| #1 |
AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue responses |
PRKAA1 |
0.673 |
$0.67 |
| Engineering astrocytes with constitutively active AMPK sensors will make them hyperresponsive to neuronal metabolic distress signals, triggering rapid mitochondrial transfer before irreversible neuron... |
| #2 |
Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enhancement |
COX4I1 |
0.629 |
$0.63 |
| Targeted near-infrared photobiomodulation will upregulate COX4 activity in astrocytic mitochondria, increasing their ATP production capacity and simultaneously enhancing their motility toward neurons ... |
| #3 |
TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle trafficking |
TFAM |
0.585 |
$0.58 |
| Selective overexpression of TFAM in astrocytes will increase their mitochondrial biogenesis, creating a bioenergetic gradient that drives preferential mitochondrial donation to energy-depleted neurons... |
| #4 |
RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery |
RAB27A |
0.531 |
$0.53 |
| Enhancing RAB27A expression in astrocytes will increase packaging of functional mitochondria into extracellular vesicles, creating a novel delivery mechanism that bypasses the need for direct cell-cel... |
| #5 |
CX43 hemichannel engineering enables size-selective mitochondrial transfer |
GJA1 |
0.507 |
$0.51 |
| Modified connexin-43 hemichannels with expanded pore diameters will create selective gates that allow mitochondrial passage while maintaining normal gap junction communication. This approach provides ... |
| #6 |
GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitochondrial transfer |
GAP43 |
0.451 |
$0.45 |
| Overexpression of GAP43 in astrocytes will stabilize tunneling nanotubes and increase the efficiency of mitochondrial transfer to metabolically stressed neurons. This approach leverages the cytoskelet... |
| #7 |
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial delivery |
TRAK1_KIF5A |
0.427 |
$0.43 |
| Engineered fusion proteins combining TRAK1 mitochondrial adaptor domains with enhanced KIF5 motor proteins will create 'super-transporters' that increase the speed and efficiency of mitochondrial move... |