% Bibliography for hypothesis h-4bb7fd8c
% Title: Nutrient-Sensing Epigenetic Circuit Reactivation
% Generated: 2026-04-28T15:36:08Z

@article{pmid41645754,
  title = {Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review).},
  author = {Li W, Wang WH, Song Y, Li XJ, Li Y et al.},
  journal = {Int J Mol Med},
  year = {2026},
  pmid = {41645754},
  doi = {pii: 84. doi: 10.3892/ijmm.2026.5755},
  url = {https://pubmed.ncbi.nlm.nih.gov/41645754/},
}

@article{pmid41692938,
  title = {Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival.},
  author = {Ungvari Z, Menyhárt O, Ocana A, Lehoczki A, Fekete M, Bianchini G, Győrffy B},
  journal = {GeroScience},
  year = {2026},
  pmid = {41692938},
  doi = {10.1007/s11357-026-02143-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/41692938/},
}

@article{pmid41714304,
  title = {Unraveling Network Pharmacology-Based Therapeutics of Anthranilate Sulfonamides via Sirtuins/FOXO3a Cascade in Alzheimer's Disease.},
  author = {Ruankham W, Prachayasittikul V, Pingaew R, Jeungprasopsuk W, Tantimongcolwat T, Prachayasittikul V, Prachayasittikul S, Phopin K},
  journal = {Journal of neurochemistry},
  year = {2026},
  pmid = {41714304},
  doi = {10.1111/jnc.70377},
  url = {https://pubmed.ncbi.nlm.nih.gov/41714304/},
}

@article{pmid41759326,
  title = {Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases.},
  author = {Shah A, Doshi G},
  journal = {Ageing research reviews},
  year = {2026},
  pmid = {41759326},
  doi = {10.1016/j.arr.2026.103072},
  url = {https://pubmed.ncbi.nlm.nih.gov/41759326/},
}

@article{pmid41830033,
  title = {Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity.},
  author = {Jalouli M, Harrath AH, Al-Zharani M, Rahman MA},
  journal = {Nutrients},
  year = {2026},
  pmid = {41830033},
  doi = {10.3390/nu18050863},
  url = {https://pubmed.ncbi.nlm.nih.gov/41830033/},
}

@article{pmid41844011,
  title = {Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzheimer's disease with brain-tissue validation.},
  author = {Wu L, Dong YT, Mu X, Luo X, Chen ZJ},
  journal = {The journal of prevention of Alzheimer's disease},
  year = {2026},
  pmid = {41844011},
  doi = {10.1016/j.tjpad.2026.100535},
  url = {https://pubmed.ncbi.nlm.nih.gov/41844011/},
}

@article{pmid41844011,
  title = {Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzheimer's disease with brain-tissue validation.},
  author = {Wu L, Dong YT, Mu X, Luo X, Chen ZJ},
  journal = {J Prev Alzheimers Dis},
  year = {2026},
  pmid = {41844011},
  doi = {doi: 10.1016/j.tjpad.2026.100535},
  url = {https://pubmed.ncbi.nlm.nih.gov/41844011/},
}

@article{pmid41863647,
  title = {Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging.},
  author = {Ramamonjiharisoa MBM, Liu S},
  journal = {Amino acids},
  year = {2026},
  pmid = {41863647},
  doi = {10.1007/s00726-026-03515-3},
  url = {https://pubmed.ncbi.nlm.nih.gov/41863647/},
}

@article{pmid41868184,
  title = {Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerative Diseases: A Comprehensive Review.},
  author = {Liu Z, Zhang H, Wan B, Yin S, Yue R},
  journal = {Drug design, development and therapy},
  year = {2026},
  pmid = {41868184},
  doi = {10.2147/DDDT.S580330},
  url = {https://pubmed.ncbi.nlm.nih.gov/41868184/},
}

@article{pmid41869013,
  title = {Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential intervention strategies.},
  author = {Chen W, Huang S, He L, Zhou X, Li R, Wang G},
  journal = {Frontiers in cell and developmental biology},
  year = {2026},
  pmid = {41869013},
  doi = {10.3389/fcell.2026.1756033},
  url = {https://pubmed.ncbi.nlm.nih.gov/41869013/},
}

@article{pmid41877258,
  title = {Uncovering the metabolic-epigenetic links between gene expression and stroke: insights from lactylation pathway MR study.},
  author = {Kan J, Hong Y, Min R, Zhang B, Wang H},
  journal = {Neurological research and practice},
  year = {2026},
  pmid = {41877258},
  doi = {10.1186/s42466-026-00478-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/41877258/},
}

@article{pmid41879438,
  title = {Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebral Ischemia via SIRT1-Driven Mitochondrial Biogenesis.},
  author = {Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S},
  journal = {Current neuropharmacology},
  year = {2026},
  pmid = {41879438},
  doi = {10.2174/011570159X417392251118050138},
  url = {https://pubmed.ncbi.nlm.nih.gov/41879438/},
}

@article{pmid41880654,
  title = {Urolithin A Reverses Intranigral Rotenone-Generated Parkinsonism by Modulating DNA Methyltransferase 1 and α-Synuclein Axis in Rats.},
  author = {Devi A, Singh SB, Srivastava S, Dandekar MP},
  journal = {ACS chemical neuroscience},
  year = {2026},
  pmid = {41880654},
  doi = {10.1021/acschemneuro.5c00362},
  url = {https://pubmed.ncbi.nlm.nih.gov/41880654/},
}

@article{pmid41894075,
  title = {Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic Insights into Nrf2, NF-κB, TrkB, SIRT1, MAPK, and JAK/STAT signalling pathways.},
  author = {Kuwar Omkar Kumar; Tejpal Sandip; Sharma Vipul; Sharma Akash; Rao Aayush; Attri Mayank; Pallavi Mamta Sachdeva},
  journal = {Molecular biology reports},
  year = {2026},
  pmid = {41894075},
  doi = {10.1007/s11033-026-11729-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/41894075/},
}

@article{pmid41898317,
  title = {All the Way: A Decade of SIRT1 in Breast Cancer.},
  author = {Pratelli G, Montalbano M, Affranchi F, Occhipinti C, Lauricella M, Carlisi D, De Blasio A},
  journal = {Biomedicines},
  year = {2026},
  pmid = {41898317},
  doi = {10.3390/biomedicines14030671},
  url = {https://pubmed.ncbi.nlm.nih.gov/41898317/},
}

@article{pmid41902653,
  title = {Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis?},
  author = {Merlo S, Lipari CLR, Patti A, Sortino MA},
  journal = {Phytotherapy research : PTR},
  year = {2026},
  pmid = {41902653},
  doi = {10.1002/ptr.70317},
  url = {https://pubmed.ncbi.nlm.nih.gov/41902653/},
}

@article{pmid41915008,
  title = {NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle stem cell differentiation.},
  author = {Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, Niu Z, Chen J, Wu Y, Li Y, Jin ZB, Li Y, Ying H},
  journal = {Journal of molecular cell biology},
  year = {2026},
  pmid = {41915008},
  doi = {10.1093/jmcb/mjag015},
  url = {https://pubmed.ncbi.nlm.nih.gov/41915008/},
}

@article{pmid39570804,
  title = {PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis.},
  author = {Zhou Z, Yin X, Sun H, Lu J, Li Y, Fan Y, Lv P, Han M, Wu J, Li S, Liu Z, Zhao H, Sun H, Fan H, Wang S, Xin T},
  journal = {Cancer research},
  year = {2025},
  pmid = {39570804},
  doi = {10.1158/0008-5472.CAN-24-1412},
  url = {https://pubmed.ncbi.nlm.nih.gov/39570804/},
}

@article{pmid39827882,
  title = {Mammalian nucleophagy: process and function.},
  author = {Ji F, Dai E, Kang R, Klionsky DJ, Liu T, Hu Y, Tang D, Zhu K},
  journal = {Autophagy},
  year = {2025},
  pmid = {39827882},
  doi = {10.1080/15548627.2025.2455158},
  url = {https://pubmed.ncbi.nlm.nih.gov/39827882/},
}

@article{pmid40221009,
  title = {Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: Mechanisms, challenges, and future directions.},
  author = {["Liu A", "Zhu X", "Sun W", "Bi S", "Zhang C", "Lai S", "Li J"]},
  journal = {Experimental neurology},
  year = {2025},
  pmid = {40221009},
  doi = {10.1016/j.expneurol.2025.115253},
}

@article{pmid40506775,
  title = {Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain-muscle-liver axis to slow down aging and neurodegeneration: a narrative review.},
  author = {["Kong J", "Xie Y", "Fan R", "Wang Q", "Luo Y", "Dong P"]},
  journal = {European journal of medical research},
  year = {2025},
  pmid = {40506775},
  doi = {10.1186/s40001-025-02751-9},
}

@article{pmid41268687,
  title = {AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy.},
  author = {Chen J, Liu B, Yao X, Yang X, Sun J, Yi J, Xue F, Zhang J, Shen Y, Chen B, Sun H},
  journal = {CNS neuroscience & therapeutics},
  year = {2025},
  pmid = {41268687},
  doi = {10.1111/cns.70657},
  url = {https://pubmed.ncbi.nlm.nih.gov/41268687/},
}

@article{pmid41268687,
  title = {AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy.},
  author = {Chen J, Liu B, Yao X, Yang X, Sun J et al.},
  journal = {CNS Neurosci Ther},
  year = {2025},
  pmid = {41268687},
  doi = {doi: 10.1111/cns.70657},
  url = {https://pubmed.ncbi.nlm.nih.gov/41268687/},
}

@article{pmid38279580,
  title = {Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury.},
  author = {Kang YY, Kim DY, Lee SY, Kim HJ, Kim T, Cho JA, Lee T, Choi EY},
  journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
  year = {2024},
  pmid = {38279580},
  doi = {10.1002/advs.202308978},
  url = {https://pubmed.ncbi.nlm.nih.gov/38279580/},
}

@article{pmid39128469,
  title = {SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2.},
  author = {Lian B, Zhang J, Yin X, Wang J, Li L, Ju Q, Wang Y, Jiang Y, Liu X, Chen Y, Tang X, Sun C},
  journal = {Cell reports. Medicine},
  year = {2024},
  pmid = {39128469},
  doi = {10.1016/j.xcrm.2024.101684},
  url = {https://pubmed.ncbi.nlm.nih.gov/39128469/},
}

@article{pmid39128469,
  title = {SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2.},
  author = {Lian B, Zhang J, Yin X, Wang J, Li L et al.},
  journal = {Cell Rep Med},
  year = {2024},
  pmid = {39128469},
  doi = {doi: 10.1016/j.xcrm.2024.101684},
  url = {https://pubmed.ncbi.nlm.nih.gov/39128469/},
}

@article{pmid39447038,
  title = {Late-Onset Caloric Restriction Improves Cognitive Performance and Restores Circadian Patterns of Neurotrophic, Clock, and Epigenetic Factors in the Hippocampus of Old Male Rats.},
  author = {["Altamirano F", "Castro-Pascual I", "Ponce I", "Coria-Lucero C", "Cargnelutti E", "Ferramola M", "Delgado M", "Anzulovich A", "Lacoste M"]},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year = {2024},
  pmid = {39447038},
  doi = {10.1093/gerona/glae252},
}

@article{pmid37456463,
  title = {The Role of Sirtuin 1 (SIRT1) in Neurodegeneration.},
  author = {["Razick D", "Akhtar M", "Wen J", "Alam M", "Dean N", "Karabala M", "Ansari U", "Ansari Z", "Tabaie E", "Siddiqui S"]},
  journal = {Cureus},
  year = {2023},
  pmid = {37456463},
  doi = {10.7759/cureus.40463},
}

@article{pmid37483618,
  title = {Sirtuin family in autoimmune diseases.},
  author = {Tao Z, Jin Z, Wu J, Cai G, Yu X},
  journal = {Frontiers in immunology},
  year = {2023},
  pmid = {37483618},
  doi = {10.3389/fimmu.2023.1186231},
  url = {https://pubmed.ncbi.nlm.nih.gov/37483618/},
}

@article{pmid35002516,
  title = {Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a.},
  author = {Wu H, Ma H, Wang L, Zhang H, Lu L, Xiao T, Cheng C, Wang P, Yang Y, Wu M, Wang S, Zhang J, Liu Q},
  journal = {International journal of biological sciences},
  year = {2022},
  pmid = {35002516},
  doi = {10.7150/ijbs.65861},
  url = {https://pubmed.ncbi.nlm.nih.gov/35002516/},
}

@article{pmid35116217,
  title = {Hippocampus and its involvement in Alzheimer's disease: a review.},
  author = {Rao YL, Ganaraja B, Murlimanju BV, Joy T, Krishnamurthy A, Agrawal A},
  journal = {3 Biotech},
  year = {2022},
  pmid = {35116217},
  doi = {10.1007/s13205-022-03123-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/35116217/},
}

@article{pmid35116217,
  title = {Hippocampus and its involvement in Alzheimer's disease: a review.},
  author = {Rao YL, Ganaraja B, Murlimanju BV, Joy T, Krishnamurthy A et al.},
  journal = {3 Biotech},
  year = {2022},
  pmid = {35116217},
  doi = {doi: 10.1007/s13205-022-03123-4},
  url = {https://pubmed.ncbi.nlm.nih.gov/35116217/},
}

@article{pmid35442559,
  title = {Protective effects of CHIP overexpression and Wharton's jelly mesenchymal-derived stem cell treatment against streptozotocin-induced neurotoxicity in rats.},
  author = {["Ju D", "Van Thao D", "Lu C", "Ali A", "Shibu M", "Chen R", "Day C", "Shih T", "Tsai C", "Kuo C"]},
  journal = {Environmental toxicology},
  year = {2022},
  pmid = {35442559},
  doi = {10.1002/tox.23544},
}

@article{pmid32985464,
  title = {Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1.},
  author = {["Maiese K"]},
  journal = {Neural regeneration research},
  year = {2021},
  pmid = {32985464},
  doi = {10.4103/1673-5374.291382},
}

@article{pmid33770194,
  title = {Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.},
  author = {Hammer SS, Vieira CP, McFarland D, Sandler M, Levitsky Y, Dorweiler TF, Lydic TA, Asare-Bediako B, Adu-Agyeiwaah Y, Sielski MS, Dupont M, Longhini AL, Li Calzi S, Chakraborty D, Seigel GM, Proshlyakov DA, Grant MB, Busik JV},
  journal = {Diabetologia},
  year = {2021},
  pmid = {33770194},
  doi = {10.1007/s00125-021-05431-5},
  url = {https://pubmed.ncbi.nlm.nih.gov/33770194/},
}

@article{pmid33852912,
  title = {Reducing acetylated tau is neuroprotective in brain injury.},
  author = {["Shin M", "V\u00e1zquez-Rosa E", "Koh Y", "Dhar M", "Chaubey K", "Cintr\u00f3n-P\u00e9rez C", "Barker S", "Miller E", "Franke K", "Noterman M"]},
  journal = {Cell},
  year = {2021},
  pmid = {33852912},
  doi = {10.1016/j.cell.2021.03.032},
}

@article{pmid33852912,
  title = {Reducing acetylated tau is neuroprotective in brain injury.},
  author = {Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K et al.},
  journal = {Cell},
  year = {2021},
  pmid = {33852912},
  doi = {doi: 10.1016/j.cell.2021.03.032},
  url = {https://pubmed.ncbi.nlm.nih.gov/33852912/},
}

@article{pmid34422879,
  title = {Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition.},
  author = {["Milo\u0161evi\u0107 M", "Arsi\u0107 A", "Cvetkovi\u0107 Z", "Vu\u010di\u0107 V"]},
  journal = {Frontiers in nutrition},
  year = {2021},
  pmid = {34422879},
  doi = {10.3389/fnut.2021.688086},
}

@article{pmid31368626,
  title = {From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs.},
  author = {["McIntyre R", "Daniels E", "Molenaars M", "Houtkooper R", "Janssens G"]},
  journal = {EMBO molecular medicine},
  year = {2019},
  pmid = {31368626},
  doi = {10.15252/emmm.201809854},
}

@article{pmid25281273,
  title = {Role of SIRT1 in autoimmune demyelination and neurodegeneration.},
  author = {["Martin A", "Tegla C", "Cudrici C", "Kruszewski A", "Azimzadeh P", "Boodhoo D", "Mekala A", "Rus V", "Rus H"]},
  journal = {Immunologic research},
  year = {2015},
  pmid = {25281273},
  doi = {10.1007/s12026-014-8557-5},
}

@article{pmid24624331,
  title = {Role of advanced glycation end products in cellular signaling.},
  author = {Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A},
  journal = {Redox biology},
  year = {2014},
  pmid = {24624331},
  doi = {10.1016/j.redox.2013.12.016},
  url = {https://pubmed.ncbi.nlm.nih.gov/24624331/},
}

@article{pmid24624331,
  title = {Role of advanced glycation end products in cellular signaling.},
  author = {Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T et al.},
  journal = {Redox Biol},
  year = {2014},
  pmid = {24624331},
  doi = {doi: 10.1016/j.redox.2013.12.016},
  url = {https://pubmed.ncbi.nlm.nih.gov/24624331/},
}

@article{pmid23417962,
  title = {SIRT1 and SIRT2: emerging targets in neurodegeneration.},
  author = {["Donmez G", "Outeiro T"]},
  journal = {EMBO molecular medicine},
  year = {2013},
  pmid = {23417962},
  doi = {10.1002/emmm.201302451},
}

@article{pmid21879453,
  title = {Sirtuin modulators.},
  author = {["Mahajan S", "Leko V", "Simon J", "Bedalov A"]},
  journal = {Handbook of experimental pharmacology},
  year = {2011},
  pmid = {21879453},
  doi = {10.1007/978-3-642-21631-2_11},
}