Analysis ID: SDA-2026-04-14-gap-pubmed-20260410-193244-89904941 | Domain: neurodegeneration | Status: failed | Created: 2026-04-14T15:21:23.583818
#1 LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Deficits
0.505
NR1H2 (LXRβ)
APOE4 impairs the ability of oligodendrocytes to efflux and distribute cholesterol for myelin sheath synthesis. LXRβ (NR1H2) serves as the master transcriptional regulator of cholesterol efflux genes