{"nodes":[{"id":"GBA1","type":"gene","has_wiki":true,"wiki_url":"https://neurowiki.xyz/search?q=GBA1","wiki_entity":"GBA1"},{"id":"TBK1","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-tbk1","wiki_entity":"TBK1"},{"id":"P62","type":"gene","has_wiki":true,"wiki_url":"/wiki/proteins-p62","wiki_entity":"P62"},{"id":"C9ORF72","type":"gene","has_wiki":true,"wiki_url":"/wiki/genes-c9orf72","wiki_entity":"C9ORF72"},{"id":"C1QA, C1QB, C3, IL1B","type":"gene"},{"id":"neurodegeneration","type":"disease","has_wiki":true,"wiki_url":"/entity/Neurodegeneration","wiki_entity":"Neurodegeneration"},{"id":"TFEB","type":"gene","has_wiki":true,"wiki_url":"https://neurowiki.xyz/search?q=TFEB","wiki_entity":"TFEB"},{"id":"TFEB, MTOR","type":"gene"}],"edges":[{"source_id":"C1QA, C1QB, C3, IL1B","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors","evidence_strength":0.61,"evidence_sources":"[\"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88\", \"{'claim': 'SASP-Mediated Complement Cascade Amplification is an established mechanism in ALS', 'pmid': '32719333'}\", \"{'claim': 'VCP-mutant astrocytes exhibit hypoxia response activation', 'pmid': '41349534'}\", \"{'claim': 'HIF-1\\u03b1 is a master transcriptional regulator of inflammatory genes including cytokines and complement components', 'pmid': '32719333'}\", \"{'claim': 'Complement C1Q and C3 are elevated in ALS and implicated in synaptic dysfunction', 'pmid': '32719333'}\", \"{'claim': 'Established SOD1 astrocyte neurotoxicity model provides mechanistic template', 'pmid': '32719333'}\"]","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","created_at":"2026-04-14T00:25:06-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"c1qa,_c1qb,_c3,_il1b","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-a9f2570b","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}"},{"source_id":"TFEB, MTOR","source_type":"gene","target_id":"neurodegeneration","target_type":"disease","relation":"promoted: TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis","evidence_strength":0.575,"evidence_sources":"[\"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88\", \"{'claim': 'VCP maintains lysosomal homeostasis and TFEB activity in skeletal muscle', 'pmid': '30654731'}\", \"{'claim': 'VCP deficiency causes accumulation of large LAMP-1 positive vesicles (autolysosomes)', 'pmid': '20104022'}\", \"{'claim': 'TFEB regulates lysosomal gene expression and autophagy flux', 'pmid': '30654731'}\", \"{'claim': 'VCP mutations impair autophagosome-lysosome fusion', 'pmid': '20104022'}\", \"{'claim': 'Trehalose is in Phase 3 ALS trial (NCT05136885)', 'pmid': None}\"]","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","created_at":"2026-04-14T00:33:06-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"tfeb,_mtor","target_canonical_id":"ent-rese-6f3dc74d","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-810ec0eb","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}"},{"source_id":"C9ORF72","source_type":"gene","target_id":"TFEB","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-810ec0eb","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"C9Orf72","target_canonical_id":"ent-gene-72ca22d2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}"},{"source_id":"GBA1","source_type":"gene","target_id":"TFEB","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-810ec0eb","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"ent-gene-55fa8e24","target_canonical_id":"ent-gene-72ca22d2","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}"},{"source_id":"P62","source_type":"gene","target_id":"TBK1","target_type":"gene","relation":"co_discussed","evidence_strength":0.4,"evidence_sources":"hypothesis:h-810ec0eb","analysis_id":"SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88","created_at":"2026-04-16T18:27:54.037460-07:00","edge_type":"hypothesis_cooccurrence","source_canonical_id":"p62","target_canonical_id":"ent-gene-fbf68727","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":null,"trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}"}],"pagination":{"limit":5000,"offset":0,"total_edges":5,"total_nodes":8,"has_more":false}}