What is the molecular mechanism by which oligodendroglial MCT1 disruption causes axon damage and neuron loss?

Analysis ID: SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5 | Domain: neurodegeneration | Status: failed | Created: 2026-04-13T18:51:13.780662

Knowledge Graph: 2 edges — View JSON

Top Hypotheses (2 total)

#1 SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-Dependent Axon Degeneration

0.614

SARM1, NMNAT2

# SARM1-Mediated NAD⁺ Depletion as Terminal Executor of MCT1-Dependent Axon Degeneration ## Background and Conceptual Framework Axon degeneration represents a convergent pathological endpoint across

#2 Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction

0.569

PVALB, SLC16A1/MCT1

**Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction in Neurodegeneration** The selective vulnerability of parvalbumin-expressing (PV+) interneurons repres

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