How does APOE4's beneficial immune function reconcile with its established role as the strongest AD risk factor?

Analysis ID: SDA-2026-04-12-gap-pubmed-20260410-184126-b2c3e2e8 | Domain: neurodegeneration | Status: completed | Created: 2026-04-12T19:17:33.787365

Top Hypotheses (1 total)

#1 H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance

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TREM2

Pharmacological activation of TREM2 signaling to shift APOE4-associated microglia from complement-mediated synaptic engulfment toward amyloid-phagocytic phenotype. Leverages strong APOE-TREM2 protein

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