Analysis ID: SDA-2026-04-15-gap-debate-20260410-112607-0a3749ea | Domain: neurodegeneration | Status: completed | Created: 2026-04-15T19:29:13.658392
#1 CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds
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APOE, CLU
Clusterin (CLU) and APOE exhibit opposing functions in amyloid homeostasis—CLU primarily inhibits fibril formation while APOE shows context-dependent effects. Differential expression patterns in APOE4