% Bibliography for hypothesis h-59d95760
% Title: Epigenetic Age Acceleration Moderates the Amyloid-to-Tau Conversion Cascade — A "Clock Threshold" Model of AD Progression
% Generated: 2026-04-28T19:34:53Z

@article{pmid40044789,
  title = {Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.},
  author = {["Qi Chao", "L\u00f6vestam Sofia", "Murzin Alexey G", "Peak-Chew Sew", "Franco Catarina"]},
  journal = {Nature structural & molecular biology},
  year = {2025},
  pmid = {40044789},
  doi = {10.1038/s41594-025-01498-5},
}

@article{pmid40044789,
  title = {Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.},
  author = {["Qi Chao", "L\u00f6vestam Sofia", "Murzin Alexey G", "Peak-Chew Sew", "Franco Catarina"]},
  journal = {Nature structural & molecular biology},
  year = {2025},
  pmid = {40044789},
}

@article{pmid40346984,
  title = {Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging.},
  author = {Leskien M, Thiering E, Yu Z},
  journal = {Allergy},
  year = {2025},
  pmid = {40346984},
}

@article{pmid40618086,
  title = {Epigenetic age acceleration and allergic diseases: a bidirectional two-sample Mendelian randomization study.},
  author = {Sun J, Fan G, Hu L},
  journal = {Clin Epigenetics},
  year = {2025},
  pmid = {40618086},
}

@article{pmid38782200,
  title = {DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease.},
  author = {Zhou JX, Li LX, Zhang H},
  journal = {Kidney Int},
  year = {2024},
  pmid = {38782200},
}

@article{pmid36843263,
  title = {Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.},
  author = {Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK},
  journal = {Autophagy},
  year = {2023},
  pmid = {36843263},
  doi = {10.1080/15548627.2023.2181614},
  url = {https://pubmed.ncbi.nlm.nih.gov/36843263/},
}

@article{pmid36843263,
  title = {Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.},
  author = {Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK},
  journal = {Autophagy},
  year = {2023},
  pmid = {36843263},
}

@article{pmid37095250,
  title = {Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.},
  author = {Mummery CJ, Börjesson-Hanson A, Blackburn DJ, Vijverberg EGB, De Deyn PP, Ducharme S, Jonsson M, Schneider A, Rinne JO, Ludolph AC, Bodenschatz R, Kordasiewicz H, Swayze EE, Fitzsimmons B, Mignon L, Moore KM, Yun C, Baumann T, Li D, Norris DA, Crean R, Graham DL, Huang E, Ratti E, Bennett CF, Junge C, Lane RM},
  journal = {Nature medicine},
  year = {2023},
  pmid = {37095250},
  doi = {10.1038/s41591-023-02326-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/37095250/},
}

@article{pmid37095250,
  title = {Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.},
  author = {Mummery CJ, Börjesson-Hanson A, Blackburn DJ, Vijverberg EGB, De Deyn PP, Ducharme S, Jonsson M, Schneider A, Rinne JO, Ludolph AC, Bodenschatz R, Kordasiewicz H, Swayze EE, Fitzsimmons B, Mignon L, Moore KM, Yun C, Baumann T, Li D, Norris DA, Crean R, Graham DL, Huang E, Ratti E, Bennett CF, Junge C, Lane RM},
  journal = {Nature medicine},
  year = {2023},
  pmid = {37095250},
}

@article{pmid35063084,
  title = {Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.},
  author = {Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L},
  journal = {Cell},
  year = {2022},
  pmid = {35063084},
  doi = {10.1016/j.cell.2021.12.041},
  url = {https://pubmed.ncbi.nlm.nih.gov/35063084/},
}

@article{pmid35063084,
  title = {Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.},
  author = {Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L},
  journal = {Cell},
  year = {2022},
  pmid = {35063084},
}

@article{pmid33930583,
  title = {A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration.},
  author = {Oblak L, van der Zaag J, Higgins-Chen AT},
  journal = {Ageing Res Rev},
  year = {2021},
  pmid = {33930583},
}

@article{pmid30742061,
  title = {MAPT mutations, tauopathy, and mechanisms of neurodegeneration.},
  author = {Strang KH, Golde TE, Giasson BI},
  journal = {Laboratory investigation; a journal of technical methods and pathology},
  year = {2019},
  pmid = {30742061},
  doi = {10.1038/s41374-019-0197-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/30742061/},
}

@article{pmid30742061,
  title = {MAPT mutations, tauopathy, and mechanisms of neurodegeneration.},
  author = {Strang KH, Golde TE, Giasson BI},
  journal = {Laboratory investigation; a journal of technical methods and pathology},
  year = {2019},
  pmid = {30742061},
}

@article{pmid24138928,
  title = {DNA methylation age of human tissues and cell types.},
  author = {Horvath S},
  journal = {Genome Biol},
  year = {2013},
  pmid = {24138928},
}