{"nodes":[{"id":"tau aggregation","type":"mechanism"},{"id":"Thiamet-G","type":"drug"},{"id":"O-GlcNAcylation","type":"process"},{"id":"OGT","type":"gene","has_wiki":true,"wiki_url":"/wiki/mechanisms-protein-o-glcna-cylation-pathway","wiki_entity":"Protein O-GlcNAcylation Pathway in Neurodegeneration"},{"id":"Bag3","type":"protein"},{"id":"O-GlcNAc","type":"process"},{"id":"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","type":"debate_session_causal"},{"id":"tau propagation","type":"phenotype"},{"id":"tau uptake","type":"mechanism"},{"id":"LRP1","type":"protein","has_wiki":true,"wiki_url":"https://neurowiki.xyz/lrp1","wiki_entity":"LRP1"},{"id":"tau pathology","type":"phenotype"},{"id":"misfolded proteins","type":"mechanism"},{"id":"phosphate","type":"process"},{"id":"heparan sulfate proteoglycans","type":"protein"},{"id":"aggregate-prone proteins","type":"mechanism"},{"id":"Alzheimer's disease","type":"disease"},{"id":"autophagy modulation","type":"process"},{"id":"GPC4/APOE","type":"gene"},{"id":"OGA","type":"protein"},{"id":"neurodegeneration","type":"disease"},{"id":"Bag3-Hsp70 complex","type":"protein"},{"id":"tau phosphorylation","type":"mechanism"},{"id":"processed","type":"sentinel"}],"edges":[{"source_id":"GPC4/APOE","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Conformational Strain Uptake Efficiency","evidence_strength":0.583,"evidence_sources":"[\"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\", \"{'claim': 'A\\u03b2 induces microglial GPC4 and APOE expression leading to increased neuronal tau pathology', 'pmid': '40883746'}\", \"{'claim': 'A\\u03b2 induces GPC4 and APOE in microglia, linking amyloid to tau propagation', 'pmid': '40060520'}\", \"{'claim': 'ApoE3 R136S binds tau and blocks propagation, suppressing neurodegeneration in PSEN1 carriers', 'pmid': '39814008'}\", \"{'claim': '6-O sulfation on heparan sulfate proteoglycans regulates tau internalization', 'pmid': '29686391'}\", \"{'claim': 'Heparan sulfate serves as the mediator between monomeric tau and subsequent intracellular pathway activation', 'pmid': '35040015'}\"]","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-16T03:54:42-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"gpc4_apoe","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-ec79168b","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"O-GlcNAcylation","source_type":"process","target_id":"tau phosphorylation","target_type":"mechanism","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"O-GlcNAcylation","source_type":"process","target_id":"tau aggregation","target_type":"mechanism","relation":"inhibits","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"OGT","source_type":"gene","target_id":"tau pathology","target_type":"phenotype","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"O-GlcNAc","source_type":"process","target_id":"phosphate","target_type":"process","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"LRP1","source_type":"protein","target_id":"tau propagation","target_type":"phenotype","relation":"causes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Bag3","source_type":"protein","target_id":"misfolded proteins","target_type":"mechanism","relation":"clearance_of","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Bag3-Hsp70 complex","source_type":"protein","target_id":"aggregate-prone proteins","target_type":"mechanism","relation":"recognizes","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"autophagy modulation","source_type":"process","target_id":"tau pathology","target_type":"phenotype","relation":"modulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"heparan sulfate proteoglycans","source_type":"protein","target_id":"tau uptake","target_type":"mechanism","relation":"regulates","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Thiamet-G","source_type":"drug","target_id":"OGA","target_type":"protein","relation":"inhibits","evidence_strength":0.9,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.9,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"Alzheimer's disease","source_type":"disease","target_id":"O-GlcNAcylation","target_type":"process","relation":"associated_with","evidence_strength":0.7,"evidence_sources":"{\"debate_session_id\": \"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.332703-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"speculative","trust_score":0.7,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null},{"source_id":"sess_SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","source_type":"debate_session_causal","target_id":"processed","target_type":"sentinel","relation":"causal_extracted","evidence_strength":0.0,"evidence_sources":"{\"task_id\": \"72f50712-2194-475b-86bd-45cb6df6b175\"}","analysis_id":"SDA-2026-04-15-gap-debate-20260410-112730-24052bbe","created_at":"2026-04-28T13:41:14.344200-07:00","edge_type":"debate_extracted","source_canonical_id":null,"target_canonical_id":null,"epistemic_status":"internal","trust_score":0.0,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":13,"total_nodes":23,"has_more":false}}