% Bibliography for hypothesis h-44195347
% Title: APOE4 Allosteric Rescue via Small Molecule Chaperones
% Generated: 2026-04-28T17:22:00Z

@article{pmid40145985,
  title = {Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders.},
  author = {Lozupone M, Leccisotti I, Mollica A, Berardino G, Moretti MC, Altamura M, Bellomo A, Daniele A, Dibello V, Solfrizzi V, Resta E, Panza F},
  journal = {Neural regeneration research},
  year = {2026},
  pmid = {40145985},
  doi = {10.4103/NRR.NRR-D-24-01274},
  url = {https://pubmed.ncbi.nlm.nih.gov/40145985/},
}

@article{pmid40562635,
  title = {Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.},
  author = {Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.},
  journal = {Br J Anaesth},
  year = {2026},
  pmid = {40562635},
  doi = {doi: 10.1016/j.bja.2025.05.014},
  url = {https://pubmed.ncbi.nlm.nih.gov/40562635/},
}

@article{pmid40615639,
  title = {Increased genetic protection against Alzheimer's disease in centenarians.},
  author = {Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.},
  journal = {Geroscience},
  year = {2026},
  pmid = {40615639},
  doi = {doi: 10.1007/s11357-025-01774-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/40615639/},
}

@article{pmid40864401,
  title = {Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.},
  author = {Stern A, Linial M},
  journal = {Geroscience},
  year = {2026},
  pmid = {40864401},
  doi = {doi: 10.1007/s11357-025-01828-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/40864401/},
}

@article{pmid41101204,
  title = {Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsules achieves effective combinatorial treatment of glioblastoma.},
  author = {Sang Y, Cao Y, Li S, Quan Y, Wang S et al.},
  journal = {Biomaterials},
  year = {2026},
  pmid = {41101204},
  doi = {doi: 10.1016/j.biomaterials.2025.123785},
  url = {https://pubmed.ncbi.nlm.nih.gov/41101204/},
}

@article{pmid41283974,
  title = {A ketogenic diet improves memory in females in the APOE4 mouse model of Alzheimer's disease.},
  author = {Di Lucente J, Rutkowsky JM, Errico Provenzano A, Persico G, Zhou Z, Jin LW, Ramsey JJ, Montgomery CB, Kim K, Giorgio M, Maezawa I, Cortopassi GA},
  journal = {GeroScience},
  year = {2026},
  pmid = {41283974},
  doi = {10.1007/s11357-025-01998-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41283974/},
}

@article{pmid41445196,
  title = {Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.},
  author = {Lin Z, Xiong J, Zhang F, Zhang H, Zhu M et al.},
  journal = {Mol Ther},
  year = {2026},
  pmid = {41445196},
  doi = {doi: 10.1016/j.ymthe.2025.12.035},
  url = {https://pubmed.ncbi.nlm.nih.gov/41445196/},
}

@article{pmid41531227,
  title = {Menopause, cognition, and Alzheimer's disease risk.},
  author = {Samudra N, Vemuri M, Weitlauf J},
  journal = {Curr Opin Obstet Gynecol},
  year = {2026},
  pmid = {41531227},
  doi = {doi: 10.1097/GCO.0000000000001087},
  url = {https://pubmed.ncbi.nlm.nih.gov/41531227/},
}

@article{pmid41565199,
  title = {DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy.},
  author = {Zheng L, Liang K, Peng Y, Jin M, Chen X et al.},
  journal = {J Mol Cell Cardiol},
  year = {2026},
  pmid = {41565199},
  doi = {doi: 10.1016/j.yjmcc.2026.01.006},
  url = {https://pubmed.ncbi.nlm.nih.gov/41565199/},
}

@article{pmid41867029,
  title = {Can we refute a role for infections in Alzheimer's disease pathogenesis?},
  author = {Chatila ZK, Duggan MR, Silberberg E, Fernandez J, Auber LA, Bradshaw EM, Schultek NM},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2026},
  pmid = {41867029},
  doi = {10.1002/alz.71288},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867029/},
}

@article{pmid41890452,
  title = {Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzheimer's Disease Neurodegeneration: A Systematic Review.},
  author = {Arriaga P, Vianna K, Montez C, Panariello B, Tran S, Rodrigues D, Porto Barboza E},
  journal = {Cureus},
  year = {2026},
  pmid = {41890452},
  doi = {10.7759/cureus.104127},
  url = {https://pubmed.ncbi.nlm.nih.gov/41890452/},
}

@article{pmid41899281,
  title = {Alzheimer's Disease: From Pathogenesis to Emerging Therapeutic Targets.},
  author = {Takahashi T, Muguruma K},
  journal = {Journal of clinical medicine},
  year = {2026},
  pmid = {41899281},
  doi = {10.3390/jcm15062357},
  url = {https://pubmed.ncbi.nlm.nih.gov/41899281/},
}

@article{pmid41905188,
  title = {Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease.},
  author = {Cetindag AC, Schipke CG, Esselmann H, Kruse N, Wiltfang J, Schneider A, Fliessbach K, Miklitz C, Maier F, Buerger K, Janowitz D, Ewers M, Stöcklein S, Perneczky R, Rauchmann BS, Kurz C, Teipel S, Kilimann I, Goerss D, Laske C, Sodenkamp S, Najafpour E, Wagner M, Roeske S, Frommann I, Stark M, Brosseron F, Ramirez A, Kleineidam L, Priller J},
  journal = {The journal of prevention of Alzheimer's disease},
  year = {2026},
  pmid = {41905188},
  doi = {10.1016/j.tjpad.2026.100544},
  url = {https://pubmed.ncbi.nlm.nih.gov/41905188/},
}

@article{pmid41905956,
  title = {Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease.},
  author = {Taniguchi M, Taruya A, Kitahara C, Ota S, Kato T, Desaki Y, Sasaki I, Katayama Y, Wada T, Takahata M, Satogami K, Ozaki Y, Kashiwagi M, Shiono Y, Honda K, Yamano T, Takemoto K, Kuroi A, Kitabata H, Hemmi H, Matsuoka T, Nishimura Y, Tanaka A},
  journal = {Circulation journal : official journal of the Japanese Circulation Society},
  year = {2026},
  pmid = {41905956},
  doi = {10.1253/circj.CJ-25-0829},
  url = {https://pubmed.ncbi.nlm.nih.gov/41905956/},
}

@article{pmid41911088,
  title = {Correlational Validity and Biomarker Associations of the Korean Computerized Cognitive Function Test (CFT-S) Relative to the Seoul Neuropsychological Screening Battery in MCI and Alzheimer's Disease.},
  author = {Kim D, Lee WJ, Jeon DH, Lee H, Kang M, Park M, Kim M, Ha S, Cho K},
  journal = {Dementia and geriatric cognitive disorders},
  year = {2026},
  pmid = {41911088},
  doi = {10.1159/000551744},
  url = {https://pubmed.ncbi.nlm.nih.gov/41911088/},
}

@article{pmid41912201,
  title = {Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 and Beta-Amyloid.},
  author = {Sabry HH, Kadhum BQ, Abdulmohsin GN, El-Ghafar AOA, Mahmoud MM, Shams GM},
  journal = {Dermatology practical & conceptual},
  year = {2026},
  pmid = {41912201},
  doi = {10.5826/dpc.1601a5957},
  url = {https://pubmed.ncbi.nlm.nih.gov/41912201/},
}

@article{pmid41914296,
  title = {ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL-Induced Foam Cells.},
  author = {Wu S, Han F, Qiao Z, Yuan S, Bian X, Zhang B, Dou K, Ma D},
  journal = {Frontiers in bioscience (Landmark edition)},
  year = {2026},
  pmid = {41914296},
  doi = {10.31083/FBL47686},
  url = {https://pubmed.ncbi.nlm.nih.gov/41914296/},
}

@article{pmid37805344,
  title = {The cell biology of APOE in the brain.},
  author = {Windham IA, Cohen S},
  journal = {Trends Cell Biol},
  year = {2024},
  pmid = {37805344},
  doi = {10.1016/j.tcb.2023.09.004},
  url = {https://pubmed.ncbi.nlm.nih.gov/37805344},
}

@article{pmid37995685,
  title = {Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.},
  author = {Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M},
  journal = {Neuron},
  year = {2024},
  pmid = {37995685},
  doi = {10.1016/j.neuron.2023.10.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/37995685},
}

@article{pmid38266641,
  title = {HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III.},
  author = {Leone S, Srivastava A, Herrero-Ruiz A, Hummel B, Tittel L, Campalastri R, Aprile-Garcia F, Tan JH, Rawat P, Andersson P, Willis AE, Sawarkar R},
  journal = {Molecular cell},
  year = {2024},
  pmid = {38266641},
  doi = {10.1016/j.molcel.2024.01.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/38266641/},
}

@article{pmid38507480,
  title = {Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection.},
  author = {["Yang F", "Beltran-Lobo P", "Sung K", "Goldrick C", "Croft C", "Nishimura A", "Hedges E", "Mahiddine F", "Troakes C", "Golde T"]},
  journal = {Science advances},
  year = {2024},
  pmid = {38507480},
  doi = {10.1126/sciadv.adk9884},
}

@article{pmid38507480,
  title = {Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection.},
  author = {Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL et al.},
  journal = {Sci Adv},
  year = {2024},
  pmid = {38507480},
  doi = {doi: 10.1126/sciadv.adk9884},
  url = {https://pubmed.ncbi.nlm.nih.gov/38507480/},
}

@article{pmid38594551,
  title = {Exploring key genes and pathways associated with sex differences in autism spectrum disorder: integrated bioinformatic analysis.},
  author = {["Nautiyal H", "Jaiswar A", "Jha P", "Dwivedi S"]},
  journal = {Mammalian genome : official journal of the International Mammalian Genome Society},
  year = {2024},
  pmid = {38594551},
  doi = {10.1007/s00335-024-10036-5},
}

@article{pmid38671323,
  title = {Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.},
  author = {["Theobald H", "Bejarano D", "Katzmarski N", "Haub J", "Schulte-Schrepping J", "Yu J", "Bassler K", "Ament A", "Osei-Sarpong C", "Piattini F"]},
  journal = {Nature immunology},
  year = {2024},
  pmid = {38671323},
  doi = {10.1038/s41590-024-01830-z},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Translational neurodegeneration},
  year = {2024},
  pmid = {39232848},
  doi = {10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Transl Neurodegener},
  year = {2024},
  pmid = {39232848},
  doi = {doi: 10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid37315033,
  title = {Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model.},
  author = {["Morito T", "Harada R", "Iwata R", "Ishikawa Y", "Okamura N", "Kudo Y", "Furumoto S", "Yanai K", "Tashiro M"]},
  journal = {PloS one},
  year = {2023},
  pmid = {37315033},
  doi = {10.1371/journal.pone.0287047},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Maxine R Nelson, Peng Liu, Ayushi Agrawal, Oscar Yip, Jessica Blumenfeld et al.},
  journal = {Nature neuroscience},
  year = {2023},
  pmid = {37957317},
  doi = {10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J et al.},
  journal = {Nat Neurosci},
  year = {2023},
  pmid = {37957317},
  doi = {doi: 10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317/},
}

@article{pmid34666101,
  title = {Imaging intracellular protein interactions/activity in neurons using 2-photon fluorescence lifetime imaging microscopy.},
  author = {["Ueda H", "Nagasawa Y", "Murakoshi H"]},
  journal = {Neuroscience research},
  year = {2022},
  pmid = {34666101},
  doi = {10.1016/j.neures.2021.10.004},
}

@article{pmid35659112,
  title = {Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases.},
  author = {Khalaf K, Tornese P, Cocco A, Albanese A},
  journal = {Translational neurodegeneration},
  year = {2022},
  pmid = {35659112},
  doi = {10.1186/s40035-022-00307-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/35659112/},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {doi: 10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485/},
}

@article{pmid33510301,
  title = {Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody.},
  author = {["Morito T", "Harada R", "Iwata R", "Du Y", "Okamura N", "Kudo Y", "Yanai K"]},
  journal = {Scientific reports},
  year = {2021},
  pmid = {33510301},
  doi = {10.1038/s41598-021-82037-2},
}

@article{pmid33891876,
  title = {Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.},
  author = {["Bourdenx M", "Mart\u00edn-Segura A", "Scrivo A", "Rodriguez-Navarro J", "Kaushik S", "Tasset I", "Diaz A", "Storm N", "Xin Q", "Juste Y"]},
  journal = {Cell},
  year = {2021},
  pmid = {33891876},
  doi = {10.1016/j.cell.2021.03.048},
}

@article{pmid31706733,
  title = {The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis.},
  author = {["Tolar M", "Abushakra S", "Sabbagh M"]},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2020},
  pmid = {31706733},
  doi = {10.1016/j.jalz.2019.09.075},
}

@article{pmid32380205,
  title = {ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice.},
  author = {["Wang Q", "Kumar V", "Lin F", "Sethi B", "Coulter D", "McGuire T", "Mahato R"]},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year = {2020},
  pmid = {32380205},
  doi = {10.1016/j.jconrel.2020.04.053},
}

@article{pmid30335591,
  title = {Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.},
  author = {Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E},
  journal = {Autophagy},
  year = {2019},
  pmid = {30335591},
  doi = {10.1080/15548627.2018.1535292},
  url = {https://pubmed.ncbi.nlm.nih.gov/30335591},
}

@article{pmid31367008,
  title = {Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.},
  author = {Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G},
  journal = {Nat Rev Neurol},
  year = {2019},
  pmid = {31367008},
  doi = {10.1038/s41582-019-0228-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/31367008},
}

@article{pmid31367008,
  title = {Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.},
  author = {Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G},
  journal = {Nat Rev Neurol},
  year = {2019},
  pmid = {31367008},
  doi = {doi: 10.1038/s41582-019-0228-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/31367008/},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456},
}

@article{pmid31564456,
  title = {Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.},
  author = {Long JM, Holtzman DM},
  journal = {Cell},
  year = {2019},
  pmid = {31564456},
  doi = {doi: 10.1016/j.cell.2019.09.001},
  url = {https://pubmed.ncbi.nlm.nih.gov/31564456/},
}

@article{pmid27097127,
  title = {Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases.},
  author = {["Convertino M", "Das J", "Dokholyan N"]},
  journal = {ACS chemical biology},
  year = {2016},
  pmid = {27097127},
  doi = {10.1021/acschembio.6b00195},
}

@article{pmid27365453,
  title = {In vivo aspects of protein folding and quality control.},
  author = {["Balchin D", "Hayer-Hartl M", "Hartl F"]},
  journal = {Science (New York, N.Y.)},
  year = {2016},
  pmid = {27365453},
  doi = {10.1126/science.aac4354},
}

@article{pmid24550672,
  title = {Nanoscale drug delivery systems and the blood-brain barrier.},
  author = {["Alyautdin R", "Khalin I", "Nafeeza M", "Haron M", "Kuznetsov D"]},
  journal = {International journal of nanomedicine},
  year = {2014},
  pmid = {24550672},
  doi = {10.2147/IJN.S52236},
}

@article{pmid23296339,
  title = {Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.},
  author = {Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G},
  journal = {Nature reviews. Neurology},
  year = {2013},
  pmid = {23296339},
  doi = {10.1038/nrneurol.2012.263},
  url = {https://pubmed.ncbi.nlm.nih.gov/23296339/},
}

@article{pmid23296339,
  title = {Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.},
  author = {Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G},
  journal = {Nat Rev Neurol},
  year = {2013},
  pmid = {23296339},
  doi = {doi: 10.1038/nrneurol.2012.263},
  url = {https://pubmed.ncbi.nlm.nih.gov/23296339/},
}