Analysis ID: SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3 | Domain: neurodegeneration | Status: completed | Created: 2026-04-15T15:03:34.678196
#1 C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Elimination in Alzheimer's Disease
0.497
C1QA, C1QB
Microglial C1Q/C3 activation drives synaptic pruning through complement-mediated elimination. PV interneurons receive disproportionate complement-mediated pruning of their excitatory inputs (PC→PV syn