pmid': 'NA'}\", \"{'claim': 'C3AR1 is a 7-transmembrane GPCR - among most drug-friendly target architectures in biology', 'pmid': 'NA'}\"]","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","created_at":"2026-04-14T14:55:48-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"c3ar1,_c3,_nfkb1","target_canonical_id":"ent-proc-f21faf77","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-48b29b62","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"AHR, CYP1A1, NFKB1, IL6","source_type":"gene","target_id":"neuroinflammation","target_type":"disease","relation":"promoted: Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization","evidence_strength":0.593,"evidence_sources":"[\"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04\", \"{'claim': 'Microbiome-derived indole-3-lactic acid reduces amyloidopathy via AhR activation', 'pmid': '39197546'}\", \"{'claim': 'AhR modulates stroke-induced astrogliosis and neurogenesis', 'pmid': '31606043'}\", \"{'claim': 'Indole-3-propionic acid inhibits astrocyte inflammation via AhR/NF-\\u03baB/MAPK axis', 'pmid': '41663028'}\", \"{'claim': 'Gut-brain axis represents novel therapeutic angle not targeted by competitors', 'pmid': 'NA'}\", \"{'claim': 'AhR is a ligand-activated transcription factor with established pharmacology', 'pmid': 'NA'}\"]","analysis_id":"SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04","created_at":"2026-04-14T15:03:49-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"ahr,_cyp1a1,_nfkb1,_il6","target_canonical_id":"ent-proc-f21faf77","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-423b50a1","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":2,"total_nodes":3,"has_more":false}}