% Bibliography for hypothesis h-180807e5
% Title: APOE-TREM2 Interaction Modulation
% Generated: 2026-04-28T19:17:01Z

@article{pmid41435973,
  title = {AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validation.},
  author = {Cho S, Zhu R, Kuncewicz K, Duan H, Gabr M},
  journal = {Bioorg Med Chem Lett},
  year = {2026},
  pmid = {41435973},
  doi = {doi: 10.1016/j.bmcl.2025.130512},
  url = {https://pubmed.ncbi.nlm.nih.gov/41435973/},
}

@article{pmid41643896,
  title = {Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Function and Exacerbates Retinal Neurodegeneration in Glaucoma.},
  author = {Chen G, Wang Z, Zhao C, Wang C, Li Y et al.},
  journal = {Am J Pathol},
  year = {2026},
  pmid = {41643896},
  doi = {doi: 10.1016/j.ajpath.2026.01.009},
  url = {https://pubmed.ncbi.nlm.nih.gov/41643896/},
}

@article{pmid41651180,
  title = {Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications.},
  author = {Yang FG, Yang H, Han SW, Wang JT, Gao W et al.},
  journal = {Ageing Res Rev},
  year = {2026},
  pmid = {41651180},
  doi = {doi: 10.1016/j.arr.2026.103050},
  url = {https://pubmed.ncbi.nlm.nih.gov/41651180/},
}

@article{pmid41655546,
  title = {Eicosapentaenoic acid attenuates heart failure with preserved ejection fraction via promoting TREM2-dependent efferocytosis.},
  author = {Xie Y, He H, Li Y, Chen Q, Fu S et al.},
  journal = {Phytomedicine},
  year = {2026},
  pmid = {41655546},
  doi = {doi: 10.1016/j.phymed.2026.157886},
  url = {https://pubmed.ncbi.nlm.nih.gov/41655546/},
}

@article{pmid41678917,
  title = {Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's disease: Metabolite signaling, neuroimmune circuits, and systems-level regulation.},
  author = {Xue D, Hu X, Li R, Sun T, Qian S et al.},
  journal = {Phytomedicine},
  year = {2026},
  pmid = {41678917},
  doi = {doi: 10.1016/j.phymed.2026.157919},
  url = {https://pubmed.ncbi.nlm.nih.gov/41678917/},
}

@article{pmid41750155,
  title = {Neuroimmune Interactions in Neurodegeneration: The Role of Microglia in Alzheimer's and Parkinson's Disease Pathogenesis.},
  author = {["Goyal Pradeep", "Baldaniya Lalji", "Tyagi Lalit Kumar", "Joshi Kamal Kant", "Ballal Suhas"]},
  journal = {Brain sciences},
  year = {2026},
  pmid = {41750155},
  doi = {10.26599/FSHW.2024.9250066},
}

@article{pmid41792456,
  title = {TREM2 in neurodegeneration and diseases.},
  author = {["Abdulkhaliq A", "Alasiri G", "Kim B", "Khan J", "Ajoolabady A", "Yousof S", "Ren J", "Tuomilehto J", "Borai A", "Alrfaei B"]},
  journal = {Molecular psychiatry},
  year = {2026},
  pmid = {41792456},
  doi = {10.1038/s41380-026-03505-7},
}

@article{pmid41867790,
  title = {Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927.},
  author = {Cho S, Gabr MT},
  journal = {bioRxiv : the preprint server for biology},
  year = {2026},
  pmid = {41867790},
  doi = {10.64898/2026.03.02.709194},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867790/},
}

@article{pmid41890852,
  title = {Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) on Bone Structure in Male and Female Mice: Insights from the Four Core Genotypes mice.},
  author = {["Ramirez G", "Hernandez D", "Teal A", "Chellaganapathy L", "Pianeta R", "Segvich D", "Wallace J", "Plotkin L"]},
  journal = {Research square},
  year = {2026},
  pmid = {41890852},
  doi = {10.21203/rs.3.rs-9076483/v1},
}

@article{pmid41920402,
  title = {Increased plasma soluble TREM2 levels in non-Alzheimer's dementia.},
  author = {Güven Gamze; Gezegen Haşim; Şahin Erdi; Samancı Bedia; Hanağası Haşmet; Gürvit Hakan; Alaylıoğlu Merve; Gezen-Ak Duygu; Dursun Erdinç; Bilgiç Başar},
  journal = {Acta neurologica Belgica},
  year = {2026},
  pmid = {41920402},
  doi = {10.1007/s13760-026-03042-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/41920402/},
}

@article{pmid41930604,
  title = {TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.},
  author = {Yang HC, Deng YS, Zhang J, Zhang T, Song W et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930604},
  doi = {doi: 10.1177/13872877261437264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930604/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year = {2025},
  pmid = {38769824},
  doi = {10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid38769824,
  title = {Microglia, Trem2, and Neurodegeneration.},
  author = {Shi Q, Gutierrez RA, Bhat MA},
  journal = {Neuroscientist},
  year = {2025},
  pmid = {38769824},
  doi = {doi: 10.1177/10738584241254118},
  url = {https://pubmed.ncbi.nlm.nih.gov/38769824/},
}

@article{pmid36368315,
  title = {TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.},
  author = {Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM},
  journal = {Neuron},
  year = {2023},
  pmid = {36368315},
  doi = {10.1016/j.neuron.2022.10.022},
  url = {https://pubmed.ncbi.nlm.nih.gov/36368315/},
}

@article{pmid37442133,
  title = {TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.},
  author = {Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF},
  journal = {Immunity},
  year = {2023},
  pmid = {37442133},
  doi = {10.1016/j.immuni.2023.06.016},
  url = {https://pubmed.ncbi.nlm.nih.gov/37442133/},
}

@article{pmid34916658,
  title = {TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.},
  author = {Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ},
  journal = {Nature neuroscience},
  year = {2022},
  pmid = {34916658},
  doi = {10.1038/s41593-021-00975-6},
  url = {https://pubmed.ncbi.nlm.nih.gov/34916658/},
}

@article{pmid35663962,
  title = {The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease.},
  author = {Qin Q, Wang M, Yin Y, Tang Y},
  journal = {Frontiers in immunology},
  year = {2022},
  pmid = {35663962},
  doi = {10.3389/fimmu.2022.845897},
  url = {https://pubmed.ncbi.nlm.nih.gov/35663962/},
}

@article{pmid33028628,
  title = {Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions.},
  author = {Luhur A, Mariyappa D, Klueg KM, Buddika K, Tennessen JM, Zelhof AC},
  journal = {G3 (Bethesda, Md.)},
  year = {2020},
  pmid = {33028628},
  doi = {10.1534/g3.120.401769},
  url = {https://pubmed.ncbi.nlm.nih.gov/33028628/},
}

@article{pmid33066368,
  title = {Microglia in Alzheimer's Disease in the Context of Tau Pathology.},
  author = {["Perea Juan Ram\u00f3n", "Bol\u00f3s Marta", "Avila Jes\u00fas"]},
  journal = {Biomolecules},
  year = {2020},
  pmid = {33066368},
  doi = {10.1038/s41586-019-1088-4},
}

@article{pmid31261156,
  title = {Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome.},
  author = {Presta V, Miceli F, Tocci G},
  journal = {Cardiology},
  year = {2019},
  pmid = {31261156},
  doi = {10.1159/000500321},
  url = {https://pubmed.ncbi.nlm.nih.gov/31261156/},
}

@article{pmid31591459,
  title = {Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study.},
  author = {Zheng J, Xie SH, Santoni G, Lagergren J},
  journal = {British journal of cancer},
  year = {2019},
  pmid = {31591459},
  doi = {10.1038/s41416-019-0598-z},
  url = {https://pubmed.ncbi.nlm.nih.gov/31591459/},
}