What are the physiological functions of BACE1 beyond APP processing that could cause side effects from therapeutic inhibition?

Analysis ID: SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2 | Domain: neurodegeneration | Status: failed | Created: 2026-04-15T11:17:39.198768

Top Hypotheses (1 total)

#1 BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Interneuron Hypofunction

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NRG1/ERBB4

Neuregulin-1 (NRG1) type III cleavage by BACE1 is essential for PV interneuron maturation and their proper inhibitory output onto pyramidal neurons. Therapeutic BACE1 inhibition blocks NRG1 processing

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