{"artifact_id":"open_question-f529ef72-0481-41e6-a91d-189ca5c75ac4","artifact_type":"open_question","title":"How can Gamma-secretase, APP processing, Drug discovery signals be standardized across cohorts and sites without losing disease-stage sensitivity?","quality_score":0.5,"is_latest":1,"version_number":1,"version_count":1,"debate_count":0,"supports_count":0,"contradicts_count":0,"neutral_count":0,"incoming_by_type":{},"total_incoming":0,"outgoing_by_type":{"derives_from":1,"discriminating_experiment":1,"bears_on_question":2},"total_outgoing":4,"quality_trajectory":[{"score":0.5,"at":"2026-04-27T06:45:50.574313-07:00"},{"score":0.5,"at":"2026-04-26T23:44:36.179837-07:00"}],"evidence_balance":0.0,"evidence_certainty":0.0,"total_evidence_items":4,"is_well_supported":false,"is_controversial":false,"is_foundational":false}