Analysis ID: SDA-2026-04-13-gap-pubmed-20260410-165527-8256a071 | Domain: neurodegeneration | Status: failed | Created: 2026-04-13T16:33:38.738578
#1 TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation
0.520
TBK1
TBK1 mutations impair autophagic clearance of protein aggregates, triggering cellular senescence in neurons and glia. The resulting SASP cytokine release (including IFN-β) activates microglia, upregul