{"artifact":{"id":"open_question-f529ef72-0481-41e6-a91d-189ca5c75ac4","artifact_type":"open_question","entity_ids":"[\"researchers\"]","title":"How can Gamma-secretase, APP processing, Drug discovery signals be standardized across cohorts and sites without losing disease-stage sensitivity?","quality_score":0.5,"created_by":"backfill_open_questions","provenance_chain":"[]","content_hash":"b6e5b0c8c54c49fdf979da246e1bf7076275451b5c54bc8493dbe5d1b3008e4b","metadata":{"status":"open","_origin":{"url":null,"type":"internal","tracked_at":"2026-04-26T03:29:33.729573"},"field_tag":"researchers","source_id":"researchers-michael-wolfe","sub_field":"michael-wolfe","source_kind":"wiki","question_hash":"c9ffd85e84cff9617e77da4ebf3f1f75ef5847509f00a8fbdf699b67ae16453f","question_text":"How can Gamma-secretase, APP processing, Drug discovery signals be standardized across cohorts and sites without losing disease-stage sensitivity?","importance_elo":1500,"_schema_version":1,"evidence_summary":"Extracted from wiki page researchers-michael-wolfe","evidence_xref_at":"2026-04-27T13:45:50.559082+00:00","tractability_score":0.5,"potential_impact_score":0.5},"created_at":"2026-04-25T20:29:33.729706-07:00","updated_at":"2026-04-25T20:29:33.729706-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-25T20:29:33.729706-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ce938a58-28e7-4609-bda9-2e556bd1ee72","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"backfill_open_questions"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-researchers-michael-wolfe","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"target_artifact_id":"hypothesis-h-aging-h7-prs-aging-convergence","link_type":"bears_on_question","strength":0.45,"evidence":"{\"confidence\": 0.45, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"discriminating_experiment","strength":0.55,"evidence":"{\"confidence\": 0.55, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"bears_on_question","strength":0.4,"evidence":"{\"confidence\": 0.4, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"incoming_links":[],"current_artifact_id":"open_question-f529ef72-0481-41e6-a91d-189ca5c75ac4","is_canonical":true,"supersede_chain":["open_question-f529ef72-0481-41e6-a91d-189ca5c75ac4"]}