% Bibliography for hypothesis h-23a3cc07
% Title: Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation
% Generated: 2026-04-27T16:29:49Z

@article{pmid41197818,
  title = {ROS-responsive nanogels for brain targeted delivery of icariin in the treatment of Parkinson's disease.},
  author = {["Li X", "Huang J", "Zhou Y", "Chen X", "Dong Q", "Cui Y", "Chen Y"]},
  journal = {International journal of pharmaceutics},
  year = {2026},
  pmid = {41197818},
  doi = {10.1016/j.ijpharm.2025.126361},
}

@article{pmid41338456,
  title = {A humanized transferrin receptor 1-transferrin model supports functional iron homeostasis and therapeutic delivery across the blood-brain barrier.},
  author = {Yesiltepe M, Metkar S, Yin T, Chakraborty I, D'Adamio L},
  journal = {The Journal of biological chemistry},
  year = {2026},
  pmid = {41338456},
  doi = {10.1016/j.jbc.2025.110995},
  url = {https://pubmed.ncbi.nlm.nih.gov/41338456/},
}

@article{pmid41755010,
  title = {Impact of Neonatal Fc Receptor on Transferrin Receptor Antibody Fusion Protein Pharmacokinetics.},
  author = {["Oyegbesan A", "Jagadeesan N", "Chandrashekar D", "Sumbria R"]},
  journal = {Pharmaceutics},
  year = {2026},
  pmid = {41755010},
  doi = {10.3390/pharmaceutics18020269},
}

@article{pmid39676023,
  title = {A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology.},
  author = {["Sehlin D", "Roshanbin S", "Zachrisson O", "Ingelsson M", "Syv\u00e4nen S"]},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year = {2025},
  pmid = {39676023},
  doi = {10.1016/j.neurot.2024.e00510},
}

@article{pmid40020261,
  title = {A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity.},
  author = {Ana-Sosa-Batiz F, Verma SK, Shafee N, Miller R, Conner C, Hastie KM, Timis J, Maule E, Nguyen MN, Tran L},
  journal = {EBioMedicine},
  year = {2025},
  pmid = {40020261},
  doi = {10.1016/j.ebiom.2025.105619},
  url = {https://pubmed.ncbi.nlm.nih.gov/40020261},
}

@article{pmid40403225,
  title = {Development of a Novel Engineered Antibody Format for PSMA-Targeted Radionuclide Therapy.},
  author = {["Fletcher N", "Houston Z", "Chandler P", "Yan E", "Holgate R", "Wheatcroft M", "Thurecht K"]},
  journal = {Molecular pharmaceutics},
  year = {2025},
  pmid = {40403225},
  doi = {10.1021/acs.molpharmaceut.4c01193},
}

@article{pmid40425446,
  title = {Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease.},
  author = {Sehlin D, Hultqvist G, Michno W, Aguilar X, Dahlén AD, Cerilli E, Bucher NM, Lopes van den Broek S, Syvänen S},
  journal = {J Prev Alzheimers Dis},
  year = {2025},
  pmid = {40425446},
  doi = {10.1016/j.tjpad.2025.100214},
  url = {https://pubmed.ncbi.nlm.nih.gov/40425446},
}

@article{pmid40533746,
  title = {Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges.},
  author = {["Sanadgol N", "Abedi M", "Hashemzaei M", "Kamran Z", "Khalseh R", "Beyer C", "Voelz C"]},
  journal = {Journal of nanobiotechnology},
  year = {2025},
  pmid = {40533746},
  doi = {10.1186/s12951-025-03528-2},
}

@article{pmid40715281,
  title = {Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies.},
  author = {Lee S, Kyung M, Park M, Park S, Lee J, Kim S, Lee S, Jo M, Jung ST, Lee HW},
  journal = {Scientific reports},
  year = {2025},
  pmid = {40715281},
  doi = {10.1038/s41598-025-11168-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/40715281/},
}

@article{pmid40807149,
  title = {Redefining Treatment Paradigms in Thyroid Eye Disease: Current and Future Therapeutic Strategies.},
  author = {["Ciarmatori N", "Quaranta Leoni F", "Quaranta Leoni F"]},
  journal = {Journal of clinical medicine},
  year = {2025},
  pmid = {40807149},
  doi = {10.3390/jcm14155528},
}

@article{pmid41031862,
  title = {Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.},
  author = {["Guo K", "Cao D", "Marchese-Thomas L", "Dong Y"]},
  journal = {Bioconjugate chemistry},
  year = {2025},
  pmid = {41031862},
  doi = {10.1021/acs.bioconjchem.5c00379},
}

@article{pmid41110474,
  title = {Novel single-domain antibodies targeting a unique transferrin receptor 1 epitope for cross-species delivery of drugs in the central nervous system.},
  author = {["David M", "Cohen R", "Beuzelin D", "Ferracci G", "Cresci M", "Faucon A", "Abouzid K", "Godefroy G", "Masse M", "Mechioukhi Y"]},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year = {2025},
  pmid = {41110474},
  doi = {10.1016/j.jconrel.2025.114344},
}

@article{pmid41199078,
  title = {Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next-Generation Therapies.},
  author = {["Ranjitha V", "Kumar A", "Kaalappa P"]},
  journal = {Pharmaceutical research},
  year = {2025},
  pmid = {41199078},
  doi = {10.1007/s11095-025-03941-0},
}

@article{pmid38494152,
  title = {RNA therapies for CNS diseases.},
  author = {["Di Francesco V", "Chua A", "Huang D", "D'Souza A", "Yang A", "Bleier B", "Amiji M"]},
  journal = {Advanced drug delivery reviews},
  year = {2024},
  pmid = {38494152},
  doi = {10.1016/j.addr.2024.115283},
}

@article{pmid39715817,
  title = {A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro.},
  author = {["Petersen I", "Morrison J", "Petrovic A", "Babic N", "Metzendorf N", "Godec A", "de la Rosa A", "Rofo F", "Bondza S", "Buijs J"]},
  journal = {Scientific reports},
  year = {2024},
  pmid = {39715817},
  doi = {10.1038/s41598-024-83627-6},
}

@article{pmid37932271,
  title = {An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission.},
  author = {["Li W", "Wang T", "Rajendrakumar A", "Acharya G", "Miao Z", "Varghese B", "Yu H", "Dhakal B", "LeRoith T", "Karunakaran A"]},
  journal = {Nature communications},
  year = {2023},
  pmid = {37932271},
  doi = {10.1038/s41467-023-42796-0},
}

@article{pmid38007619,
  title = {Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery.},
  author = {["Choi E", "Shusta E"]},
  journal = {Expert opinion on drug delivery},
  year = {2023},
  pmid = {38007619},
  doi = {10.1080/17425247.2023.2286371},
}

@article{pmid35639288,
  title = {Pharmacotherapy of Generalized Myasthenia Gravis with Special Emphasis on Newer Biologicals.},
  author = {["Menon D", "Bril V"]},
  journal = {Drugs},
  year = {2022},
  pmid = {35639288},
  doi = {10.1007/s40265-022-01726-y},
}

@article{pmid35890374,
  title = {IgG Fusion Proteins for Brain Delivery of Biologics via Blood-Brain Barrier Receptor-Mediated Transport.},
  author = {["Boado R"]},
  journal = {Pharmaceutics},
  year = {2022},
  pmid = {35890374},
  doi = {10.3390/pharmaceutics14071476},
}

@article{pmid36077002,
  title = {Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review.},
  author = {["Ramdani Y", "Lamamy J", "Watier H", "Gouilleux-Gruart V"]},
  journal = {International journal of molecular sciences},
  year = {2022},
  pmid = {36077002},
  doi = {10.3390/ijms23179604},
}

@article{pmid36257298,
  title = {Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis.},
  author = {["Edavettal S", "Cejudo-Martin P", "Dasgupta B", "Yang D", "Buschman M", "Domingo D", "Van Kolen K", "Jaiprasat P", "Gordon R", "Schutsky K"]},
  journal = {Med (New York, N.Y.)},
  year = {2022},
  pmid = {36257298},
  doi = {10.1016/j.medj.2022.09.007},
}

@article{pmid36346674,
  title = {Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy.},
  author = {["Hammond S", "Abendroth F", "Goli L", "Stoodley J", "Burrell M", "Thom G", "Gurrell I", "Ahlskog N", "Gait M", "Wood M"]},
  journal = {JCI insight},
  year = {2022},
  pmid = {36346674},
  doi = {10.1172/jci.insight.154142},
}

@article{pmid33717213,
  title = {The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors.},
  author = {Dalakas MC, Spaeth PJ},
  journal = {Ther Adv Neurol Disord},
  year = {2021},
  pmid = {33717213},
  doi = {10.1177/1756286421997381},
  url = {https://pubmed.ncbi.nlm.nih.gov/33717213},
}

@article{pmid32461332,
  title = {Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.},
  author = {["Kariolis M", "Wells R", "Getz J", "Kwan W", "Mahon C", "Tong R", "Kim D", "Srivastava A", "Bedard C", "Henne K"]},
  journal = {Science translational medicine},
  year = {2020},
  pmid = {32461332},
  doi = {10.1126/scitranslmed.aay1359},
}

@article{pmid33025844,
  title = {Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.},
  author = {Low BE, Christianson GJ, Lowell E, Qin W, Wiles MV},
  journal = {MAbs},
  year = {2020},
  pmid = {33025844},
  doi = {10.1080/19420862.2020.1829334},
  url = {https://pubmed.ncbi.nlm.nih.gov/33025844},
}

@article{pmid31342134,
  title = {Engineered antibodies: new possibilities for brain PET?},
  author = {Sehlin D, Syvänen S, MINC faculty},
  journal = {European journal of nuclear medicine and molecular imaging},
  year = {2019},
  pmid = {31342134},
  doi = {10.1007/s00259-019-04426-0},
  url = {https://pubmed.ncbi.nlm.nih.gov/31342134/},
}

@article{pmid28785825,
  title = {Functional polymorphisms in rhesus macaque FCGRT and β2-m.},
  author = {Shubin Z, Tagaya Y, Poonia B},
  journal = {Immunogenetics},
  year = {2018},
  pmid = {28785825},
  doi = {10.1007/s00251-017-1022-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/28785825/},
}

@article{pmid26687840,
  title = {Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.},
  author = {["Zuchero Y", "Chen X", "Bien-Ly N", "Bumbaca D", "Tong R", "Gao X", "Zhang S", "Hoyte K", "Luk W", "Huntley M"]},
  journal = {Neuron},
  year = {2016},
  pmid = {26687840},
  doi = {10.1016/j.neuron.2015.11.024},
}

@article{pmid26864109,
  title = {Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.},
  author = {["Igawa T", "Haraya K", "Hattori K"]},
  journal = {Immunological reviews},
  year = {2016},
  pmid = {26864109},
  doi = {10.1111/imr.12392},
}

@article{pmid25658443,
  title = {The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.},
  author = {["Abdiche Y", "Yeung Y", "Chaparro-Riggers J", "Barman I", "Strop P", "Chin S", "Pham A", "Bolton G", "McDonough D", "Lindquist K"]},
  journal = {mAbs},
  year = {2015},
  pmid = {25658443},
  doi = {10.1080/19420862.2015.1008353},
}

@article{pmid24411731,
  title = {Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.},
  author = {["Niewoehner J", "Bohrmann B", "Collin L", "Urich E", "Sade H", "Maier P", "Rueger P", "Stracke J", "Lau W", "Tissot A"]},
  journal = {Neuron},
  year = {2014},
  pmid = {24411731},
  doi = {10.1016/j.neuron.2013.10.061},
}

@article{pmid24411731,
  title = {Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.},
  author = {Niewoehner J, Bohrmann B, Collin L},
  journal = {Neuron},
  year = {2014},
  pmid = {24411731},
}

@article{pmid23978455,
  title = {Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.},
  author = {["Cooper P", "Ciambrone G", "Kliwinski C", "Maze E", "Johnson L", "Li Q", "Feng Y", "Hornby P"]},
  journal = {Brain research},
  year = {2013},
  pmid = {23978455},
  doi = {10.1016/j.brainres.2013.08.035},
}

@article{pmid21613623,
  title = {Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.},
  author = {["Yu Y", "Zhang Y", "Kenrick M", "Hoyte K", "Luk W", "Lu Y", "Atwal J", "Elliott J", "Prabhu S", "Watts R"]},
  journal = {Science translational medicine},
  year = {2011},
  pmid = {21613623},
  doi = {10.1126/scitranslmed.3002230},
}

@article{pmid20930418,
  title = {Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.},
  author = {Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada J, Kawasaki N, Yamaguchi T, Nakajima TE, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi T, Okuda H, Matsumura Y},
  journal = {Drug metabolism and pharmacokinetics},
  year = {2010},
  pmid = {20930418},
  doi = {10.2133/dmpk.dmpk-10-rg-067},
  url = {https://pubmed.ncbi.nlm.nih.gov/20930418/},
}

@article{pmid16186811,
  title = {Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.},
  author = {["Vaccaro C", "Zhou J", "Ober R", "Ward E"]},
  journal = {Nature biotechnology},
  year = {2005},
  pmid = {16186811},
  doi = {10.1038/nbt1143},
}