% Bibliography for hypothesis h-c463d225
% Title: R-Loop Resolution Enhancement Therapy
% Generated: 2026-04-28T13:52:24Z

@article{pmid41137727,
  title = {Deciphering ALS-linked genetic variants in indian patients using targeted and exome sequencing approaches.},
  author = {["Reza S", "Handique J", "Sharma P", "Mathew S", "Bari S", "Tyagi N", "Sharma C", "Panda S", "Chowdhury D", "Laskar S"]},
  journal = {Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year = {2026},
  pmid = {41137727},
  doi = {10.1080/21678421.2025.2574681},
}

@article{pmid41518615,
  title = {N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to control HPV replication.},
  author = {["Templeton C", "Laimins L"]},
  journal = {Cell reports},
  year = {2026},
  pmid = {41518615},
  doi = {10.1016/j.celrep.2025.116828},
}

@article{pmid41533569,
  title = {The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-replication conflicts.},
  author = {Wu T, Li Y, Zhao Y, Bournique E, Ortega P, Nie M, Wang Y, Wang H, Buisson R, Hickson ID, Boddy MN, Wu X},
  journal = {Nucleic acids research},
  year = {2026},
  pmid = {41533569},
  doi = {10.1093/nar/gkaf1537},
  url = {https://pubmed.ncbi.nlm.nih.gov/41533569/},
}

@article{pmid41606223,
  title = {Molecular characterization of recessively inherited ataxic and neuropathic disorders in consanguineous Pakistani families.},
  author = {["Aslam F", "Wajid M", "Butt A", "Wohler E", "Seo G", "Ji W", "Lakhani S", "Sobreira N", "Naz S"]},
  journal = {Scientific reports},
  year = {2026},
  pmid = {41606223},
  doi = {10.1038/s41598-026-37808-0},
}

@article{pmid41621017,
  title = {Genetic commonalities between rare subtypes of ALS and CMT: insights into molecular mechanisms of neurodegeneration.},
  author = {Aynaashe A, Kursula P},
  journal = {Amino acids},
  year = {2026},
  pmid = {41621017},
  doi = {10.1007/s00726-026-03500-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/41621017/},
}

@article{pmid41621017,
  title = {Genetic commonalities between rare subtypes of ALS and CMT: insights into molecular mechanisms of neurodegeneration.},
  author = {Aynaashe A, Kursula P},
  journal = {Amino Acids},
  year = {2026},
  pmid = {41621017},
  doi = {doi: 10.1007/s00726-026-03500-w},
  url = {https://pubmed.ncbi.nlm.nih.gov/41621017/},
}

@article{pmid41917467,
  title = {Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.},
  author = {Dutta A, Ji JH, Syed S, Fang Q, Mukhopadhyay P, Wang H, Loranc E, Medina D, Abdulsahib S, Zhou S, Tovar M, Wang J, Benoit JM, Liang F, Tomimatsu N, Nyalwidhe JO, Dray E, Verway-Cohen A, McDonald DT, de la Peña Avalos B, Li W, Herrero AO, Fitzgerald O, Taylor AB, Kwon Y, Semmes OJ, Tsai MS, Rao M, Hromas R, Burma S},
  journal = {Nature structural & molecular biology},
  year = {2026},
  pmid = {41917467},
  doi = {10.1038/s41594-026-01778-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41917467/},
}

@article{pmid40200577,
  title = {Allele-specific silencing of a dominant SETX mutation in familial amyotrophic lateral sclerosis type 4.},
  author = {Winkelsas A, Apfel A, Johnson B, Harmison G, Perez KD, Li D, Cheung VG, Grunseich C},
  journal = {HGG Adv},
  year = {2025},
  pmid = {40200577},
  doi = {10.1016/j.xhgg.2025.100435},
  url = {https://pubmed.ncbi.nlm.nih.gov/40200577},
}

@article{pmid40338003,
  title = {Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinical diversity.},
  author = {["Chen X", "Chen X", "Lin X", "Zhou W", "Hu H", "Jiang H"]},
  journal = {Somatosensory & motor research},
  year = {2025},
  pmid = {40338003},
  doi = {10.1080/08990220.2025.2500940},
}

@article{pmid40475435,
  title = {Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells.},
  author = {["Wu T", "Li Y", "Shi L", "Wu X"]},
  journal = {bioRxiv : the preprint server for biology},
  year = {2025},
  pmid = {40475435},
  doi = {10.1101/2024.06.29.601361},
}

@article{pmid40830689,
  title = {Ataxia and oculomotor apraxia caused by a large-scale deletion in the senataxin gene.},
  author = {["Rusecka J", "Kierdaszuk B", "St\u0119pniak I", "Rydzanicz M", "Stawi\u0144ski P", "Gambin T", "Loska D", "Kacprzak M", "Kaliszewska M", "Piekutowska-Abramczuk D"]},
  journal = {Journal of applied genetics},
  year = {2025},
  pmid = {40830689},
  doi = {10.1007/s13353-025-01001-2},
}

@article{pmid41037402,
  title = {Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells.},
  author = {Wu T, Li Y, Zhao Y, Shah SB, Shi LZ, Wu X},
  journal = {Cell reports},
  year = {2025},
  pmid = {41037402},
  doi = {10.1016/j.celrep.2025.116386},
  url = {https://pubmed.ncbi.nlm.nih.gov/41037402/},
}

@article{pmid41196070,
  title = {Unraveling the genetic landscape of ALS in Greece: identification of known and novel causative variants in a 353-patient cohort.},
  author = {["Kartanou C", "Kontogeorgiou Z", "Loupis T", "Vrachnos D", "Ragazos N", "Spyropoulou I", "Petraki M", "Koniari C", "Aristeidou S", "Koropouli E"]},
  journal = {Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year = {2025},
  pmid = {41196070},
  doi = {10.1080/21678421.2025.2582828},
}

@article{pmid41232527,
  title = {A role for human senataxin in contending with pausing and backtracking during transcript elongation.},
  author = {Han Z, Fu S, Johansen JV, Lopez Martinez D, Lou J, Boissière T, He D, Blears D, Olthof AM, Dirac-Svejstrup AB, Svejstrup JQ},
  journal = {Molecular cell},
  year = {2025},
  pmid = {41232527},
  doi = {10.1016/j.molcel.2025.10.019},
  url = {https://pubmed.ncbi.nlm.nih.gov/41232527/},
}

@article{pmid41305523,
  title = {ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics.},
  author = {Moffitt R, Brooks S, Androphy EJ, DeSmet M},
  journal = {Viruses},
  year = {2025},
  pmid = {41305523},
  doi = {10.3390/v17111502},
  url = {https://pubmed.ncbi.nlm.nih.gov/41305523/},
}

@article{pmid37558082,
  title = {Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration.},
  author = {["Giannini M", "Porrua O"]},
  journal = {Biochimie},
  year = {2024},
  pmid = {37558082},
  doi = {10.1016/j.biochi.2023.08.001},
}

@article{pmid39070547,
  title = {Role of senataxin in R-loop-mediated neurodegeneration.},
  author = {Kannan A, Gangadharan Leela S, Branzei D, Gangwani L},
  journal = {Brain communications},
  year = {2024},
  pmid = {39070547},
  doi = {10.1093/braincomms/fcae239},
  url = {https://pubmed.ncbi.nlm.nih.gov/39070547/},
}

@article{pmid36544021,
  title = {R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response.},
  author = {Crossley MP, Song C, Bocek MJ, Choi JH, Kousouros JN, Sathirachinda A, Lin C, Brickner JR, Bai G, Lans H, Vermeulen W, Abu-Remaileh M, Cimprich KA},
  journal = {Nature},
  year = {2023},
  pmid = {36544021},
  doi = {10.1038/s41586-022-05545-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/36544021/},
}

@article{pmid37778731,
  title = {Helicases in R-loop Formation and Resolution.},
  author = {Yang S, Winstone L, Mondal S, Wu Y},
  journal = {The Journal of biological chemistry},
  year = {2023},
  pmid = {37778731},
  doi = {10.1016/j.jbc.2023.105307},
  url = {https://pubmed.ncbi.nlm.nih.gov/37778731/},
}

@article{pmid35732742,
  title = {Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.},
  author = {["Campisi L", "Chizari S", "Ho J", "Gromova A", "Arnold F", "Mosca L", "Mei X", "Fstkchyan Y", "Torre D", "Beharry C"]},
  journal = {Nature},
  year = {2022},
  pmid = {35732742},
  doi = {10.1038/s41586-022-04844-5},
}

@article{pmid32686621,
  title = {SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.},
  author = {Richard P, Feng S, Tsai YL, Li W, Rinchetti P, Muhith U, Irizarry-Cole J, Stolz K, Sanz LA, Hartono S},
  journal = {Autophagy},
  year = {2021},
  pmid = {32686621},
  doi = {10.1080/15548627.2020.1796292},
  url = {https://pubmed.ncbi.nlm.nih.gov/32686621},
}

@article{pmid34232287,
  title = {Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging.},
  author = {Crossley MP, Brickner JR, Song C, Zar SMT, Maw SS, Chédin F, Tsai MS, Cimprich KA},
  journal = {The Journal of cell biology},
  year = {2021},
  pmid = {34232287},
  doi = {10.1083/jcb.202101092},
  url = {https://pubmed.ncbi.nlm.nih.gov/34232287/},
}

@article{pmid32669707,
  title = {Nucleolar RNA polymerase II drives ribosome biogenesis.},
  author = {Abraham KJ, Khosraviani N, Chan JNY, Gorthi A, Samman A, Zhao DY, Wang M, Bokros M, Vidya E, Ostrowski LA, Oshidari R, Pietrobon V, Patel PS, Algouneh A, Singhania R, Liu Y, Yerlici VT, De Carvalho DD, Ohh M, Dickson BC, Hakem R, Greenblatt JF, Lee S, Bishop AJR, Mekhail K},
  journal = {Nature},
  year = {2020},
  pmid = {32669707},
  doi = {10.1038/s41586-020-2497-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/32669707/},
}

@article{pmid30047099,
  title = {R-Loops in Motor Neuron Diseases.},
  author = {Perego MGL, Taiana M, Bresolin N, Comi GP, Corti S},
  journal = {Molecular neurobiology},
  year = {2019},
  pmid = {30047099},
  doi = {10.1007/s12035-018-1246-y},
  url = {https://pubmed.ncbi.nlm.nih.gov/30047099/},
}

@article{pmid31533039,
  title = {Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.},
  author = {Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G},
  journal = {Cell Rep},
  year = {2019},
  pmid = {31533039},
  doi = {10.1016/j.celrep.2019.08.041},
  url = {https://pubmed.ncbi.nlm.nih.gov/31533039},
}

@article{pmid27771483,
  title = {Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration.},
  author = {Groh M, Albulescu LO, Cristini A, Gromak N},
  journal = {Journal of molecular biology},
  year = {2017},
  pmid = {27771483},
  doi = {10.1016/j.jmb.2016.10.021},
  url = {https://pubmed.ncbi.nlm.nih.gov/27771483/},
}