Analysis ID: SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32 | Domain: neurodegeneration | Status: failed | Created: 2026-04-15T07:54:51.820729
#1 SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction
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SGMS1, BECN1
Elevated SGMS1 activity increases sphingomyelin levels in neuronal membranes, disrupting autophagosome-lysosome fusion and preventing lysosomal degradation of BACE1. This leads to BACE1 accumulation i