Analysis ID: SDA-2026-04-13-gap-pubmed-20260410-110327-26e1d6c7 | Domain: neurodegeneration | Status: failed | Created: 2026-04-13T09:35:25.233416
#1 MITF Acts as the Primary Transcriptional Effector Downstream of HDAC1/2 Deletion, Driving the DAM2 Lysosomal Program Through De-repression of Phagocytic Enhancers
0.444
MITF
HDAC1/2 normally maintain homeostatic microglia by deacetylating H3K9 and H3K27 at enhancers of MITF and its CLEAR network target genes (LAMP1, CTSD, GBA, HEXB). Upon HDAC1/2 deletion, enhancers accum
#2 HDAC2-Specific Repression of PU.1 Pioneer Factor Target Sites Suppresses the IL-33/ST2-Phagocytic Axis; HDAC2 Deletion Specifically Unmasks These Enhancers
0.415
HDAC2
HDAC2 is preferentially recruited to PU.1 (SPI1) pioneer factor-occupied enhancers via the NuRD co-repressor complex. Under homeostasis, HDAC2 deacetylates H3K27 at PU.1 targets governing IL1RL1 (ST2)