% Bibliography for hypothesis h-f3fb3b91
% Title: Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming
% Generated: 2026-04-28T13:32:43Z

@article{pmid40659086,
  title = {Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.},
  author = {Li Z, Tan D, Lin J, Zhang T, Liu B et al.},
  journal = {J Adv Res},
  year = {2026},
  pmid = {40659086},
  doi = {doi: 10.1016/j.jare.2025.07.013},
  url = {https://pubmed.ncbi.nlm.nih.gov/40659086/},
}

@article{pmid40762111,
  title = {Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice.},
  author = {Cao F, Zhang P, Zheng Z, Wang P, Wang Y et al.},
  journal = {Neurol Res},
  year = {2026},
  pmid = {40762111},
  doi = {doi: 10.1080/01616412.2025.2534077},
  url = {https://pubmed.ncbi.nlm.nih.gov/40762111/},
}

@article{pmid41519399,
  title = {CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis.},
  author = {Zhang Y, Wang J, Song Y, Chai J, Li L et al.},
  journal = {Biochem Pharmacol},
  year = {2026},
  pmid = {41519399},
  doi = {doi: 10.1016/j.bcp.2026.117699},
  url = {https://pubmed.ncbi.nlm.nih.gov/41519399/},
}

@article{pmid41702081,
  title = {Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice.},
  author = {Qin H, Yang L, Du J, Xu X, Chen Z et al.},
  journal = {Int Immunopharmacol},
  year = {2026},
  pmid = {41702081},
  doi = {doi: 10.1016/j.intimp.2026.116364},
  url = {https://pubmed.ncbi.nlm.nih.gov/41702081/},
}

@article{pmid41730508,
  title = {Hyperglycaemia-induced metabolic stress and epigenetic imprinting in the inflammatory pathogenesis of diabetic neuropathy.},
  author = {Razi FB, Ashraf H, Singhal S, Qamar Z, Moin S},
  journal = {Diabetes research and clinical practice},
  year = {2026},
  pmid = {41730508},
  doi = {10.1016/j.diabres.2026.113172},
  url = {https://pubmed.ncbi.nlm.nih.gov/41730508/},
}

@article{pmid41747877,
  title = {Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's disease - Mechanisms and therapeutic frontiers.},
  author = {Waghmare A, Rahangdale S, Khare K, Taksande B, Umekar M, Mangrulkar S},
  journal = {Molecular and cellular neurosciences},
  year = {2026},
  pmid = {41747877},
  doi = {10.1016/j.mcn.2026.104075},
  url = {https://pubmed.ncbi.nlm.nih.gov/41747877/},
}

@article{pmid41778859,
  title = {The spleen-brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation.},
  author = {Yan J, Zhang J, Ye X, Wang H, Li H, Li W, Wu H, Zhao W},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2026},
  pmid = {41778859},
  doi = {10.1002/alz.71243},
  url = {https://pubmed.ncbi.nlm.nih.gov/41778859/},
}

@article{pmid41865324,
  title = {Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1/TLR4/NF-κB modulation in a rat model of huntington's disease.},
  author = {Mustafa AM, Mudhafar M, Elgindy AM, Esmail MM, Atwa AM, Shaheen AM, Radwan AF, Elfar N, Mohamed RYA, Gamil NM},
  journal = {Archives of pharmacal research},
  year = {2026},
  pmid = {41865324},
  doi = {10.1007/s12272-026-01604-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/41865324/},
}

@article{pmid41870813,
  title = {Role of Pentacyclic Triterpenes in the Management of Neurological Disorders: An Insight into Molecular Mechanisms and Therapeutic Approaches.},
  author = {Upadhayay S},
  journal = {Molecular neurobiology},
  year = {2026},
  pmid = {41870813},
  doi = {10.1007/s12035-026-05772-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/41870813/},
}

@article{pmid41877549,
  title = {Nanopiezoelectric 3D-Bioprinted Neural Organoid Models Epileptic Neuron-Microglia Circuit in Neurodegeneration.},
  author = {Chu J, Hu K, Lee WF, Xu SJ, Sun Z, Xu Y, Ning X, Yung KLK},
  journal = {Nano letters},
  year = {2026},
  pmid = {41877549},
  doi = {10.1021/acs.nanolett.5c06156},
  url = {https://pubmed.ncbi.nlm.nih.gov/41877549/},
}

@article{pmid41880086,
  title = {The Neuroameliorative Effects of Enzymatically Modified Isoquercitrin and Sodium R-lipoate on the Rotenone rat Model of Parkinson's Disease.},
  author = {Hassouna I, Hassanein OH, El-Elaimy IA, Ibrahim HM},
  journal = {Neurochemical research},
  year = {2026},
  pmid = {41880086},
  doi = {10.1007/s11064-026-04715-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41880086/},
}

@article{pmid41920384,
  title = {Curcumin and Glycyrrhiza glabra Synergistically Attenuate Alzheimer's Pathology via TLR4/NF-κB-Mediated Anti-inflammatory and Redox Modulation in a D-Gal/Sodium Nitrite-Induced Mouse Model.},
  author = {Liu S, Yan J, Dong J},
  journal = {Neurochemical research},
  year = {2026},
  pmid = {41920384},
  doi = {10.1007/s11064-026-04746-2},
  url = {https://pubmed.ncbi.nlm.nih.gov/41920384/},
}

@article{pmid41923296,
  title = {Colonic Barrier Dysfunction and Inflammation Induced by Nano-/Micro-Plastics Fibers in Mice via the FAK/NF-κB/iNOS and TLR4/NF-κB/iNOS Pathways.},
  author = {Li Y, Bao S, Huang P, Wang J, Li H, Liu Y, Wang K, Du J, Yan L, Pan G, Sun W},
  journal = {Journal of applied toxicology : JAT},
  year = {2026},
  pmid = {41923296},
  doi = {10.1002/jat.70196},
  url = {https://pubmed.ncbi.nlm.nih.gov/41923296/},
}

@article{pmid41926238,
  title = {2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota Modulation and Involvement of the LPS/TLR4 Signaling.},
  author = {Chen J, Liang S, Liu D, Yang S, Yan Q et al.},
  journal = {J Agric Food Chem},
  year = {2026},
  pmid = {41926238},
  doi = {doi: 10.1021/acs.jafc.5c12123},
  url = {https://pubmed.ncbi.nlm.nih.gov/41926238/},
}

@article{pmid41926324,
  title = {Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peritoneal metastases.},
  author = {Yan H, Chia D, Ernst S, Demuytere J, Cosyns S et al.},
  journal = {Expert Opin Drug Deliv},
  year = {2026},
  pmid = {41926324},
  doi = {doi: 10.1080/17425247.2026.2655874},
  url = {https://pubmed.ncbi.nlm.nih.gov/41926324/},
}

@article{pmid41927877,
  title = {Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses microglial inflammation in Alzheimer's disease models.},
  author = {Miao J, Wang J, Zhou W, Guo J},
  journal = {Sci Rep},
  year = {2026},
  pmid = {41927877},
  doi = {doi: 10.1038/s41598-026-46671-y},
  url = {https://pubmed.ncbi.nlm.nih.gov/41927877/},
}

@article{pmid41930627,
  title = {Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promote synovial activation and NET-mediated bone loss in Rheumatoid Arthritis.},
  author = {Nakabo S, Hanata N, Patino-Martinez E, Holewinski R, Barrera-Vargas A et al.},
  journal = {Arthritis Rheumatol},
  year = {2026},
  pmid = {41930627},
  doi = {doi: 10.1002/art.70158},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930627/},
}

@article{pmid41931545,
  title = {In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV-2 using immunoinformatics.},
  author = {Zheng N, Xu Y},
  journal = {PLoS Negl Trop Dis},
  year = {2026},
  pmid = {41931545},
  doi = {doi: 10.1371/journal.pntd.0013517},
  url = {https://pubmed.ncbi.nlm.nih.gov/41931545/},
}

@article{pmid41931597,
  title = {Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF.},
  author = {Ma B, Lyu W, Rizk J, Han X, Kjær M et al.},
  journal = {Sci Immunol},
  year = {2026},
  pmid = {41931597},
  doi = {doi: 10.1126/sciimmunol.aeb6484},
  url = {https://pubmed.ncbi.nlm.nih.gov/41931597/},
}

@article{pmid40405515,
  title = {Lectins and neurodegeneration: A glycobiologist's perspective.},
  author = {["Olejnik B", "Ferens-Sieczkowska M"]},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year = {2025},
  pmid = {40405515},
  doi = {10.17219/acem/204107},
}

@article{pmid40651297,
  title = {Lycopene ameliorates Di-(2-ethylhexyl) phthalate-induced neurotoxicity in mice via the gut-brain axis.},
  author = {Chen LJ, Liu Y, Liu JL, Chen ZJ, Zhao W, Li JH, Hsu C, Chen L, Zeng JH, Li XW, Yang JZ, Li JH, Xie XL, Tao SH, Wang Q},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year = {2025},
  pmid = {40651297},
  doi = {10.1016/j.phymed.2025.157057},
  url = {https://pubmed.ncbi.nlm.nih.gov/40651297/},
}

@article{pmid38342016,
  title = {Neuroprotection of rhubarb extract against cerebral ischaemia-reperfusion injury via the gut-brain axis pathway.},
  author = {Mao M, Cao X, Liang Y, Li Q, Chen S, Zhou L, Zhang Y, Guo Y},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year = {2024},
  pmid = {38342016},
  doi = {10.1016/j.phymed.2023.155254},
  url = {https://pubmed.ncbi.nlm.nih.gov/38342016/},
}

@article{pmid38552431,
  title = {Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and microglial activation in an AD model.},
  author = {Wang W, Wang Y, Wang F, Xie G, Liu S, Li Z, Wang P, Liu J, Lin L},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year = {2024},
  pmid = {38552431},
  doi = {10.1016/j.phymed.2024.155518},
  url = {https://pubmed.ncbi.nlm.nih.gov/38552431/},
}

@article{pmid38552431,
  title = {Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and microglial activation in an AD model.},
  author = {Wang W, Wang Y, Wang F, Xie G, Liu S, Li Z, Wang P, Liu J, Lin L},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year = {2024},
  pmid = {38552431},
}

@article{pmid39457054,
  title = {Novelties on Neuroinflammation in Alzheimer's Disease-Focus on Gut and Oral Microbiota Involvement.},
  author = {Popescu C, Munteanu C, Anghelescu A, Ciobanu V, Spînu A, Andone I, Mandu M, Bistriceanu R, Băilă M, Postoiu RL, Vlădulescu-Trandafir AI, Giuvara S, Malaelea AD, Onose G},
  journal = {International journal of molecular sciences},
  year = {2024},
  pmid = {39457054},
  doi = {10.3390/ijms252011272},
  url = {https://pubmed.ncbi.nlm.nih.gov/39457054/},
}

@article{pmid37866106,
  title = {The role of the microbiota in glaucoma.},
  author = {Huang L, Hong Y, Fu X, Tan H, Chen Y, Wang Y, Chen D},
  journal = {Molecular aspects of medicine},
  year = {2023},
  pmid = {37866106},
  doi = {10.1016/j.mam.2023.101221},
  url = {https://pubmed.ncbi.nlm.nih.gov/37866106/},
}

@article{pmid37866106,
  title = {The role of the microbiota in glaucoma.},
  author = {Huang L, Hong Y, Fu X, Tan H, Chen Y, Wang Y, Chen D},
  journal = {Molecular aspects of medicine},
  year = {2023},
  pmid = {37866106},
}

@article{pmid35642214,
  title = {Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.},
  author = {Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H},
  journal = {J Inflamm Res},
  year = {2022},
  pmid = {35642214},
  doi = {10.2147/JIR.S350109},
  url = {https://pubmed.ncbi.nlm.nih.gov/35642214},
}

@article{pmid33057840,
  title = {TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.},
  author = {["Ciesielska A", "Matyjek M", "Kwiatkowska K"]},
  journal = {Cellular and molecular life sciences : CMLS},
  year = {2021},
  pmid = {33057840},
  doi = {10.1007/s00018-020-03656-y},
}

@article{pmid33057840,
  title = {TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.},
  author = {["Ciesielska A", "Matyjek M", "Kwiatkowska K"]},
  journal = {Cellular and molecular life sciences : CMLS},
  year = {2021},
  pmid = {33057840},
}

@article{pmid33547425,
  title = {Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy.},
  author = {Lieberwirth JK, Joset P, Heinze A, Hentschel J, Stein A, Iannaccone A, Steindl K, Kuechler A, Abou Jamra R},
  journal = {European journal of human genetics : EJHG},
  year = {2021},
  pmid = {33547425},
  doi = {10.1038/s41431-020-00803-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/33547425/},
}

@article{pmid31515460,
  title = {Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model.},
  author = {Juthani R, Madajewski B, Yoo B, Zhang L, Chen PM, Chen F, Turker MZ, Ma K, Overholtzer M, Longo VA, Carlin S, Aragon-Sanabria V, Huse J, Gonen M, Zanzonico P, Rudin CM, Wiesner U, Bradbury MS, Brennan CW},
  journal = {Clinical cancer research : an official journal of the American Association for Cancer Research},
  year = {2020},
  pmid = {31515460},
  doi = {10.1158/1078-0432.CCR-19-1834},
  url = {https://pubmed.ncbi.nlm.nih.gov/31515460/},
}

@article{pmid31784264,
  title = {Modeling transport of microplastics in enclosed coastal waters: A case study in the Fethiye Inner Bay.},
  author = {Genc AN, Vural N, Balas L},
  journal = {Marine pollution bulletin},
  year = {2020},
  pmid = {31784264},
  doi = {10.1016/j.marpolbul.2019.110747},
  url = {https://pubmed.ncbi.nlm.nih.gov/31784264/},
}

@article{pmid32102174,
  title = {Environmental Regulation, Technological Innovation, and Export Competitiveness: An Empirical Study Based on China's Manufacturing Industry.},
  author = {Liu J, Xie J},
  journal = {International journal of environmental research and public health},
  year = {2020},
  pmid = {32102174},
  doi = {10.3390/ijerph17041427},
  url = {https://pubmed.ncbi.nlm.nih.gov/32102174/},
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@article{pmid32127544,
  title = {Four European Salmonella Typhimurium datasets collected to develop WGS-based source attribution methods.},
  author = {Munck N, Leekitcharoenphon P, Litrup E, Kaas R, Meinen A, Guillier L, Tang Y, Malorny B, Palma F, Borowiak M, Gourmelon M, Simon S, Banerji S, Petrovska L, Dallman TJ, Hald T},
  journal = {Scientific data},
  year = {2020},
  pmid = {32127544},
  doi = {10.1038/s41597-020-0417-7},
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}

@article{pmid32170061,
  title = {Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.},
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  journal = {Nat Commun},
  year = {2020},
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  doi = {10.1038/s41467-020-15119-w},
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}

@article{pmid33442582,
  title = {Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables.},
  author = {Karas M, Marinsek N, Goldhahn J, Foschini L, Ramirez E, Clay I},
  journal = {Digital biomarkers},
  year = {2020},
  pmid = {33442582},
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@article{pmid28420697,
  title = {Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabetes Care 2016;39:455-464.},
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  journal = {Diabetes care},
  year = {2017},
  pmid = {28420697},
  doi = {10.2337/dc17-er06a},
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@article{pmid29056339,
  title = {Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance.},
  author = {Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B},
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@article{pmid26798853,
  title = {Ciliary phosphoinositides regulate Hedgehog signalling.},
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  journal = {Nature reviews. Molecular cell biology},
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@article{pmid23147713,
  title = {Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.},
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@article{pmid23688928,
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@article{pmid18403674,
  title = {Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.},
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