% Bibliography for hypothesis h-11795af0
% Title: Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)
% Generated: 2026-04-27T16:44:41Z

@article{pmid40145985,
  title = {Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders.},
  author = {Lozupone M, Leccisotti I, Mollica A, Berardino G, Moretti MC, Altamura M, Bellomo A, Daniele A, Dibello V, Solfrizzi V, Resta E, Panza F},
  journal = {Neural regeneration research},
  year = {2026},
  pmid = {40145985},
  doi = {10.4103/NRR.NRR-D-24-01274},
  url = {https://pubmed.ncbi.nlm.nih.gov/40145985/},
}

@article{pmid40358463,
  title = {Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions.},
  author = {["Munavar-K F", "Lenka N"]},
  journal = {Tissue barriers},
  year = {2026},
  pmid = {40358463},
  doi = {10.1080/21688370.2025.2504738},
}

@article{pmid40562635,
  title = {Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.},
  author = {Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.},
  journal = {Br J Anaesth},
  year = {2026},
  pmid = {40562635},
  doi = {doi: 10.1016/j.bja.2025.05.014},
  url = {https://pubmed.ncbi.nlm.nih.gov/40562635/},
}

@article{pmid40615639,
  title = {Increased genetic protection against Alzheimer's disease in centenarians.},
  author = {Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.},
  journal = {Geroscience},
  year = {2026},
  pmid = {40615639},
  doi = {doi: 10.1007/s11357-025-01774-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/40615639/},
}

@article{pmid40864401,
  title = {Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.},
  author = {Stern A, Linial M},
  journal = {Geroscience},
  year = {2026},
  pmid = {40864401},
  doi = {doi: 10.1007/s11357-025-01828-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/40864401/},
}

@article{pmid40886963,
  title = {Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasis-Associated Atherosclerosis by Inducing Mitochondrial Dysfunction in Aortic Endothelial Cells.},
  author = {Zhu L, Du L, Wu J, Ding D, Wang J et al.},
  journal = {J Invest Dermatol},
  year = {2026},
  pmid = {40886963},
  doi = {doi: 10.1016/j.jid.2025.05.041},
  url = {https://pubmed.ncbi.nlm.nih.gov/40886963/},
}

@article{pmid41101204,
  title = {Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsules achieves effective combinatorial treatment of glioblastoma.},
  author = {Sang Y, Cao Y, Li S, Quan Y, Wang S et al.},
  journal = {Biomaterials},
  year = {2026},
  pmid = {41101204},
  doi = {doi: 10.1016/j.biomaterials.2025.123785},
  url = {https://pubmed.ncbi.nlm.nih.gov/41101204/},
}

@article{pmid41445196,
  title = {Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.},
  author = {Lin Z, Xiong J, Zhang F, Zhang H, Zhu M et al.},
  journal = {Mol Ther},
  year = {2026},
  pmid = {41445196},
  doi = {doi: 10.1016/j.ymthe.2025.12.035},
  url = {https://pubmed.ncbi.nlm.nih.gov/41445196/},
}

@article{pmid41531227,
  title = {Menopause, cognition, and Alzheimer's disease risk.},
  author = {Samudra N, Vemuri M, Weitlauf J},
  journal = {Curr Opin Obstet Gynecol},
  year = {2026},
  pmid = {41531227},
  doi = {doi: 10.1097/GCO.0000000000001087},
  url = {https://pubmed.ncbi.nlm.nih.gov/41531227/},
}

@article{pmid41594643,
  title = {Epigenetic Dysregulation in Neurodegeneration: The Role of Histone Deacetylases and Emerging Inhibitor Strategies.},
  author = {Pawar Y, Kopranovic A, C S R, Meyer-Almes FJ},
  journal = {Biomolecules},
  year = {2026},
  pmid = {41594643},
  doi = {10.3390/biom16010103},
  url = {https://pubmed.ncbi.nlm.nih.gov/41594643/},
}

@article{pmid41772312,
  title = {Zinc finger proteins (ZFPs) in health and disease.},
  author = {["Zhao Z", "Huang K", "Liao Z", "Chen B", "Chen J", "Mei Z"]},
  journal = {Molecular biomedicine},
  year = {2026},
  pmid = {41772312},
  doi = {10.1186/s43556-026-00413-8},
}

@article{pmid41867029,
  title = {Can we refute a role for infections in Alzheimer's disease pathogenesis?},
  author = {Chatila ZK, Duggan MR, Silberberg E, Fernandez J, Auber LA, Bradshaw EM, Schultek NM},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2026},
  pmid = {41867029},
  doi = {10.1002/alz.71288},
  url = {https://pubmed.ncbi.nlm.nih.gov/41867029/},
}

@article{pmid41890452,
  title = {Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzheimer's Disease Neurodegeneration: A Systematic Review.},
  author = {Arriaga P, Vianna K, Montez C, Panariello B, Tran S, Rodrigues D, Porto Barboza E},
  journal = {Cureus},
  year = {2026},
  pmid = {41890452},
  doi = {10.7759/cureus.104127},
  url = {https://pubmed.ncbi.nlm.nih.gov/41890452/},
}

@article{pmid41895266,
  title = {Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.},
  author = {Delivanoglou N, Todd KT, Almeida F, Rego S, Changavi A, Spajer M, Ayuso VE, Pinho-Correia LM, Sanchez G, das Neves SP, Barber MJ, Schrader R, Sacilotto P, Martens YA, Heckman MG, Bu G, Tanzi RE, Thomas JL, Fryer JD, Oliveira TG, Shekhar K, Da Mesquita S},
  journal = {Neuron},
  year = {2026},
  pmid = {41895266},
  doi = {10.1016/j.neuron.2026.02.030},
  url = {https://pubmed.ncbi.nlm.nih.gov/41895266/},
}

@article{pmid41897333,
  title = {Alirocumab Attenuated Plaque Inflammation and PCSK9-Induced Proinflammatory Signalling in M1 Macrophages Independently of Lipid Lowering.},
  author = {Espadas C, Soto-Catalán M, Romero-Cote M, Kavanagh M, Herrero-Del Real I, Ortega-Hernández A, Lumpuy-Castillo J, Gómez-Garre D, Egido J, Tuñón J, Gómez-Guerrero C, Lorenzo Ó},
  journal = {Biomolecules},
  year = {2026},
  pmid = {41897333},
  doi = {10.3390/biom16030397},
  url = {https://pubmed.ncbi.nlm.nih.gov/41897333/},
}

@article{pmid41899281,
  title = {Alzheimer's Disease: From Pathogenesis to Emerging Therapeutic Targets.},
  author = {Takahashi T, Muguruma K},
  journal = {Journal of clinical medicine},
  year = {2026},
  pmid = {41899281},
  doi = {10.3390/jcm15062357},
  url = {https://pubmed.ncbi.nlm.nih.gov/41899281/},
}

@article{pmid41902331,
  title = {TRIM47 Promotes Atherosclerosis by Activating NF-κB Signaling via IκBα Ubiquitination.},
  author = {Qin X, Luo J, Yuan Y, Liu B, Zhang X, Zhang Y, Fang Y, Wei Y},
  journal = {Drug development research},
  year = {2026},
  pmid = {41902331},
  doi = {10.1002/ddr.70264},
  url = {https://pubmed.ncbi.nlm.nih.gov/41902331/},
}

@article{pmid41905188,
  title = {Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease.},
  author = {Cetindag AC, Schipke CG, Esselmann H, Kruse N, Wiltfang J, Schneider A, Fliessbach K, Miklitz C, Maier F, Buerger K, Janowitz D, Ewers M, Stöcklein S, Perneczky R, Rauchmann BS, Kurz C, Teipel S, Kilimann I, Goerss D, Laske C, Sodenkamp S, Najafpour E, Wagner M, Roeske S, Frommann I, Stark M, Brosseron F, Ramirez A, Kleineidam L, Priller J},
  journal = {The journal of prevention of Alzheimer's disease},
  year = {2026},
  pmid = {41905188},
  doi = {10.1016/j.tjpad.2026.100544},
  url = {https://pubmed.ncbi.nlm.nih.gov/41905188/},
}

@article{pmid41912201,
  title = {Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 and Beta-Amyloid.},
  author = {Sabry HH, Kadhum BQ, Abdulmohsin GN, El-Ghafar AOA, Mahmoud MM, Shams GM},
  journal = {Dermatology practical & conceptual},
  year = {2026},
  pmid = {41912201},
  doi = {10.5826/dpc.1601a5957},
  url = {https://pubmed.ncbi.nlm.nih.gov/41912201/},
}

@article{pmid41930593,
  title = {Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pathology in mild cognitive impairment.},
  author = {Yoshida K, Saito N, Takahashi R, Ando S, Kashibayashi T et al.},
  journal = {J Alzheimers Dis},
  year = {2026},
  pmid = {41930593},
  doi = {doi: 10.1177/13872877261437135},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930593/},
}

@article{pmid41930933,
  title = {UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylation and Degradation of NLRP3.},
  author = {Ding SK},
  journal = {Immunol Invest},
  year = {2026},
  pmid = {41930933},
  doi = {doi: 10.1080/08820139.2026.2651753},
  url = {https://pubmed.ncbi.nlm.nih.gov/41930933/},
}

@article{pmid39622049,
  title = {A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together.},
  author = {Liu Y, Sun X, Liu Q, Han C, Rao Y},
  journal = {Journal of the American Chemical Society},
  year = {2025},
  pmid = {39622049},
  doi = {10.1021/jacs.4c11930},
  url = {https://pubmed.ncbi.nlm.nih.gov/39622049/},
}

@article{pmid39897109,
  title = {Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation.},
  author = {["Ibrahim S", "Khan M", "Noreen S", "Firdous S", "Khurram I", "Rehman R", "Javed M", "Ali Q"]},
  journal = {Cytotechnology},
  year = {2025},
  pmid = {39897109},
  doi = {10.1007/s10616-025-00716-8},
}

@article{pmid39996715,
  title = {From Genetics to Neuroinflammation: The Impact of ApoE4 on Microglial Function in Alzheimer's Disease.},
  author = {["Dias D", "Portugal C", "Relvas J", "Socodato R"]},
  journal = {Cells},
  year = {2025},
  pmid = {39996715},
  doi = {10.3390/cells14040243},
}

@article{pmid40324952,
  title = {Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology.},
  author = {["Baker A", "Ho A", "Itzhaki L", "Fruk L"]},
  journal = {Angewandte Chemie (International ed. in English)},
  year = {2025},
  pmid = {40324952},
  doi = {10.1002/anie.202503958},
}

@article{pmid40348076,
  title = {PROTAC 2.0: Expanding the frontiers of targeted protein degradation.},
  author = {["Cornu M", "Lemaitre T", "Kieffer C", "Voisin-Chiret A"]},
  journal = {Drug discovery today},
  year = {2025},
  pmid = {40348076},
  doi = {10.1016/j.drudis.2025.104376},
}

@article{pmid40756370,
  title = {Liver-targeted degradation of BRD4 reverses hepatic fibrosis and enhances metabolism in murine models.},
  author = {["Yuan S", "Nisar A", "Chen C", "Dong X", "Pan Y", "Zi M", "Wang Q", "Khan S", "Guo Y", "Zhang X"]},
  journal = {Theranostics},
  year = {2025},
  pmid = {40756370},
  doi = {10.7150/thno.113852},
}

@article{pmid40935176,
  title = {Covalent inhibitors in Parkinson's disease: Molecular targeting strategies for neuroprotective intervention.},
  author = {["Mohan D", "Venkatesan R", "Kandy A", "Muthu S", "Jayaram S", "Baskaran R", "Pethappachetty P", "Selvaraj D"]},
  journal = {Molecular and cellular neurosciences},
  year = {2025},
  pmid = {40935176},
  doi = {10.1016/j.mcn.2025.104037},
}

@article{pmid40940201,
  title = {E3 ubiquitin ligases in signaling, disease, and therapeutics.},
  author = {Ebadi P, Stratton CM, Olsen SK},
  journal = {Trends in biochemical sciences},
  year = {2025},
  pmid = {40940201},
  doi = {10.1016/j.tibs.2025.07.009},
  url = {https://pubmed.ncbi.nlm.nih.gov/40940201/},
}

@article{pmid40967163,
  title = {Taming hyper-active Cdk5: Disrupting the Cdk5-p25 axis as a therapeutic avenue for neurodegeneration and beyond.},
  author = {["Kamel E", "Alsalamah S", "Khadrawy S", "Ahmed N", "Alkhayl F", "Lamsabhi A"]},
  journal = {Pathology, research and practice},
  year = {2025},
  pmid = {40967163},
  doi = {10.1016/j.prp.2025.156234},
}

@article{pmid37805344,
  title = {The cell biology of APOE in the brain.},
  author = {Windham IA, Cohen S},
  journal = {Trends Cell Biol},
  year = {2024},
  pmid = {37805344},
  doi = {10.1016/j.tcb.2023.09.004},
  url = {https://pubmed.ncbi.nlm.nih.gov/37805344},
}

@article{pmid37995685,
  title = {Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.},
  author = {Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M},
  journal = {Neuron},
  year = {2024},
  pmid = {37995685},
  doi = {10.1016/j.neuron.2023.10.023},
  url = {https://pubmed.ncbi.nlm.nih.gov/37995685},
}

@article{pmid38671323,
  title = {Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.},
  author = {["Theobald H", "Bejarano D", "Katzmarski N", "Haub J", "Schulte-Schrepping J", "Yu J", "Bassler K", "Ament A", "Osei-Sarpong C", "Piattini F"]},
  journal = {Nature immunology},
  year = {2024},
  pmid = {38671323},
  doi = {10.1038/s41590-024-01830-z},
}

@article{pmid38685916,
  title = {Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?},
  author = {["Kuemper S", "Cairns A", "Birchall K", "Yao Z", "Large J"]},
  journal = {Frontiers in molecular neuroscience},
  year = {2024},
  pmid = {38685916},
  doi = {10.3389/fnmol.2024.1370509},
}

@article{pmid38735056,
  title = {Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.},
  author = {["Kotredes K", "Pandey R", "Persohn S", "Elderidge K", "Burton C", "Miner E", "Haynes K", "Santos D", "Williams S", "Heaton N"]},
  journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year = {2024},
  pmid = {38735056},
  doi = {10.1002/alz.13828},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Translational neurodegeneration},
  year = {2024},
  pmid = {39232848},
  doi = {10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid39232848,
  title = {Updates in Alzheimer's disease: from basic research to diagnosis and therapies.},
  author = {Liu E, Zhang Y, Wang JZ},
  journal = {Transl Neurodegener},
  year = {2024},
  pmid = {39232848},
  doi = {doi: 10.1186/s40035-024-00432-x},
  url = {https://pubmed.ncbi.nlm.nih.gov/39232848/},
}

@article{pmid39344427,
  title = {Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B.},
  author = {["Wilms G", "Schofield K", "Maddern S", "Foley C", "Shaw Y", "Smith B", "Basantes L", "Schwandt K", "Babendreyer A", "Chavez T"]},
  journal = {Journal of medicinal chemistry},
  year = {2024},
  pmid = {39344427},
  doi = {10.1021/acs.jmedchem.4c01130},
}

@article{pmid39487455,
  title = {Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro.},
  author = {["Digiovanni S", "Lorenzati M", "Bianciotto O", "Godel M", "Fontana S", "Akman M", "Costamagna C", "Couraud P", "Buffo A", "Kopecka J"]},
  journal = {Fluids and barriers of the CNS},
  year = {2024},
  pmid = {39487455},
  doi = {10.1186/s12987-024-00590-0},
}

@article{pmid39488207,
  title = {Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.},
  author = {Lu P, Cheng Y, Xue L, Ren X, Xu X, Chen C, Cao L, Li J, Wu Q, Sun S, Hou J, Jia W, Wang W, Ma Y, Jiang Z, Li C, Qi X, Huang N, Han T},
  journal = {Cell},
  year = {2024},
  pmid = {39488207},
  doi = {10.1016/j.cell.2024.10.015},
  url = {https://pubmed.ncbi.nlm.nih.gov/39488207/},
}

@article{pmid39660628,
  title = {Session 5: Protein Degraders.},
  author = {["Palyada K", "Hukkanen R", "Leuenroth-Quinn S", "Vitsky A", "Peterson R", "Stamp K", "Hoover C", "Volak L"]},
  journal = {Toxicologic pathology},
  year = {2024},
  pmid = {39660628},
  doi = {10.1177/01926233241300452},
}

@article{pmid37101169,
  title = {Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera.},
  author = {["Tseng Y", "Lu P", "Lee C", "He R", "Huang Y", "Tseng Y", "Cheng T", "Huang J", "Fang J"]},
  journal = {Journal of biomedical science},
  year = {2023},
  pmid = {37101169},
  doi = {10.1186/s12929-023-00921-7},
}

@article{pmid37221560,
  title = {An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele.},
  author = {["Meuret C", "Hu Y", "Smadi S", "Bantugan M", "Xian H", "Martinez A", "Krauss R", "Ma Q", "Nedelkov D", "Yassine H"]},
  journal = {Alzheimer's research & therapy},
  year = {2023},
  pmid = {37221560},
  doi = {10.1186/s13195-023-01239-0},
}

@article{pmid37279091,
  title = {Near-Infrared-Activatable PROTAC Nanocages for Controllable Target Protein Degradation and On-Demand Antitumor Therapy.},
  author = {["He Q", "Zhou L", "Yu D", "Zhu R", "Chen Y", "Song M", "Liu X", "Liao Y", "Ding T", "Fan W"]},
  journal = {Journal of medicinal chemistry},
  year = {2023},
  pmid = {37279091},
  doi = {10.1021/acs.jmedchem.3c00587},
}

@article{pmid37355598,
  title = {Targeted degradation of ⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technology.},
  author = {Lee J, Sung KW, Bae EJ, Yoon D, Kim D, Lee JS, Park DH, Park DY, Mun SR, Kwon SC, Kim HY, Min JO, Lee SJ, Suh YH, Kwon YT},
  journal = {Molecular neurodegeneration},
  year = {2023},
  pmid = {37355598},
  doi = {10.1186/s13024-023-00630-7},
  url = {https://pubmed.ncbi.nlm.nih.gov/37355598/},
}

@article{pmid37424101,
  title = {Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria.},
  author = {["Mei L", "Chen X", "Wei F", "Huang X", "Liu L", "Yao J", "Chen J", "Luo X", "Wang Z", "Yang A"]},
  journal = {Autophagy},
  year = {2023},
  pmid = {37424101},
  doi = {10.1080/15548627.2023.2234797},
}

@article{pmid37489365,
  title = {Proteolysis-Targeting Chimera (PROTAC) Delivery into the Brain across the Blood-Brain Barrier.},
  author = {["Tashima T"]},
  journal = {Antibodies (Basel, Switzerland)},
  year = {2023},
  pmid = {37489365},
  doi = {10.3390/antib12030043},
}

@article{pmid37947642,
  title = {Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition.},
  author = {["Connolly K", "Margaria J", "Di Biase E", "Cooper O", "Hallett P", "Isacson O"]},
  journal = {Cells},
  year = {2023},
  pmid = {37947642},
  doi = {10.3390/cells12212564},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Maxine R Nelson, Peng Liu, Ayushi Agrawal, Oscar Yip, Jessica Blumenfeld et al.},
  journal = {Nature neuroscience},
  year = {2023},
  pmid = {37957317},
  doi = {10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317},
}

@article{pmid37957317,
  title = {The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.},
  author = {Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J et al.},
  journal = {Nat Neurosci},
  year = {2023},
  pmid = {37957317},
  doi = {doi: 10.1038/s41593-023-01480-8},
  url = {https://pubmed.ncbi.nlm.nih.gov/37957317/},
}

@article{pmid35173167,
  title = {The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.},
  author = {["Ji C", "Kim H", "Lee M", "Heo A", "Park D", "Lim S", "Shin S", "Ganipisetti S", "Yang W", "Jung C"]},
  journal = {Nature communications},
  year = {2022},
  pmid = {35173167},
  doi = {10.1038/s41467-022-28520-4},
}

@article{pmid35722947,
  title = {Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera).},
  author = {["Ji C", "Lee M", "Kim H", "Heo A", "Park D", "Kim Y", "Kim B", "Kwon Y"]},
  journal = {Autophagy},
  year = {2022},
  pmid = {35722947},
  doi = {10.1080/15548627.2022.2091338},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
  author = {Serrano-Pozo A, Das S, Hyman BT},
  journal = {Lancet Neurol},
  year = {2021},
  pmid = {33340485},
  doi = {10.1016/S1474-4422(20)30412-9},
  url = {https://pubmed.ncbi.nlm.nih.gov/33340485},
}

@article{pmid33340485,
  title = {APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.},
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