Analysis ID: SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b | Domain: neuroinflammation | Status: failed | Created: 2026-04-13T10:27:16.367397
#1 Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determines AQP4 Tolerance Fate
0.612
AHR, IL10, TNFRSF13B, TIGIT, FOXP3
Microbiome-derived AHR ligands induce AQP4-tolerant Breg cells via tryptophan metabolite signaling. AHR activation by microbiome-derived tryptophan metabolites (e.g., kynurenine, indole derivatives) i
#2 IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral Tolerance Through Macrophage Reprogramming
0.601
IL10, CSF1R, CD40
B10 cell-derived IL-10 suppresses AQP4-specific pro-inflammatory responses via CSF1R-mediated myeloid reprogramming. Regulatory B cells (B10 cells) expressing IL-10 represent the primary mechanism by