What upstream mechanisms trigger p53 activation specifically in response to poly(PR) dipeptide repeats?

Analysis ID: SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2 | Domain: neurodegeneration | Status: failed | Created: 2026-04-15T09:38:39.085404

Top Hypotheses (1 total)

#1 PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation

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PARP1

# PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation ## Mechanistic Foundation The GGGGCC hexanucleotide repeat expansion in the C9orf72 gene constitutes the most co

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