What is the relative contribution of connexin-43 gap junctions vs tunneling nanotubes to mitochondrial transfer?
Analysis ID: SDA-2026-04-12-gap-debate-20260410-113038-57244485 | Domain: cell biology | Status: completed | Created: 2026-04-12T21:35:29.372687
Knowledge Graph: 1 edges — View JSON
Top Hypotheses (2 total)
#1 Context-Dependent Cx43 Modulation Based on Disease Stage
0.579
GJA1 (Cx43) - context-dependent
# Context-Dependent Cx43 Modulation Based on Disease Stage: A Mechanistic Framework for Stage-Specific Connexin-Targeting Therapeutics
The emerging understanding of Connexin-43 (Cx43) biology in
#2 TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between SASP and Synaptic Pruning
0.548
TNF, IL1B → GJA1 → C1Q/C3
# TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between SASP and Synaptic Pruning
## Mechanism of Action
The hypothesis posits a hierarchically organized signaling cascade in which senescent