What is the temporal sequence of TREM2 signaling transition from protective to inflammatory during aging?
Analysis ID: SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f | Domain: neuroimmunology | Status: completed | Created: 2026-04-15T15:53:38.254549
Knowledge Graph: 2 edges — View JSON
Top Hypotheses (2 total)
#1 CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification
0.674
sTREM2/membrane-TREM2/ADAM10
# CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification
## Mechanistic Foundations of TREM2 Biology
The triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-sur
#2 TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation
0.563
TREM2/ACAT1/LXR
# TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation: A Unifying Mechanism for Microglial Dysfunction in Alzheimer's Disease
## The Mechanistic Core: A Ligand-Binding Defect with Systemic