{"nodes":[{"id":"neurodegeneration","type":"disease"},{"id":"TREM2, TYROBP (DAP12), PLCG2, SYK","type":"gene"},{"id":"C1QA, C1QB, C3, IL1B, NFKB1","type":"gene"}],"edges":[{"source_id":"TREM2, TYROBP (DAP12), PLCG2, SYK","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies","evidence_strength":0.602,"evidence_sources":"[\"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974\", \"{'claim': 'Small molecule agonists of TREM2 reprogram microglia and protect synapses in human AD models', 'pmid': '41648425'}\", \"{'claim': 'Structure-based virtual screening identifies TREM2-targeted small molecules enhancing phagocytosis', 'pmid': '41604675'}\", \"{'claim': 'TREM2 bridging microglia and extracellular microenvironment offers therapeutic prospects', 'pmid': '39608728'}\", \"{'claim': 'Gain-of-function TREM2-T96K mutation increases AD risk by impairing microglial function', 'pmid': '41109213'}\", \"{'claim': 'TREM2 on microglia enables A\\u03b2 phagocytosis and may also facilitate tau clearance', 'pmid': '29784049'}\"]","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-16T17:35:50-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"trem2,_tyrobp_(dap12),_plcg2,_syk","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-15a8468c","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"C1QA, C1QB, C3, IL1B, NFKB1","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: Complement-SASP Amplification Cascade as Mechanistic Link","evidence_strength":0.608,"evidence_sources":"[\"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974\", \"{'claim': 'Young adult microglial deletion of C1Q reduces synapse engulfment and prevents cognitive impairment', 'pmid': '41000995'}\", \"{'claim': 'SASP-mediated mechanisms drive neuroinflammation in AD', 'pmid': '37814508'}\", \"{'claim': 'Complement plays a role in synaptic pruning and neurodegeneration', 'pmid': '34595138'}\", \"{'claim': 'SASP exacerbates synaptic remodeling in tauopathy', 'pmid': '36906076'}\", \"{'claim': 'ANX005 (Annexon) anti-C1Q antibody completed Phase 1 in non-neurological indications', 'pmid': '29202623'}\"]","analysis_id":"SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974","created_at":"2026-04-16T17:43:51-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"c1qa,_c1qb,_c3,_il1b,_nfkb1","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-f4a63646","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":2,"total_nodes":3,"has_more":false}}