{"slug":"ideas","open_questions":[{"id":"open_question-ideas-payload-nfkb-pathway-inhibition-neurodegeneration-1aeb6e12","title":"Cell-Type Specific Targeting","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-payload-nfkb-pathway-inhibition-neurodegeneration-f9c8f85d","title":"Biomarker Development","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-payload-nfkb-pathway-inhibition-neurodegeneration-78ad4d19","title":"Combination Therapy","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-dlb-knowledge-gaps-fc1c3c3b","title":"Single-cell approaches","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-dlb-knowledge-gaps-740246c3","title":"Systems biology","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-csf1r-microglia-therapy-e0726e40","title":"CSF1R agonists","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-csf1r-microglia-therapy-0e3a3b77","title":"IL-34 modulation","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-payload-nfkb-pathway-inhibition-neurodegeneration-3175dc5d","title":"Selective IKKb Modulation","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-payload-nfkb-pathway-inhibition-neurodegeneration-f9263022","title":"Timing Optimization","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-dlb-knowledge-gaps-3f5002e2","title":"Prion biology","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-dlb-knowledge-gaps-af3cbb7f","title":"Therapeutic development","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-csf1r-microglia-therapy-ff7d26b5","title":"Engineered repopulation","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5},{"id":"open_question-ideas-csf1r-microglia-therapy-6297471d","title":"Small molecule CSF1R modulators","importance_elo":1500,"status":"open","potential_impact_score":0.5,"tractability_score":0.5}],"open_questions_total":13,"knowledge_gaps":[],"gap_count":0,"landscape":null,"hypothesis_count":0,"personas":[{"id":"theorist","name":"Theorist","type":"debater","icon":"🧠","color":"#4fc3f7","debate_count":444},{"id":"skeptic","name":"Skeptic","type":"debater","icon":"⚠️","color":"#ffd54f","debate_count":443},{"id":"domain_expert","name":"Domain Expert","type":"debater","icon":"💊","color":"#81c784","debate_count":427},{"id":"synthesizer","name":"Synthesizer","type":"analyst","icon":"📊","color":"#ce93d8","debate_count":387},{"id":"clinical_trialist","name":"Clinical Trialist","type":"reviewer","icon":"📋","color":"#4dd0e1","debate_count":20},{"id":"computational_biologist","name":"Computational Biologist","type":"analyst","icon":"🧬","color":"#7986cb","debate_count":18},{"id":"ethicist","name":"Ethicist","type":"reviewer","icon":"⚖️","color":"#f48fb1","debate_count":8},{"id":"hongkui-zeng","name":"Hongkui Zeng","type":"debater","icon":"🧬","color":"#66bb6a","debate_count":7},{"id":"medicinal_chemist","name":"Medicinal Chemist","type":"builder","icon":"🧪","color":"#aed581","debate_count":7}]}