Metabolic reprogramming in neurodegenerative disease
Analysis ID: SDA-2026-04-02-gap-v2-5d0e3052 | Domain: neurodegeneration | Status: completed | Created: 2026-04-02T00:51:58.562166
Knowledge Graph: 28 edges — View JSON
Top Hypotheses (3 total)
#1 The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
0.398
TFEB
**Background and Rationale**
The cellular quality control system represents one of the most critical determinants of neuronal survival and longevity. Among the key players in this system, the transcr
#2 Brain Insulin Resistance with Glucose Transporter Dysfunction
0.398
GLUT3/GLUT4
Brain Insulin Resistance with Glucose Transporter Dysfunction proposes that neuronal insulin signaling failure — a central metabolic feature of Alzheimer's disease often called "type 3 diabetes" — dri
#3 The Glial Ketone Metabolic Shunt Hypothesis
0.398
HMGCS2
The Glial Ketone Metabolic Shunt Hypothesis proposes that reactive astrocytes in neurodegenerative disease aberrantly upregulate ketone body synthesis (ketogenesis), creating a metabolic steal syndrom