RNA binding protein dysregulation across ALS FTD AD

Analysis ID: SDA-2026-04-13-gap-20260410-172514 | Domain: neurodegeneration | Status: failed | Created: 2026-04-13T03:46:51.169625

Knowledge Graph: 2 edges — View JSON

Top Hypotheses (2 total)

#1 Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD Spectrum

0.664

STMN2 (stathmin-2), PTBP1/PTBP2

TDP-43 loss-of-function causes inclusion of a poison exon in STMN2 mRNA, leading to motor neuropathy and contributing to hippocampal axonal dysfunction. Splice-switching oligonucleotides or small mole

#2 TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gamma Oscillations

0.577

TARDBP (TDP-43) / cryptic splice sites in GABAergic transcripts (DLGAP1, KCNQ2, GABRA1)

# TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gamma Oscillations in Alzheimer's Disease ## Mechanistic Foundation TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA-binding protein th

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