% Bibliography for hypothesis h-61196ade
% Title: TREM2-Dependent Microglial Senescence Transition
% Generated: 2026-04-27T15:27:15Z

@article{pmid41757182,
  title = {Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins.},
  author = {["Puerta R", "Garc\u00eda-Gonz\u00e1lez P", "de Rojas I", "Capdevila-Bayo M", "Oliv\u00e9 C", "Mu\u00f1oz-Morales \u00c1", "Bay\u00f3n-Buj\u00e1n P", "Valenzuela A", "Yang C", "Timsina J"]},
  journal = {medRxiv : the preprint server for health sciences},
  year = {2026},
  pmid = {41757182},
  doi = {10.64898/2026.02.12.26345733},
}

@article{pmid41770935,
  title = {Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.},
  author = {["Konstantoulea K", "Ramakers M", "Borrie S", "T'Syen D", "Moechars D", "Sliwinska M", "Pradhan B", "Albertini G", "Balig\u00e1cs N", "Tsaka G"]},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year = {2026},
  pmid = {41770935},
  doi = {10.1073/pnas.2516774123},
}

@article{pmid41772384,
  title = {Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of Huntington's disease.},
  author = {["Siew J", "Lee C", "Chen H", "Lin H", "Liu Y", "Lee Y", "Wu Y", "Chen H", "Liu F", "Lin C"]},
  journal = {Brain : a journal of neurology},
  year = {2026},
  pmid = {41772384},
  doi = {10.1093/brain/awag069},
}

@article{pmid41792456,
  title = {TREM2 in neurodegeneration and diseases.},
  author = {["Abdulkhaliq A", "Alasiri G", "Kim B", "Khan J", "Ajoolabady A", "Yousof S", "Ren J", "Tuomilehto J", "Borai A", "Alrfaei B"]},
  journal = {Molecular psychiatry},
  year = {2026},
  pmid = {41792456},
  doi = {10.1038/s41380-026-03505-7},
}

@article{pmid41833042,
  title = {Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and Targeted Therapeutics.},
  author = {["Lyu G", "Li D"]},
  journal = {CNS & neurological disorders drug targets},
  year = {2026},
  pmid = {41833042},
  doi = {10.2174/0118715273435428251202075956},
}

@article{pmid41858793,
  title = {Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication.},
  author = {["Wang R", "Feng Y", "Zhou Z", "Jiang J", "Zhang R", "Zou W", "Yang H", "Lv W", "Yang S"]},
  journal = {Frontiers in aging neuroscience},
  year = {2026},
  pmid = {41858793},
  doi = {10.3389/fnagi.2026.1748418},
}

@article{pmid41881962,
  title = {Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.},
  author = {Baek S, Jang J, Yeo S, Jung HJ, Choe Y},
  journal = {Signal transduction and targeted therapy},
  year = {2026},
  pmid = {41881962},
  doi = {10.1038/s41392-026-02620-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41881962/},
}

@article{pmid41887542,
  title = {The microglial TREM2 receptor programs hippocampal development in a mouse model of childhood deprivation.},
  author = {Ahmed S, Bowers C, Munoz-Martin J, Jamwal S, Sanganahalli BG, Chen K, Giuliano L, MacDowell Kaswan ZA, Hyder F, Yang XW, Kaffman A},
  journal = {Brain, behavior, and immunity},
  year = {2026},
  pmid = {41887542},
  doi = {10.1016/j.bbi.2026.106555},
  url = {https://pubmed.ncbi.nlm.nih.gov/41887542/},
}

@article{pmid41888907,
  title = {PLCG2 signaling and genetic resilience in Alzheimer's disease.},
  author = {Tsai AP, Martin AK, Mi A, Yeh AE, Ramirez Lopez E, Wyss-Coray T},
  journal = {Molecular neurodegeneration},
  year = {2026},
  pmid = {41888907},
  doi = {10.1186/s13024-026-00935-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41888907/},
}

@article{pmid41888907,
  title = {PLCG2 signaling and genetic resilience in Alzheimer's disease.},
  author = {Tsai AP, Martin AK, Mi A, Yeh AE, Ramirez Lopez E et al.},
  journal = {Mol Neurodegener},
  year = {2026},
  pmid = {41888907},
  doi = {doi: 10.1186/s13024-026-00935-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41888907/},
}

@article{pmid41907842,
  title = {Molecular mechanism of Alzheimer's disease using integrated multi-omics.},
  author = {Alhusaini M, Mussa BM, Ilce BY, Alhaj H, Hamoudi R},
  journal = {Frontiers in aging neuroscience},
  year = {2026},
  pmid = {41907842},
  doi = {10.3389/fnagi.2026.1735696},
  url = {https://pubmed.ncbi.nlm.nih.gov/41907842/},
}

@article{pmid41926312,
  title = {Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell Therapy for Alzheimer's Disease.},
  author = {["Mehrabadi S"]},
  journal = {Current aging science},
  year = {2026},
  pmid = {41926312},
  doi = {10.2174/0118746098414335251203135400},
}

@article{pmid41930604,
  title = {TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.},
  author = {Yang HC, Deng YS, Zhang J, Zhang T, Song W et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930604},
  doi = {doi: 10.1177/13872877261437264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930604/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year = {2025},
  pmid = {38769824},
  doi = {10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {Neuroscientist},
  year = {2025},
  pmid = {38769824},
  doi = {doi: 10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid36368315,
  title = {TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.},
  author = {Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM},
  journal = {Neuron},
  year = {2023},
  pmid = {36368315},
  doi = {10.1016/j.neuron.2022.10.022},
  url = {https://pubmed.ncbi.nlm.nih.gov/36368315/},
}

@article{pmid37099634,
  title = {Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice.},
  author = {Parhizkar S, Gent G, Chen Y, Rensing N, Gratuze M, Strout G, Sviben S, Tycksen E, Zhang Q, Gilmore PE, Sprung R, Malone J, Chen W, Remolina Serrano J, Bao X, Lee C, Wang C, Landsness E, Fitzpatrick J, Wong M, Townsend R, Colonna M, Schmidt RE, Holtzman DM},
  journal = {Science translational medicine},
  year = {2023},
  pmid = {37099634},
  doi = {10.1126/scitranslmed.ade6285},
  url = {https://pubmed.ncbi.nlm.nih.gov/37099634/},
}

@article{pmid37442133,
  title = {TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.},
  author = {Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF},
  journal = {Immunity},
  year = {2023},
  pmid = {37442133},
  doi = {10.1016/j.immuni.2023.06.016},
  url = {https://pubmed.ncbi.nlm.nih.gov/37442133/},
}

@article{pmid34916658,
  title = {TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.},
  author = {Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ},
  journal = {Nature neuroscience},
  year = {2022},
  pmid = {34916658},
  doi = {10.1038/s41593-021-00975-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/34916658/},
}

@article{pmid35459866,
  title = {TREM2 signaling and function in health and disease},
  author = {Deczkowska A, Weiner A, Bhatt D, et al.},
  journal = {Immunity Reviews},
  year = {2022},
  pmid = {35459866},
  doi = {10.1016/j.immuni.2022.03.006},
  url = {https://pubmed.ncbi.nlm.nih.gov/35459866/},
}

@article{pmid35642214,
  title = {Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.},
  author = {Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H},
  journal = {J Inflamm Res},
  year = {2022},
  pmid = {35642214},
  doi = {10.2147/JIR.S350109},
  url = {https://pubmed.ncbi.nlm.nih.gov/35642214},
}

@article{pmid36306735,
  title = {TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.},
  author = {Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M},
  journal = {Cell},
  year = {2022},
  pmid = {36306735},
  doi = {10.1016/j.cell.2022.09.033},
  url = {https://pubmed.ncbi.nlm.nih.gov/36306735/},
}

@article{pmid36306735,
  title = {TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.},
  author = {Wang S, Sudan R, Peng V, Zhou Y, Du S et al.},
  journal = {Cell},
  year = {2022},
  pmid = {36306735},
  doi = {doi: 10.1016/j.cell.2022.09.033},
  url = {https://pubmed.ncbi.nlm.nih.gov/36306735/},
}

@article{pmid36327895,
  title = {Microglia states and nomenclature: A field at its crossroads.},
  author = {Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL},
  journal = {Neuron},
  year = {2022},
  pmid = {36327895},
  doi = {10.1016/j.neuron.2022.10.020},
  url = {https://pubmed.ncbi.nlm.nih.gov/36327895/},
}

@article{pmid36356585,
  title = {TREM2 deficiency eliminates TREM2+ inflammatory macrophages and improves pathological phenotypes of Alzheimer's disease mouse models reducing neuroinflammation},
  author = {Lee SH, Meilandt WJ, Xie L, et al.},
  journal = {Molecular Neurodegeneration},
  year = {2022},
  pmid = {36356585},
  doi = {10.1186/s13024-022-00576-1},
  url = {https://pubmed.ncbi.nlm.nih.gov/36356585/},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818},
}

@article{pmid33516818,
  title = {TREM2, microglia, and Alzheimer's disease.},
  author = {Qin Q, Teng Z, Liu C, Li Q, Yin Y et al.},
  journal = {Mech Ageing Dev},
  year = {2021},
  pmid = {33516818},
  doi = {doi: 10.1016/j.mad.2021.111438},
  url = {https://pubmed.ncbi.nlm.nih.gov/33516818/},
}

@article{pmid33637700,
  title = {Therapeutic benefit of selectively eliminating p21-expressing senescent cells in experimental Alzheimer's disease},
  author = {Musi N, Valentine JM, Sickber KR, et al.},
  journal = {Cell Metabolism},
  year = {2021},
  pmid = {33637700},
  doi = {10.1016/j.cmet.2021.01.020},
  url = {https://pubmed.ncbi.nlm.nih.gov/33637700/},
}

@article{pmid34043900,
  title = {Cellular senescence and neurodegeneration},
  author = {Martínez-Cué C, Rueda N},
  journal = {Frontiers in Cellular Neuroscience},
  year = {2021},
  pmid = {34043900},
  doi = {10.3389/fncel.2021.646518},
  url = {https://pubmed.ncbi.nlm.nih.gov/34043900/},
}

@article{pmid31932797,
  title = {Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.},
  author = {Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S},
  journal = {Nat Med},
  year = {2020},
  pmid = {31932797},
  doi = {10.1038/s41591-019-0695-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/31932797},
}

@article{pmid31932797,
  title = {Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.},
  author = {Zhou Y, Song WM, Andhey PS, Swain A, Levy T et al.},
  journal = {Nat Med},
  year = {2020},
  pmid = {31932797},
  doi = {doi: 10.1038/s41591-019-0695-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/31932797/},
}

@article{pmid33028628,
  title = {Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions.},
  author = {Luhur A, Mariyappa D, Klueg KM, Buddika K, Tennessen JM, Zelhof AC},
  journal = {G3 (Bethesda, Md.)},
  year = {2020},
  pmid = {33028628},
  doi = {10.1534/g3.120.401769},
  url = {https://pubmed.ncbi.nlm.nih.gov/33028628/},
}

@article{pmid33199864,
  title = {TREM2 function in Alzheimer's disease and neurodegeneration},
  author = {Gratuze M, Leyns CEG, Holtzman DM},
  journal = {Molecular Neurodegeneration},
  year = {2020},
  pmid = {33199864},
  doi = {10.1186/s13024-020-00410-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/33199864/},
}

@article{pmid31261156,
  title = {Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome.},
  author = {Presta V, Miceli F, Tocci G},
  journal = {Cardiology},
  year = {2019},
  pmid = {31261156},
  doi = {10.1159/000500321},
  url = {https://pubmed.ncbi.nlm.nih.gov/31261156/},
}

@article{pmid31591459,
  title = {Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study.},
  author = {Zheng J, Xie SH, Santoni G, Lagergren J},
  journal = {British journal of cancer},
  year = {2019},
  pmid = {31591459},
  doi = {10.1038/s41416-019-0598-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/31591459/},
}

@article{pmid32555428,
  title = {Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model},
  author = {Zhang P, Kishimoto Y, Grammatikakis I, et al.},
  journal = {Nature Neuroscience},
  year = {2019},
  pmid = {32555428},
  doi = {10.1038/s41593-019-0372-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/32555428/},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038},
}

@article{pmid28802038,
  title = {TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.},
  author = {Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A et al.},
  journal = {Cell},
  year = {2017},
  pmid = {28802038},
  doi = {doi: 10.1016/j.cell.2017.07.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/28802038/},
}

@article{pmid28930663,
  title = {The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.},
  author = {Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z},
  journal = {Immunity},
  year = {2017},
  pmid = {28930663},
  doi = {10.1016/j.immuni.2017.08.008},
  url = {https://pubmed.ncbi.nlm.nih.gov/28930663},
}

@article{pmid30154510,
  title = {sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers},
  author = {Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, et al.},
  journal = {EMBO Molecular Medicine},
  year = {2016},
  pmid = {30154510},
  doi = {10.15252/emmm.201506516},
  url = {https://pubmed.ncbi.nlm.nih.gov/30154510/},
}