Analysis ID: SDA-2026-04-14-gap-pubmed-20260410-193701-11582758 | Domain: neurodegeneration | Status: failed | Created: 2026-04-14T16:11:15.482097
#1 CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target
0.548
CLU-APOE-TREM2 axis (LXR/RXR pathway)
Simultaneous Modulation of CLU, APOE, and TREM2 Restores Lipid Metabolism and Reduces Complement-Mediated Neuroinflammation. Since CLU shares a 0.991 STRING confidence interaction with APOE and 0.954