% Bibliography for hypothesis h-seaad-v4-26ba859b
% Title: ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia
% Generated: 2026-04-29T01:27:25Z

@article{pmid41498558,
  title = {Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease link for early detection.},
  author = {Singh P, Rath SL},
  journal = {Journal of Alzheimer's disease : JAD},
  year = {2026},
  pmid = {41498558},
  doi = {10.1177/13872877251411331},
  url = {https://pubmed.ncbi.nlm.nih.gov/41498558/},
}

@article{pmid41662890,
  title = {NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke via mediating neddylation of NRF2.},
  author = {Rao W, Huang Y, Li J, Chen Q, Sun J et al.},
  journal = {J Stroke Cerebrovasc Dis},
  year = {2026},
  pmid = {41662890},
  doi = {doi: 10.1016/j.jstrokecerebrovasdis.2026.108582},
  url = {https://pubmed.ncbi.nlm.nih.gov/41662890/},
}

@article{pmid41662914,
  title = {Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent ferroptosis.},
  author = {["Xin R", "Zhang J", "Zhang Y", "Dai M", "Li Y", "Ma J", "Shen M", "Shen C", "Chen Z", "Zhu Q"]},
  journal = {Free radical biology & medicine},
  year = {2026},
  pmid = {41662914},
  doi = {10.1016/j.freeradbiomed.2026.02.011},
}

@article{pmid41714892,
  title = {Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal Shock Wave Therapy through the Integrin-β1/NRF2 Axis.},
  author = {Lin D, Li K, Kuang W, Chen Z, Zhang M},
  journal = {World J Mens Health},
  year = {2026},
  pmid = {41714892},
  doi = {doi: 10.5534/wjmh.250222},
  url = {https://pubmed.ncbi.nlm.nih.gov/41714892/},
}

@article{pmid41763496,
  title = {Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mechanisms.},
  author = {Che L, Zhu L, Zhou L, Zhou Y},
  journal = {Biochim Biophys Acta Rev Cancer},
  year = {2026},
  pmid = {41763496},
  doi = {doi: 10.1016/j.bbcan.2026.189566},
  url = {https://pubmed.ncbi.nlm.nih.gov/41763496/},
}

@article{pmid41860570,
  title = {B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis.},
  author = {Chien Y, Xia R, Zhou D, Ai Y, Wu L et al.},
  journal = {Hepatol Commun},
  year = {2026},
  pmid = {41860570},
  doi = {doi: 10.1097/HC9.0000000000000920},
  url = {https://pubmed.ncbi.nlm.nih.gov/41860570/},
}

@article{pmid41862445,
  title = {FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.},
  author = {Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M},
  journal = {Cell death & disease},
  year = {2026},
  pmid = {41862445},
  doi = {10.1038/s41419-026-08570-y},
  url = {https://pubmed.ncbi.nlm.nih.gov/41862445/},
}

@article{pmid41873334,
  title = {Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Mediated Ferritinophagy Through Dual Antioxidant and Anti-Inflammatory Effects.},
  author = {Song C, Wu X, Chen C, Shen B, He Y, Liu F, Chen F, Fu Z, Liu Z},
  journal = {Drug design, development and therapy},
  year = {2026},
  pmid = {41873334},
  doi = {10.2147/DDDT.S575321},
  url = {https://pubmed.ncbi.nlm.nih.gov/41873334/},
}

@article{pmid41895086,
  title = {Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pathway to inhibit ferroptosis.},
  author = {Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, Gao Y, Tao K, Wang H, Xi X},
  journal = {Tissue & cell},
  year = {2026},
  pmid = {41895086},
  doi = {10.1016/j.tice.2026.103496},
  url = {https://pubmed.ncbi.nlm.nih.gov/41895086/},
}

@article{pmid41902795,
  title = {Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis via the SIRT3/AMPK signaling pathway.},
  author = {Gao C, Liu B, Zhang R, Tian J, Xin H},
  journal = {Toxicology mechanisms and methods},
  year = {2026},
  pmid = {41902795},
  doi = {10.1080/15376516.2026.2627917},
  url = {https://pubmed.ncbi.nlm.nih.gov/41902795/},
}

@article{pmid41924362,
  title = {Ferroptosis and microglial polarization in retinal vein occlusion: pathological mechanisms and therapeutic strategies.},
  author = {Xu J, Sun M, Wang C, Ju P, Guan XD, Xie LK, Hao XF},
  journal = {International journal of ophthalmology},
  year = {2026},
  pmid = {41924362},
  doi = {10.18240/ijo.2026.04.21},
  url = {https://pubmed.ncbi.nlm.nih.gov/41924362/},
}

@article{pmid39103533,
  title = {Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.},
  author = {Johnston KG, Berackey BT, Tran KM, Gelber A, Yu Z, MacGregor GR, Mukamel EA, Tan Z, Green KN, Xu X},
  journal = {Molecular psychiatry},
  year = {2025},
  pmid = {39103533},
  doi = {10.1038/s41380-024-02651-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/39103533/},
}

@article{pmid39495531,
  title = {Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.},
  author = {Ayton S, Barton D, Brew B, Brodtmann A, Clarnette R, Desmond P, Devos D, Ellis KA, Fazlollahi A, Fradette C, Goh AMY, Kalinowski P, Kyndt C, Lai R, Lim YY, Maruff P, O'Brien TJ, Rowe C, Salvado O, Schofield PW, Spino M, Tricta F, Wagen A, Williams R, Woodward M, Bush AI},
  journal = {JAMA neurology},
  year = {2025},
  pmid = {39495531},
  doi = {10.1001/jamaneurol.2024.3733},
  url = {https://pubmed.ncbi.nlm.nih.gov/39495531/},
}

@article{pmid39510074,
  title = {Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis.},
  author = {["Zha Xu", "Liu Xicheng", "Wei Mengping", "Huang Huanwei", "Cao Jiaqi"]},
  journal = {Cell metabolism},
  year = {2025},
  pmid = {39510074},
  doi = {10.1016/j.cmet.2024.10.006},
}

@article{pmid40271063,
  title = {Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway.},
  author = {Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu K, Yu X, Zhu J, Liu C, Zhu Q},
  journal = {Frontiers in pharmacology},
  year = {2025},
  pmid = {40271063},
  doi = {10.3389/fphar.2025.1588375},
  url = {https://pubmed.ncbi.nlm.nih.gov/40271063/},
}

@article{pmid40442550,
  title = {Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Amyloid Precursor Protein Processing in Neuronal Cell Lines.},
  author = {Wongjaikam S, Siengdee P, Somnus A, Govitrapong P},
  journal = {Neurotoxicity research},
  year = {2025},
  pmid = {40442550},
  doi = {10.1007/s12640-025-00747-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/40442550/},
}

@article{pmid40640358,
  title = {Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.},
  author = {Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhang M, Zhou J, Wang F},
  journal = {Scientific reports},
  year = {2025},
  pmid = {40640358},
  doi = {10.1038/s41598-025-09563-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/40640358/},
}

@article{pmid40803604,
  title = {Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy.},
  author = {He Z, Liu S, Shi W, Yang Y, Wang J, Wang J, Yin J, Shen S, Zhou D, Li J},
  journal = {Brain research},
  year = {2025},
  pmid = {40803604},
  doi = {10.1016/j.brainres.2025.149885},
  url = {https://pubmed.ncbi.nlm.nih.gov/40803604/},
}

@article{pmid41394684,
  title = {Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer's disease models.},
  author = {Montesinos J, Yun TD, Salomón-Cruz ID, Agudelo-Castrillón SC, Uceda M, Ferre AC, Anton-Barros C, Gomez-Lopez N, Agrawal RR, Larrea D, Velasco KR, Fernàndez-Bernal A, Benitez E, Zhu X, Schon EA, Lopera F, Cardona-Gomez GP, Area-Gomez E},
  journal = {bioRxiv : the preprint server for biology},
  year = {2025},
  pmid = {41394684},
  doi = {10.1101/2025.11.25.690197},
  url = {https://pubmed.ncbi.nlm.nih.gov/41394684/},
}

@article{pmid41918944,
  title = {Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cutaneous melanoma.},
  author = {Paria S, Lapides R, Saravi B, Rajagopal A, Torrez AM, Kölblinger P, Wang-Evers M, Manstein D, Navarini AA, Lazar P, Kemény LV, Sarek G, Adhikari K, Németh IB, Roider E},
  journal = {Frontiers in medicine},
  year = {2025},
  pmid = {41918944},
  doi = {10.3389/fmed.2025.1553961},
  url = {https://pubmed.ncbi.nlm.nih.gov/41918944/},
}

@article{pmid37869901,
  title = {Diabetes, antidiabetic medications and risk of dementia: A systematic umbrella review and meta-analysis.},
  author = {Kuate Defo A, Bakula V, Pisaturo A, Labos C, Wing SS, Daskalopoulou SS},
  journal = {Diabetes, obesity & metabolism},
  year = {2024},
  pmid = {37869901},
  doi = {10.1111/dom.15331},
  url = {https://pubmed.ncbi.nlm.nih.gov/37869901/},
}

@article{pmid36581060,
  title = {ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons.},
  author = {Bouchaoui H, Mahoney-Sanchez L, Garçon G, Berdeaux O, Alleman LY, Devos D, Duce JA, Devedjian JC},
  journal = {Free radical biology & medicine},
  year = {2023},
  pmid = {36581060},
  doi = {10.1016/j.freeradbiomed.2022.12.086},
  url = {https://pubmed.ncbi.nlm.nih.gov/36581060/},
}

@article{pmid37351177,
  title = {High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization.},
  author = {Feng S, Wu C, Zou P, Deng Q, Chen Z, Li M, Zhu L, Li F, Liu TC, Duan R, Yang L},
  journal = {Theranostics},
  year = {2023},
  pmid = {37351177},
  doi = {10.7150/thno.81951},
  url = {https://pubmed.ncbi.nlm.nih.gov/37351177/},
}

@article{pmid37605362,
  title = {Ferroptosis of Microglia in Aging Human White Matter Injury.},
  author = {Adeniyi PA, Gong X, MacGregor E, Degener-O'Brien K, McClendon E, Garcia M, Romero O, Russell J, Srivastava T, Miller J, Keene CD, Back SA},
  journal = {Annals of neurology},
  year = {2023},
  pmid = {37605362},
  doi = {10.1002/ana.26770},
  url = {https://pubmed.ncbi.nlm.nih.gov/37605362/},
}

@article{pmid37657967,
  title = {Therapeutic inhibition of ferroptosis in neurodegenerative disease.},
  author = {["Ryan S", "Ugalde C", "Rolland A", "Skidmore J", "Devos D", "Hammond T"]},
  journal = {Trends in pharmacological sciences},
  year = {2023},
  pmid = {37657967},
  doi = {10.1016/j.tips.2023.07.007},
}

@article{pmid37824655,
  title = {Transcriptomic cytoarchitecture reveals principles of human neocortex organization},
  author = {Jorstad NL, Close J, Johansen N, Yanny AM, Barkan ER, Travaglini KJ, Bertagnolli D, Campos J, Casper T, Crichton K, Dee N, Ding SL, Gelfand E, Goldy J, Hirschstein D, Kiick K, Kroll M, Kunst M, Lathia K, Long B, Martin N, McMillen D, Pham T, Rimorin C, Ruiz A, Shapovalova N, Shehata S, Siletti K, Somasundaram S, Sulc J},
  journal = {Science},
  year = {2023},
  pmid = {37824655},
  doi = {10.1126/science.adf6812},
  url = {https://repository.cshl.edu/id/eprint/41277/1/science.adf6812.pdf},
}

@article{pmid34936886,
  title = {Human embryonic genome activation initiates at the one-cell stage.},
  author = {Asami M, Lam BYH, Ma MK, Rainbow K, Braun S, VerMilyea MD, Yeo GSH, Perry ACF},
  journal = {Cell stem cell},
  year = {2022},
  pmid = {34936886},
  doi = {10.1016/j.stem.2021.11.012},
  url = {https://pubmed.ncbi.nlm.nih.gov/34936886/},
}

@article{pmid35216678,
  title = {CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4.},
  author = {Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gijón M, Shah YM, Zou W},
  journal = {Cancer cell},
  year = {2022},
  pmid = {35216678},
  doi = {10.1016/j.ccell.2022.02.003},
  url = {https://pubmed.ncbi.nlm.nih.gov/35216678/},
}

@article{pmid35325805,
  title = {Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.},
  author = {Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L},
  journal = {Redox biology},
  year = {2022},
  pmid = {35325805},
  doi = {10.1016/j.redox.2022.102292},
  url = {https://pubmed.ncbi.nlm.nih.gov/35325805/},
}

@article{pmid35625641,
  title = {Cerebral Iron Deposition in Neurodegeneration.},
  author = {Dusek P, Hofer T, Alexander J, Roos PM, Aaseth JO},
  journal = {Biomolecules},
  year = {2022},
  pmid = {35625641},
  doi = {10.3390/biom12050714},
  url = {https://pubmed.ncbi.nlm.nih.gov/35625641/},
}

@article{pmid35691251,
  title = {How neurons die in Alzheimer's disease: Implications for neuroinflammation.},
  author = {["Mangalmurti Aman", "Lukens John R"]},
  journal = {Current opinion in neurobiology},
  year = {2022},
  pmid = {35691251},
  doi = {10.1016/j.conb.2022.102575},
}

@article{pmid35931085,
  title = {Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration.},
  author = {Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, Thion MS, Zhang XM, Kong WT, Deloger M, Fontes V, Weiner A, Ee R, Dress R, Hang JW, Balachander A, Chakarov S, Malleret B, Dunsmore G, Cexus O, Chen J, Garel S, Dutertre CA, Amit I, Kipnis J, Ginhoux F},
  journal = {Immunity},
  year = {2022},
  pmid = {35931085},
  doi = {10.1016/j.immuni.2022.07.004},
  url = {https://pubmed.ncbi.nlm.nih.gov/35931085/},
}

@article{pmid36297287,
  title = {FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.},
  author = {Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, Tang Y, Zheng Y, Wu T},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year = {2022},
  pmid = {36297287},
  doi = {10.3390/ph15101177},
  url = {https://pubmed.ncbi.nlm.nih.gov/36297287/},
}

@article{pmid36357676,
  title = {Acute and postacute sequelae associated with SARS-CoV-2 reinfection.},
  author = {Bowe B, Xie Y, Al-Aly Z},
  journal = {Nature medicine},
  year = {2022},
  pmid = {36357676},
  doi = {10.1038/s41591-022-02051-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/36357676/},
}

@article{pmid33959477,
  title = {Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status.},
  author = {Toh JWT, Ferguson AL, Spring KJ, Mahajan H, Palendira U},
  journal = {World journal of clinical oncology},
  year = {2021},
  pmid = {33959477},
  doi = {10.5306/wjco.v12.i4.238},
  url = {https://pubmed.ncbi.nlm.nih.gov/33959477/},
}

@article{pmid34292312,
  title = {Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?},
  author = {Chen Y, Colonna M},
  journal = {The Journal of experimental medicine},
  year = {2021},
  pmid = {34292312},
  doi = {10.1084/jem.20202717},
  url = {https://pubmed.ncbi.nlm.nih.gov/34292312/},
}

@article{pmid31722396,
  title = {A maximum likelihood approach to electronic health record phenotyping using positive and unlabeled patients.},
  author = {Zhang L, Ding X, Ma Y, Muthu N, Ajmal I, Moore JH, Herman DS, Chen J},
  journal = {Journal of the American Medical Informatics Association : JAMIA},
  year = {2020},
  pmid = {31722396},
  doi = {10.1093/jamia/ocz170},
  url = {https://pubmed.ncbi.nlm.nih.gov/31722396/},
}

@article{pmid30606613,
  title = {Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.},
  author = {Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA},
  journal = {Neuron},
  year = {2019},
  pmid = {30606613},
  doi = {10.1016/j.neuron.2018.12.006},
  url = {https://pubmed.ncbi.nlm.nih.gov/30606613/},
}

@article{pmid33444476,
  title = {Prediction of putative small molecules for manipulation of enriched signalling pathways in hESC-derived early cardiovascular progenitors by bioinformatics analysis.},
  author = {Vahdat S, Bakhshandeh B},
  journal = {IET systems biology},
  year = {2019},
  pmid = {33444476},
  doi = {10.1049/iet-syb.2018.5037},
  url = {https://pubmed.ncbi.nlm.nih.gov/33444476/},
}

@article{pmid27842070,
  title = {ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.},
  author = {Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M},
  journal = {Nature chemical biology},
  year = {2017},
  pmid = {27842070},
  doi = {10.1038/nchembio.2239},
  url = {https://pubmed.ncbi.nlm.nih.gov/27842070/},
}

@article{pmid28602351,
  title = {A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.},
  author = {["Keren-Shaul H", "Spinrad A", "Weiner A", "Matcovitch-Natan O", "Dvir-Szternfeld R", "Ulland TK", "David E", "Baruch K", "Lara-Astaiso D", "Toth B", "Itzkovitz S", "Colonna M", "Schwartz M", "Amit I"]},
  journal = {Cell},
  year = {2017},
  pmid = {28602351},
  doi = {10.1016/j.cell.2017.05.018},
  url = {https://pubmed.ncbi.nlm.nih.gov/28602351/},
}

@article{pmid28777374,
  title = {High mobility group A1 protein modulates autophagy in cancer cells.},
  author = {Conte A, Paladino S, Bianco G, Fasano D, Gerlini R, Tornincasa M, Renna M, Fusco A, Tramontano D, Pierantoni GM},
  journal = {Cell death and differentiation},
  year = {2017},
  pmid = {28777374},
  doi = {10.1038/cdd.2017.117},
  url = {https://pubmed.ncbi.nlm.nih.gov/28777374/},
}

@article{pmid26890777,
  title = {Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer's Dementia Using Quantitative Susceptibility Mapping Imaging.},
  author = {Moon Y, Han SH, Moon WJ},
  journal = {Journal of Alzheimer's disease : JAD},
  year = {2016},
  pmid = {26890777},
  doi = {10.3233/JAD-151037},
  url = {https://pubmed.ncbi.nlm.nih.gov/26890777/},
}

@article{pmid25524661,
  title = {"When I was no longer able to see and walk, that is when I was affected most": experiences of disability in people living with HIV in South Africa.},
  author = {Hanass-Hancock J, Myezwa H, Nixon SA, Gibbs A},
  journal = {Disability and rehabilitation},
  year = {2015},
  pmid = {25524661},
  doi = {10.3109/09638288.2014.993432},
  url = {https://pubmed.ncbi.nlm.nih.gov/25524661/},
}

@article{pmid26400084,
  title = {Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.},
  author = {Chen L, Hambright WS, Na R, Ran Q},
  journal = {The Journal of biological chemistry},
  year = {2015},
  pmid = {26400084},
  doi = {10.1074/jbc.M115.680090},
  url = {https://pubmed.ncbi.nlm.nih.gov/26400084/},
}