Why does autophagy inhibition improve neuronal survival when autophagy is typically neuroprotective?

Analysis ID: SDA-2026-04-15-gap-pubmed-20260411-075356-20920528 | Domain: neurodegeneration | Status: failed | Created: 2026-04-15T03:30:31.310158

Top Hypotheses (1 total)

#1 Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy

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# Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy ## Mechanistic Foundation The lysosome represents a critical regulatory hub in neuronal homeostasis, serving as the primary

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