{"gaps":[{"gap_id":"gap-debate-20260417-033236-0fe26d91","title":"Does C1q function differ based on subcellular localization or binding partner identity?","status":"open","contributors":74,"direct_total":9412.330507585943,"match_total":8000.0},{"gap_id":"gap-debate-20260412-094638-cd9ef05d","title":"Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to drive TNT formation?","status":"investigating","contributors":45,"direct_total":2454.130663967274,"match_total":2500.0},{"gap_id":"gap-20260416-121711","title":"How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve signaling in Parkinson disease","status":"investigating","contributors":48,"direct_total":1075.533797231627,"match_total":1000.0},{"gap_id":"gap-debate-20260410-074954-95036b06","title":"How do tissue-specific chaperone networks determine differential vulnerability to the same protein misfolding variant?","status":"open","contributors":7,"direct_total":235.0,"match_total":1152.8200000000002},{"gap_id":"gap-ferroptosis-mnd-768eaeba1be3","title":"Ferroptosis in ALS and Motor Neuron Disease: GPX4, Lipid Peroxidation, and Iron Chelation Therapies","status":"open","contributors":51,"direct_total":675.5680893638892,"match_total":500.0},{"gap_id":"gap-epigenetic-comparative-ad-pd-als","title":"Comparative epigenetic signatures: DNA methylation age acceleration and histone modifications across AD, PD, and ALS","status":"open","contributors":51,"direct_total":616.4141542378206,"match_total":500.0},{"gap_id":"gap-pubmed-20260412-094853-199f4f1b","title":"How does the intron-retained RNA isoform mechanistically reduce glucocerebrosidase protein levels and activity?","status":"open","contributors":49,"direct_total":552.5553255015272,"match_total":500.0},{"gap_id":"gap-pubmed-20260411-093924-7330920b","title":"How does engineered C. butyricum cross the blood-brain barrier to directly bind GLP-1 receptors?","status":"investigating","contributors":47,"direct_total":514.311273837802,"match_total":500.0}],"total_gaps":8,"total_direct":15535.843811725883,"total_match":14652.82}