{"nodes":[{"id":"MFSD2A (SLC59A1)","type":"gene"},{"id":"neuropharmacology","type":"disease"}],"edges":[{"source_id":"MFSD2A (SLC59A1)","source_type":"gene","target_id":"neuropharmacology","target_type":"disease","relation":"promoted: MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant Pro-Resolving Prodrugs","evidence_strength":0.552,"evidence_sources":"[\"SDA-2026-04-12-gap-debate-20260410-113110-2059f65f\", \"{'claim': 'MFSD2A is exclusively expressed in BBB endothelium and transports DHA as LPC in a sodium-dependent mechanism; Mfsd2a-knockout mice show marked hippocampal DHA depletion, neuronal loss, and cognitive deficits', 'pmid': '24828044'}\", \"{'claim': 'MFSD2A-transported lipids establish a unique endothelial lipid composition that suppresses caveolae vesicle formation, meaning MFSD2A activity is the dominant lipid influx pathway and modulates the transcytotic landscape simultaneously', 'pmid': '28416077'}\", \"{'claim': 'Aging significantly reduces MFSD2A protein expression in brain microvascular endothelium, with 12- and 24-month-old mice showing significantly impaired [14C]DHA brain uptake versus 2-month-old controls', 'pmid': '36795730'}\", \"{'claim': 'Circulating LPC is the preferred carrier of PUFAs across the BBB via MFSD2A; DHA supplementation in triglyceride form fails in clinical trials while LPC-DHA bioavailability to brain is superior', 'pmid': '32190891'}\", \"{'claim': \\\"SPMs including MaR1, RvD1, and NPD1 show compelling preclinical evidence for Alzheimer's disease neuroinflammation resolution but lack CNS delivery strategies\\\", 'pmid': '32806612'}\"]","analysis_id":"SDA-2026-04-12-gap-debate-20260410-113110-2059f65f","created_at":"2026-04-13T07:04:29-07:00","edge_type":"promoted_hypothesis","source_canonical_id":"mfsd2a_(slc59a1)","target_canonical_id":"neuropharmacology","epistemic_status":"speculative","trust_score":null,"confidence_interval":null,"trust_computed_at":null,"id":"promoted-h-0b5a6761","trust_confidence_low":0.3,"trust_confidence_high":0.7,"trust_computation_factors":"{}","causal_quality_scorecard":null}],"pagination":{"limit":5000,"offset":0,"total_edges":1,"total_nodes":2,"has_more":false}}