How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and activity in synaptic vs non-synaptic lipid rafts?
Analysis ID: SDA-2026-04-15-gap-debate-20260410-112819-e40e0fa2 | Domain: neurodegeneration | Status: completed | Created: 2026-04-15T21:50:04.233905
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Top Hypotheses (1 total)
#1 SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regulation
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SMPD1
Acid sphingomyelinase (ASM/SMPD1) is elevated in AD brains, generating ceramide accumulation in membrane microdomains. SMPD1 inhibition using FIASMA drugs (amitriptyline) or direct inhibitors (OLX-070