% Bibliography for hypothesis h-3460f820
% Title: TREM2-Mediated Selective Aggregate Clearance Pathway
% Generated: 2026-04-28T19:17:19Z

@article{pmid41435973,
  title = {AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validation.},
  author = {Cho S, Zhu R, Kuncewicz K, Duan H, Gabr M},
  journal = {Bioorg Med Chem Lett},
  year = {2026},
  pmid = {41435973},
  doi = {doi: 10.1016/j.bmcl.2025.130512},
  url = {https://pubmed.ncbi.nlm.nih.gov/41435973/},
}

@article{pmid41643896,
  title = {Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Function and Exacerbates Retinal Neurodegeneration in Glaucoma.},
  author = {Chen G, Wang Z, Zhao C, Wang C, Li Y et al.},
  journal = {Am J Pathol},
  year = {2026},
  pmid = {41643896},
  doi = {doi: 10.1016/j.ajpath.2026.01.009},
  url = {https://pubmed.ncbi.nlm.nih.gov/41643896/},
}

@article{pmid41651180,
  title = {Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications.},
  author = {Yang FG, Yang H, Han SW, Wang JT, Gao W et al.},
  journal = {Ageing Res Rev},
  year = {2026},
  pmid = {41651180},
  doi = {doi: 10.1016/j.arr.2026.103050},
  url = {https://pubmed.ncbi.nlm.nih.gov/41651180/},
}

@article{pmid41678917,
  title = {Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's disease: Metabolite signaling, neuroimmune circuits, and systems-level regulation.},
  author = {Xue D, Hu X, Li R, Sun T, Qian S et al.},
  journal = {Phytomedicine},
  year = {2026},
  pmid = {41678917},
  doi = {doi: 10.1016/j.phymed.2026.157919},
  url = {https://pubmed.ncbi.nlm.nih.gov/41678917/},
}

@article{pmid41792456,
  title = {TREM2 in neurodegeneration and diseases.},
  author = {["Abdulkhaliq A", "Alasiri G", "Kim B", "Khan J", "Ajoolabady A", "Yousof S", "Ren J", "Tuomilehto J", "Borai A", "Alrfaei B"]},
  journal = {Molecular psychiatry},
  year = {2026},
  pmid = {41792456},
  doi = {10.1038/s41380-026-03505-7},
}

@article{pmid41833769,
  title = {Targeting TREM2 to disentangle neuroinflammation and α-Syn pathological propagation in Parkinson's disease.},
  author = {Chen Y, Wang H, Wang J, Wei J},
  journal = {Cellular signalling},
  year = {2026},
  pmid = {41833769},
  doi = {10.1016/j.cellsig.2026.112485},
  url = {https://pubmed.ncbi.nlm.nih.gov/41833769/},
}

@article{pmid41920402,
  title = {Increased plasma soluble TREM2 levels in non-Alzheimer's dementia.},
  author = {Güven Gamze; Gezegen Haşim; Şahin Erdi; Samancı Bedia; Hanağası Haşmet; Gürvit Hakan; Alaylıoğlu Merve; Gezen-Ak Duygu; Dursun Erdinç; Bilgiç Başar},
  journal = {Acta neurologica Belgica},
  year = {2026},
  pmid = {41920402},
  doi = {10.1007/s13760-026-03042-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41920402/},
}

@article{pmid41928407,
  title = {Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell Levels in Bleomycin-Induced Pulmonary Fibrosis.},
  author = {Shen HC, Chen NJ, Sun CY, Yu WK, Su VY et al.},
  journal = {Kaohsiung J Med Sci},
  year = {2026},
  pmid = {41928407},
  doi = {doi: 10.1002/kjm2.70209},
  url = {https://pubmed.ncbi.nlm.nih.gov/41928407/},
}

@article{pmid41930604,
  title = {TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.},
  author = {Yang HC, Deng YS, Zhang J, Zhang T, Song W et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930604},
  doi = {doi: 10.1177/13872877261437264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930604/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year = {2025},
  pmid = {38769824},
  doi = {10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {Neuroscientist},
  year = {2025},
  pmid = {38769824},
  doi = {doi: 10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid41261421,
  title = {Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils.},
  author = {Etani H, Takatori S, Wang W, Omi J, Amiya Y, Akahori A, Watanabe H, Sonn I, Okano H, Hara N, Hasegawa M, Miyashita A, Kikuchi M, Ikeuchi T, Morishima M, Saito Y, Murayama S, Saito T, Saido TC, Takai T, Ohwada T, Aoki J, Tomita T},
  journal = {Alzheimer's research & therapy},
  year = {2025},
  pmid = {41261421},
  doi = {10.1186/s13195-025-01891-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41261421/},
}

@article{pmid36368315,
  title = {TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.},
  author = {Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM},
  journal = {Neuron},
  year = {2023},
  pmid = {36368315},
  doi = {10.1016/j.neuron.2022.10.022},
  url = {https://pubmed.ncbi.nlm.nih.gov/36368315/},
}

@article{pmid37442133,
  title = {TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.},
  author = {Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF},
  journal = {Immunity},
  year = {2023},
  pmid = {37442133},
  doi = {10.1016/j.immuni.2023.06.016},
  url = {https://pubmed.ncbi.nlm.nih.gov/37442133/},
}

@article{pmid37796590,
  title = {Too naïve to lead: When leaders fall for flattery.},
  author = {Rogers BA, Sezer O, Klein N},
  journal = {Journal of personality and social psychology},
  year = {2023},
  pmid = {37796590},
  doi = {10.1037/pspi0000433},
  url = {https://pubmed.ncbi.nlm.nih.gov/37796590/},
}

@article{pmid34916658,
  title = {TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.},
  author = {Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ},
  journal = {Nature neuroscience},
  year = {2022},
  pmid = {34916658},
  doi = {10.1038/s41593-021-00975-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/34916658/},
}

@article{pmid35672148,
  title = {Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the },
  author = {["Shi Qian", "Chang Cheng", "Saliba Afaf", "Bhat Manzoor A"]},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year = {2022},
  pmid = {35672148},
  doi = {10.1084/jem.20160844},
}

@article{pmid33028628,
  title = {Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions.},
  author = {Luhur A, Mariyappa D, Klueg KM, Buddika K, Tennessen JM, Zelhof AC},
  journal = {G3 (Bethesda, Md.)},
  year = {2020},
  pmid = {33028628},
  doi = {10.1534/g3.120.401769},
  url = {https://pubmed.ncbi.nlm.nih.gov/33028628/},
}

@article{pmid30206353,
  title = {Reverse pre-symptomatic testing for Huntington disease: double disclosure when 25% at-risk children reveal the genetic status to their parent.},
  author = {Bonnard A, Herson A, Gargiulo M, Durr A},
  journal = {European journal of human genetics : EJHG},
  year = {2019},
  pmid = {30206353},
  doi = {10.1038/s41431-018-0255-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/30206353/},
}

@article{pmid31235687,
  title = {Author Correction: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer.},
  author = {Hao XL, Gao LY, Deng XJ, Han F, Chen HQ, Jiang X, Liu WB, Wang DD, Chen JP, Cui ZH, Ao L, Cao J, Liu JY},
  journal = {Cell death & disease},
  year = {2019},
  pmid = {31235687},
  doi = {10.1038/s41419-019-1726-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/31235687/},
}

@article{pmid31261156,
  title = {Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome.},
  author = {Presta V, Miceli F, Tocci G},
  journal = {Cardiology},
  year = {2019},
  pmid = {31261156},
  doi = {10.1159/000500321},
  url = {https://pubmed.ncbi.nlm.nih.gov/31261156/},
}

@article{pmid31427474,
  title = {Air in the lung: can you spot them?},
  author = {Cho-Han Chiang; Cho-Hung Chiang; Cho-Hsien Chiang},
  journal = {Emergency medicine journal : EMJ},
  year = {2019},
  pmid = {31427474},
  doi = {10.1136/emermed-2019-208657},
  url = {https://pubmed.ncbi.nlm.nih.gov/31427474/},
}

@article{pmid31591459,
  title = {Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study.},
  author = {Zheng J, Xie SH, Santoni G, Lagergren J},
  journal = {British journal of cancer},
  year = {2019},
  pmid = {31591459},
  doi = {10.1038/s41416-019-0598-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/31591459/},
}

@article{pmid28602351,
  title = {A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.},
  author = {["Keren-Shaul H", "Spinrad A", "Weiner A", "Matcovitch-Natan O", "Dvir-Szternfeld R", "Ulland TK", "David E", "Baruch K", "Lara-Astaiso D", "Toth B", "Itzkovitz S", "Colonna M", "Schwartz M", "Amit I"]},
  journal = {Cell},
  year = {2017},
  pmid = {28602351},
  doi = {10.1016/j.cell.2017.05.018},
  url = {https://pubmed.ncbi.nlm.nih.gov/28602351/},
}