How do P/Q channel deficits paradoxically increase thalamic excitability despite impairing neurotransmitter release?

Analysis ID: SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3 | Domain: synaptic biology | Status: failed | Created: 2026-04-14T05:19:34.416277

Top Hypotheses (1 total)

#1 HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Deficiency

0.526

HCN1

# HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Deficiency ## Mechanistic Framework The thalamocortical circuit represents a critical nexus between cortical and subcort

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