{"questions":[{"id":"open_question-therapeutics-convection-enhanced-delivery-3b82e104","artifact_type":"open_question","title":"Combination therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-convection-enhanced-delivery-0abc85d6","artifact_type":"open_question","title":"Smart catheters","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-gba-gene-therapy-96a10c72","artifact_type":"open_question","title":"Self-complementary AAV","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-gba-gene-therapy-1f0a4152","artifact_type":"open_question","title":"Enhanced capsids","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-gba-gene-therapy-40e0672f","artifact_type":"open_question","title":"Regulatable expression","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-als-therapeutics-9b6ce13d","artifact_type":"open_question","title":"Pharmacogenomics","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-nad-precursor-therapy-49402d63","artifact_type":"open_question","title":"Combination therapies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-debate-therapeutics-fa1031c7","artifact_type":"open_question","title":"Does combined maresin analog plus senolytic agent treatment eliminate senescent microglia while preserving non-senescent cells, or does it cause unacceptable off-target toxicity that limits its therap","quality_score":0.625,"metadata":{},"created_at":"2026-04-28T06:05:58.916619+00:00","updated_at":"2026-04-28T06:05:58.916619+00:00"},{"id":"open_question-debate-therapeutics-9b1615a0","artifact_type":"open_question","title":"Can extracellular vesicle-based mitochondrial transfer therapies achieve sufficient brain penetration and neuronal specificity through systemic delivery using current LAMP2B targeting approaches?","quality_score":0.55,"metadata":{},"created_at":"2026-04-28T06:08:49.683262+00:00","updated_at":"2026-04-28T06:08:49.683262+00:00"},{"id":"open_question-55a48569-00c3-4dab-8536-5d5af71d9025","artifact_type":"open_question","title":"What is the optimal dosing regimen for chronic AD treatment?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:28:54.582449+00:00","updated_at":"2026-04-26T03:28:54.582449+00:00"},{"id":"open_question-86940f59-55eb-4716-98ed-3f84c87d4838","artifact_type":"open_question","title":"Optimal dosing**: What is the optimal dose for efficacy while maintaining safety?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:27:03.116442+00:00","updated_at":"2026-04-26T03:27:03.116442+00:00"},{"id":"open_question-70d21bf8-c412-44e2-80f0-64e9d9a44092","artifact_type":"open_question","title":"Clinical outcomes**: Will tau reduction translate to cognitive benefit?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:27:03.181982+00:00","updated_at":"2026-04-26T03:27:03.181982+00:00"},{"id":"open_question-a177410d-7578-4131-85b7-be2e036d251e","artifact_type":"open_question","title":"Long-term safety**: What is the optimal duration of treatment?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:25:55.517617+00:00","updated_at":"2026-04-26T03:25:55.517617+00:00"},{"id":"open_question-therapeutics-senolytic-agents-7472f155","artifact_type":"open_question","title":"Combination trials","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-anti-tau-immunotherapies-836cfc66","artifact_type":"open_question","title":"Mechanistic understanding","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-senolytic-agents-787945bb","artifact_type":"open_question","title":"Larger AD trials","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-d2807210-3ef4-4f47-b504-68c5bf277816","artifact_type":"open_question","title":"Patient selection**: Which patients are most likely to respond?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:29:10.604572+00:00","updated_at":"2026-04-26T03:29:10.604572+00:00"},{"id":"open_question-therapeutics-exosome-based-therapeutics-e941c470","artifact_type":"open_question","title":"Targeting moieties","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-exosome-based-therapeutics-ba0d7929","artifact_type":"open_question","title":"Cargo loading optimization","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-iron-chelation-therapy-parkinsons-e4da1606","artifact_type":"open_question","title":"Phase III Trials","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-nusinersen-f3993622","artifact_type":"open_question","title":"Risdiplam ([risdiplam](/therapeutics/risdiplam))","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-nusinersen-51f78559","artifact_type":"open_question","title":"Novel ASO chemistries","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-deep-brain-stimulation-ea3e915e","artifact_type":"open_question","title":"Closed-loop systems","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-targeted-protein-stabilization-therapy-88d0ca18","artifact_type":"open_question","title":"Gene therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-targeted-protein-stabilization-therapy-2f1bff4a","artifact_type":"open_question","title":"Protein engineering","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-targeted-protein-stabilization-therapy-cde58f3e","artifact_type":"open_question","title":"Multi-target approaches","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-targeted-protein-stabilization-therapy-30221c46","artifact_type":"open_question","title":"Precision medicine","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-llps-modulator-therapy-4beb6a9d","artifact_type":"open_question","title":"Mitochondrial condensates","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-llps-modulator-therapy-f241516e","artifact_type":"open_question","title":"Nucleolar stress","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-llps-modulator-therapy-3512c2e0","artifact_type":"open_question","title":"LLPS modulators + autophagy enhancers","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-exosome-therapy-neurodegeneration-7935bc8f","artifact_type":"open_question","title":"Brain-organoid derived exosomes","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-exosome-therapy-neurodegeneration-cdff63b2","artifact_type":"open_question","title":"Exosome-based combination therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-exosome-therapy-neurodegeneration-dc457e24","artifact_type":"open_question","title":"MRI-guided delivery","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-dopamine-agonists-81dc86fc","artifact_type":"open_question","title":"Glutamate antagonists","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-orexin-receptor-modulators-b88e3d30","artifact_type":"open_question","title":"OX2R-selective agonists","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-dopamine-agonists-d5ffe38d","artifact_type":"open_question","title":"Long-acting formulations","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-dopamine-agonists-7e14217e","artifact_type":"open_question","title":"Continuous delivery","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-endocannabinoid-system-modulation-therapy-11df971e","artifact_type":"open_question","title":"CB1 positive allosteric modulators (PAMs)","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-endocannabinoid-system-modulation-therapy-9a983d85","artifact_type":"open_question","title":"Combination therapy protocols","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-targeted-protein-degradation-protacs-37e40a94","artifact_type":"open_question","title":"Combination with other modalities","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-lundbeck-genentech-bispecific-brain-shuttle-86160a65","artifact_type":"open_question","title":"Modular platforms","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-ampa-receptor-antagonists-62b5ed0d","artifact_type":"open_question","title":"Positive allosteric modulators","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-ampa-receptor-antagonists-de3a3c1a","artifact_type":"open_question","title":"Subunit-selective compounds","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-cannabinoid-receptor-modulation-therapy-adb20a00","artifact_type":"open_question","title":"Combination approaches","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-car-t-cell-therapy-parkinsons-6478e186","artifact_type":"open_question","title":"Dementia with Lewy bodies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-orexin-receptor-modulators-3b82e104","artifact_type":"open_question","title":"Combination therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-florbetapir-62882240","artifact_type":"open_question","title":"Automated Quantification","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-florbetapir-f32ae0b7","artifact_type":"open_question","title":"Epidemiology","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-immunotherapy-4f643b93","artifact_type":"open_question","title":"Prevention trials","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-immunotherapy-1436ee5f","artifact_type":"open_question","title":"Biomarker-guided treatment","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-immunotherapy-17016332","artifact_type":"open_question","title":"Subcutaneous formulations","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-spinal-cord-stimulation-parkinsons-5d199d03","artifact_type":"open_question","title":"Novel Targets","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-spinal-cord-stimulation-parkinsons-d390a47f","artifact_type":"open_question","title":"Wireless Systems","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-protein-misfolding-inhibitors-neurodegeneration-6737ef5a","artifact_type":"open_question","title":"Personalized medicine","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-irisin-therapy-8d16c7f3","artifact_type":"open_question","title":"Mechanism Elucidation","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-irisin-therapy-49bb81fd","artifact_type":"open_question","title":"Therapeutic Optimization","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-irisin-therapy-4316f45d","artifact_type":"open_question","title":"Clinical Translation","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-bbb-penetrant-antibodies-8aece859","artifact_type":"open_question","title":"Trojan horse liposomes","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-optogenetics-neurodegeneration-e1744df9","artifact_type":"open_question","title":"Gene delivery:","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-optogenetics-neurodegeneration-545b594e","artifact_type":"open_question","title":"Wireless systems:","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-optogenetics-neurodegeneration-a45e55c1","artifact_type":"open_question","title":"Closed-loop:","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-optogenetics-neurodegeneration-dd2dca16","artifact_type":"open_question","title":"Combination:","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-icaritin-parkinsons-gper-24c5bcee","artifact_type":"open_question","title":"Biomarker development","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-icaritin-parkinsons-gper-2d90f8d4","artifact_type":"open_question","title":"Formulation optimization","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-tau-immunotherapy-2a385928","artifact_type":"open_question","title":"Small molecule tau modulators","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-tau-immunotherapy-10c3712a","artifact_type":"open_question","title":"Combination regimens","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-sglt2-inhibitors-parkinsons-46c9c115","artifact_type":"open_question","title":"Mechanistic studies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-sglt2-inhibitors-parkinsons-e7904cbd","artifact_type":"open_question","title":"Disease stage optimization","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-alpha-synuclein-immunotherapy-4892d91a","artifact_type":"open_question","title":"Early intervention","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-neurotrophic-factor-therapies-86056cd4","artifact_type":"open_question","title":"Cleavage-resistant pro-neurotrophins","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-cxcl12-cxcr4-axis-modulator-therapy-f5742e37","artifact_type":"open_question","title":"biased agonists","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-glp-1-receptor-agonists-5a4008fd","artifact_type":"open_question","title":"Intranasal delivery","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-glp-1-receptor-agonists-edc487b9","artifact_type":"open_question","title":"CNS-selective analogs","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-tau-gene-therapy-46dbd443","artifact_type":"open_question","title":"Epigenetic Modulation","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-dulaglutide-neurodegeneration-08e15e03","artifact_type":"open_question","title":"Observational Studies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-trem2-agonists-142dd821","artifact_type":"open_question","title":"Multiple sclerosis","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-trehalose-neurodegeneration-836085b7","artifact_type":"open_question","title":"Genetic stratification","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-mesenchymal-stem-cell-therapy-parkinsons-f61491fa","artifact_type":"open_question","title":"Combination Approaches","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-protacs-neurodegeneration-c7184c29","artifact_type":"open_question","title":"Patient stratification","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-alpha-lipoic-acid-neurodegeneration-01888053","artifact_type":"open_question","title":"Combination formulations","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-alpha-lipoic-acid-neurodegeneration-e1bf042f","artifact_type":"open_question","title":"Blood Sugar Effects","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-mtor-inhibitor-therapy-parkinsons-49af04a4","artifact_type":"open_question","title":"Selective mTORC1 inhibitors","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-crispr-gene-editing-parkinsons-4a74e5aa","artifact_type":"open_question","title":"Gene integration","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-etalanetug-e2814-567dca16","artifact_type":"open_question","title":"Patient selection","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-etalanetug-e2814-3208e8a1","artifact_type":"open_question","title":"Combination potential","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-lysosomal-lipid-trafficking-cbs-psp-3b82e104","artifact_type":"open_question","title":"Combination therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-lysosomal-lipid-trafficking-cbs-psp-24c5bcee","artifact_type":"open_question","title":"Biomarker development","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-lysosomal-lipid-trafficking-cbs-psp-88d0ca18","artifact_type":"open_question","title":"Gene therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-convection-enhanced-delivery-981398b3","artifact_type":"open_question","title":"Stem cell delivery","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-alpha-synuclein-reduction-therapies-49402d63","artifact_type":"open_question","title":"Combination therapies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-section-117-disease-modification-endpoints-cbs-psp-a9796122","artifact_type":"open_question","title":"Composite AI endpoints","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-section-117-disease-modification-endpoints-cbs-psp-8184434e","artifact_type":"open_question","title":"Physiological biomarkers","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-circadian-rhythm-modulation-e3c7704e","artifact_type":"open_question","title":"Optimal timing and dosing","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-circadian-rhythm-modulation-f7296d5d","artifact_type":"open_question","title":"Combination strategies","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-therapeutics-circadian-rhythm-modulation-836085b7","artifact_type":"open_question","title":"Genetic stratification","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"},{"id":"open_question-d87a10fe-295b-451b-aa93-ae5be2df8018","artifact_type":"open_question","title":"Can digital adherence tools and caregiver coaching improve real-world effect size?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:29:45.698276+00:00","updated_at":"2026-04-26T03:29:45.698276+00:00"},{"id":"open_question-d225fd5b-9c43-4f3d-a65f-bc86a47b4a9d","artifact_type":"open_question","title":"How can meal-pattern intervention trials be designed for advanced dysphagic populations without high attrition?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:29:45.639965+00:00","updated_at":"2026-04-26T03:29:45.639965+00:00"},{"id":"open_question-57d92900-991a-40fd-ae83-adee01d10241","artifact_type":"open_question","title":"Are there genotype-dependent responses (for example, [APOE](/proteins/apoe)-stratified effects)?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:29:45.582528+00:00","updated_at":"2026-04-26T03:29:45.582528+00:00"},{"id":"open_question-bc6b7907-a972-4877-aeae-128bfdb95f46","artifact_type":"open_question","title":"Which component drives most benefit: lipid quality, polyphenol load, fiber diversity, or adherence consistency?","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T03:29:45.519840+00:00","updated_at":"2026-04-26T03:29:45.519840+00:00"},{"id":"open_question-therapeutics-convection-enhanced-delivery-88d0ca18","artifact_type":"open_question","title":"Gene therapy","quality_score":0.5,"metadata":{},"created_at":"2026-04-26T00:54:30.013560+00:00","updated_at":"2026-04-26T00:54:30.013560+00:00"}],"total":1016,"limit":100,"offset":0,"returned":100,"sort":"importance_elo","field":"therapeutics"}