% Bibliography for hypothesis h-a20e0cbb
% Title: Targeted APOE4-to-APOE3 Base Editing Therapy
% Generated: 2026-04-28T14:43:48Z

@article{pmid40145985,
  title = {Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders.},
  author = {Lozupone M, Leccisotti I, Mollica A, Berardino G, Moretti MC, Altamura M, Bellomo A, Daniele A, Dibello V, Solfrizzi V, Resta E, Panza F},
  journal = {Neural regeneration research},
  year = {2026},
  pmid = {40145985},
  doi = {10.4103/NRR.NRR-D-24-01274},
  url = {https://pubmed.ncbi.nlm.nih.gov/40145985/},
}

@article{pmid40562635,
  title = {Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.},
  author = {Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.},
  journal = {Br J Anaesth},
  year = {2026},
  pmid = {40562635},
  doi = {doi: 10.1016/j.bja.2025.05.014},
  url = {https://pubmed.ncbi.nlm.nih.gov/40562635/},
}

@article{pmid40615639,
  title = {Increased genetic protection against Alzheimer's disease in centenarians.},
  author = {Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.},
  journal = {Geroscience},
  year = {2026},
  pmid = {40615639},
  doi = {doi: 10.1007/s11357-025-01774-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/40615639/},
}

@article{pmid40864401,
  title = {Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.},
  author = {Stern A, Linial M},
  journal = {Geroscience},
  year = {2026},
  pmid = {40864401},
  doi = {doi: 10.1007/s11357-025-01828-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/40864401/},
}

@article{pmid40886963,
  title = {Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasis-Associated Atherosclerosis by Inducing Mitochondrial Dysfunction in Aortic Endothelial Cells.},
  author = {Zhu L, Du L, Wu J, Ding D, Wang J et al.},
  journal = {J Invest Dermatol},
  year = {2026},
  pmid = {40886963},
  doi = {doi: 10.1016/j.jid.2025.05.041},
  url = {https://pubmed.ncbi.nlm.nih.gov/40886963/},
}

@article{pmid41445196,
  title = {Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.},
  author = {Lin Z, Xiong J, Zhang F, Zhang H, Zhu M et al.},
  journal = {Mol Ther},
  year = {2026},
  pmid = {41445196},
  doi = {doi: 10.1016/j.ymthe.2025.12.035},
  url = {https://pubmed.ncbi.nlm.nih.gov/41445196/},
}

@article{pmid41531227,
  title = {Menopause, cognition, and Alzheimer's disease risk.},
  author = {Samudra N, Vemuri M, Weitlauf J},
  journal = {Curr Opin Obstet Gynecol},
  year = {2026},
  pmid = {41531227},
  doi = {doi: 10.1097/GCO.0000000000001087},
  url = {https://pubmed.ncbi.nlm.nih.gov/41531227/},
}

@article{pmid41812941,
  title = {CRISPR-based correction of apolipoprotein E4 in Alzheimer's disease: Therapeutic strategies and macromolecular delivery innovations.},
  author = {["Wang M", "Niu D", "Zhang Q", "Tang Y", "Zhao Y", "Chen F"]},
  journal = {International journal of biological macromolecules},
  year = {2026},
  pmid = {41812941},
  doi = {10.1016/j.ijbiomac.2026.151352},
}

@article{pmid41828651,
  title = {Brain Single-Cell Transcriptional Responses to Bexarotene-Activated RXR in an Alzheimer's Disease Model.},
  author = {Saibro-Girardi C, Lu Y, Fitz NF, Gelain DP, Lefterov I, Koldamova R},
  journal = {International journal of molecular sciences},
  year = {2026},
  pmid = {41828651},
  doi = {10.3390/ijms27052435},
  url = {https://pubmed.ncbi.nlm.nih.gov/41828651/},
}

@article{pmid41830286,
  title = {Betulinic Acid Attenuates Vascular Smooth Muscle Cell Senescence and Aortic Vascular Aging via PPAR-α/CPT1A-Mediated Fatty Acid Oxidation.},
  author = {Lu T, Wang L, Chen S, Wang T, Sun N, Qin C, Yan J, Ma Y, Yin H, Shen X, Cao F},
  journal = {Rejuvenation research},
  year = {2026},
  pmid = {41830286},
  doi = {10.1177/15491684261429991},
  url = {https://pubmed.ncbi.nlm.nih.gov/41830286/},
}

@article{pmid41867029,
  title = {Can we refute a role for infections in Alzheimer's disease pathogenesis?},
  author = {Chatila ZK, Duggan MR, Silberberg E, Fernandez J, Auber LA, Bradshaw EM, Schultek NM},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2026},
  pmid = {41867029},
  doi = {10.1002/alz.71288},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867029/},
}

@article{pmid41889903,
  title = {Long-Read Transcriptome Sequencing and Functional Validation Reveals Novel and Oncogenic Gene Fusions in Fusion Panel-Negative Gliomas.},
  author = {Rybacki K, Cha ENY, Deutsch HM, Gaudet E, Ahsan MU, Xu F, Chan J, Li M, Song Y, Wang K},
  journal = {bioRxiv : the preprint server for biology},
  year = {2026},
  pmid = {41889903},
  doi = {10.64898/2026.03.13.711117},
  url = {https://pubmed.ncbi.nlm.nih.gov/41889903/},
}

@article{pmid41890452,
  title = {Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzheimer's Disease Neurodegeneration: A Systematic Review.},
  author = {Arriaga P, Vianna K, Montez C, Panariello B, Tran S, Rodrigues D, Porto Barboza E},
  journal = {Cureus},
  year = {2026},
  pmid = {41890452},
  doi = {10.7759/cureus.104127},
  url = {https://pubmed.ncbi.nlm.nih.gov/41890452/},
}

@article{pmid41897058,
  title = {Exploratory Associations of Targeted Genetic Variants with Cephalometric Airway Parameters in Children with Skeletal Class II Sleep-Disordered Breathing Symptoms.},
  author = {Karaca Kurt N, Algul H, Ceylaner S, Ceylaner G, Altug AT, Toygar Memikoglu TU},
  journal = {Children (Basel, Switzerland)},
  year = {2026},
  pmid = {41897058},
  doi = {10.3390/children13030345},
  url = {https://pubmed.ncbi.nlm.nih.gov/41897058/},
}

@article{pmid41899281,
  title = {Alzheimer's Disease: From Pathogenesis to Emerging Therapeutic Targets.},
  author = {Takahashi T, Muguruma K},
  journal = {Journal of clinical medicine},
  year = {2026},
  pmid = {41899281},
  doi = {10.3390/jcm15062357},
  url = {https://pubmed.ncbi.nlm.nih.gov/41899281/},
}

@article{pmid41906524,
  title = {A mechanistic study of mitochondria-targeted PCSK9 liposomes attenuate oxidative damage in carotid artery plaques.},
  author = {Zhang L, Chen G, Bai Y, Li Q},
  journal = {Journal of liposome research},
  year = {2026},
  pmid = {41906524},
  doi = {10.1080/08982104.2026.2651190},
  url = {https://pubmed.ncbi.nlm.nih.gov/41906524/},
}

@article{pmid40653819,
  title = {Lipid nanoparticle formulation for gene editing and RNA-based therapies for glioblastoma.},
  author = {["Zhang Y", "Rabinovsky R", "Deforzh E", "Kobayashi A", "Kuzkina A", "Varghese J", "Rai D", "Korecka J", "Khurana V", "Murugaiyan G"]},
  journal = {Neuro-oncology},
  year = {2025},
  pmid = {40653819},
  doi = {10.1093/neuonc/noaf162},
}

@article{pmid38753766,
  title = {An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.},
  author = {Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A},
  journal = {Science},
  year = {2024},
  pmid = {38753766},
  doi = {10.1126/science.adm8386},
  url = {https://pubmed.ncbi.nlm.nih.gov/38753766},
}

@article{pmid38870781,
  title = {Activation of Nrf2 inhibits atherosclerosis in ApoE-/- mice through suppressing endothelial cell inflammation and lipid peroxidation.},
  author = {He L, Chen Q, Wang L, Pu Y, Huang J, Cheng CK, Luo JY, Kang L, Lin X, Xiang L, Fang L, He B, Xia Y, Lui KO, Pan Y, Liu J, Zhang CL, Huang Y},
  journal = {Redox biology},
  year = {2024},
  pmid = {38870781},
  doi = {10.1016/j.redox.2024.103229},
  url = {https://pubmed.ncbi.nlm.nih.gov/38870781/},
}

@article{pmid38997283,
  title = {Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade.},
  author = {["von Roemeling C", "Patel J", "Carpenter S", "Yegorov O", "Yang C", "Bhatia A", "Doonan B", "Russell R", "Trivedi V", "Klippel K"]},
  journal = {Nature communications},
  year = {2024},
  pmid = {38997283},
  doi = {10.1038/s41467-024-49989-1},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Translational neurodegeneration},
  year = {2024},
  pmid = {39232848},
  doi = {10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Transl Neurodegener},
  year = {2024},
  pmid = {39232848},
  doi = {doi: 10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid39529170,
  title = {Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells.},
  author = {["Wu L", "Jiang S", "Shi M", "Yuan T", "Li Y", "Huang P", "Li Y", "Zuo E", "Zhou C", "Sun Y"]},
  journal = {Genome biology},
  year = {2024},
  pmid = {39529170},
  doi = {10.1186/s13059-024-03434-0},
}

@article{pmid35298921,
  title = {ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias.},
  author = {Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G},
  journal = {Neuron},
  year = {2022},
  pmid = {35298921},
  doi = {10.1016/j.neuron.2022.03.004},
  url = {https://pubmed.ncbi.nlm.nih.gov/35298921/},
}

@article{pmid35639372,
  title = {Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.},
  author = {["Le Guen Y", "Belloy M", "Grenier-Boley B", "de Rojas I", "Castillo-Morales A", "Jansen I", "Nicolas A", "Bellenguez C", "Dalmasso C", "K\u00fc\u00e7\u00fckali F"]},
  journal = {JAMA neurology},
  year = {2022},
  pmid = {35639372},
  doi = {10.1001/jamaneurol.2022.1166},
}

@article{pmid36281672,
  title = {Delayed Decline of Cognitive Function by Antihypertensive Agents: A Cohort Study Linked with Genotype Data.},
  author = {["Sternberg Z", "Podolsky R", "Yu J", "Tian M", "Hojnacki D", "Schaller B"]},
  journal = {The journal of prevention of Alzheimer's disease},
  year = {2022},
  pmid = {36281672},
  doi = {10.14283/jpad.2022.73},
}

@article{pmid36334354,
  title = {In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications.},
  author = {["Huang K", "Zapata D", "Tang Y", "Teng Y", "Li Y"]},
  journal = {Biomaterials},
  year = {2022},
  pmid = {36334354},
  doi = {10.1016/j.biomaterials.2022.121876},
}

@article{pmid36348357,
  title = {ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.},
  author = {Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC},
  journal = {Mol Neurodegener},
  year = {2022},
  pmid = {36348357},
  doi = {10.1186/s13024-022-00574-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/36348357},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {doi: 10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485/},
}

@article{pmid31937940,
  title = {Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses.},
  author = {["Levy J", "Yeh W", "Pendse N", "Davis J", "Hennessey E", "Butcher R", "Koblan L", "Comander J", "Liu Q", "Liu D"]},
  journal = {Nature biomedical engineering},
  year = {2020},
  pmid = {31937940},
  doi = {10.1038/s41551-019-0501-5},
}

@article{pmid31367008,
  title = {Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.},
  author = {Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G},
  journal = {Nat Rev Neurol},
  year = {2019},
  pmid = {31367008},
  doi = {10.1038/s41582-019-0228-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/31367008},
}

@article{pmid31367008,
  title = {Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.},
  author = {Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G},
  journal = {Nat Rev Neurol},
  year = {2019},
  pmid = {31367008},
  doi = {doi: 10.1038/s41582-019-0228-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/31367008/},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {doi: 10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456/},
}

@article{pmid31725765,
  title = {Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.},
  author = {["Huang Q", "Chan K", "Tobey I", "Chan Y", "Poterba T", "Boutros C", "Balazs A", "Daneman R", "Bloom J", "Seed C"]},
  journal = {PloS one},
  year = {2019},
  pmid = {31725765},
  doi = {10.1371/journal.pone.0225206},
}

@article{pmid28930663,
  title = {The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.},
  author = {Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z},
  journal = {Immunity},
  year = {2017},
  pmid = {28930663},
  doi = {10.1016/j.immuni.2017.08.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/28930663},
}

@article{pmid24293121,
  title = {Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.},
  author = {["Ungar L", "Altmann A", "Greicius M"]},
  journal = {Brain imaging and behavior},
  year = {2014},
  pmid = {24293121},
  doi = {10.1007/s11682-013-9272-x},
}

@article{pmid23296339,
  title = {Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.},
  author = {Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G},
  journal = {Nature reviews. Neurology},
  year = {2013},
  pmid = {23296339},
  doi = {10.1038/nrneurol.2012.263},
  url = {https://pubmed.ncbi.nlm.nih.gov/23296339/},
}

@article{pmid23296339,
  title = {Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.},
  author = {Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G},
  journal = {Nat Rev Neurol},
  year = {2013},
  pmid = {23296339},
  doi = {doi: 10.1038/nrneurol.2012.263},
  url = {https://pubmed.ncbi.nlm.nih.gov/23296339/},
}

@article{pmid23619368,
  title = {Dietary fatty acids and lipoprotein metabolism: new insights and updates.},
  author = {["Ooi E", "Ng T", "Watts G", "Barrett P"]},
  journal = {Current opinion in lipidology},
  year = {2013},
  pmid = {23619368},
  doi = {10.1097/MOL.0b013e3283613ba2},
}

@article{pmid20461061,
  title = {Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.},
  author = {Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, Butler JS, Qin L, Racie T, Sprague A, Fava E, Zeigerer A, Hope MJ, Zerial M, Sah DW, Fitzgerald K, Tracy MA, Manoharan M, Koteliansky V, Fougerolles Ad, Maier MA},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year = {2010},
  pmid = {20461061},
  doi = {10.1038/mt.2010.85},
  url = {https://pubmed.ncbi.nlm.nih.gov/20461061/},
}