SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
Analysis ID: analysis-SEAAD-20260402 | Domain: neurodegeneration | Status: completed | Created: 2026-04-02 18:29:58
Knowledge Graph: 65 edges — View JSON
Top Hypotheses (5 total)
#1 Cell-Type Specific TREM2 Upregulation in DAM Microglia
0.519
TREM2
TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) shows marked upregulation in disease-associated microglia (DAM) within the SEA-AD Brain Cell Atlas. Analysis of middle temporal gyrus single-nu
#2 GFAP-Positive Reactive Astrocyte Subtype Delineation
0.518
GFAP
GFAP (Glial Fibrillary Acidic Protein) upregulation in the SEA-AD dataset marks reactive astrocyte populations in the middle temporal gyrus with a log2 fold change of +2.8 — the highest differential e
#3 APOE Isoform Expression Across Glial Subtypes
0.476
APOE
APOE (Apolipoprotein E) shows significant upregulation (log2FC = +1.8) in the SEA-AD dataset, with expression patterns varying dramatically across astrocyte and microglial subtypes in the middle tempo
#4 Excitatory Neuron Vulnerability via SLC17A7 Downregulation
0.445
SLC17A7
SLC17A7 (also known as VGLUT1, vesicular glutamate transporter 1) shows significant downregulation (log2FC = -1.7) in the SEA-AD dataset, specifically in layer 3 and layer 5 excitatory neurons of the
#5 Complement C1QA Spatial Gradient in Cortical Layers
0.428
C1QA
C1QA, the initiating protein of the classical complement cascade, shows upregulation in the SEA-AD dataset with a layer-specific spatial gradient across cortical neurons in the middle temporal gyrus.