| #1 |
Purinergic P2Y12 Inverse Agonist Therapy |
P2RY12 |
0.638 |
$0.64 |
| Utilize inverse agonists of P2Y12 receptors to constitutively suppress microglial process extension and phagocytic activity specifically at synapses while preserving responses to genuine damage signal... |
| #2 |
Complement C1q Mimetic Decoy Therapy |
C1QA |
0.638 |
$0.64 |
| Engineer synthetic C1q mimetics that bind to synaptic 'eat-me' signals without activating downstream complement cascade, effectively saturating microglial recognition sites and preventing pathological... |
| #3 |
Fractalkine Axis Amplification via CX3CR1 Positive Allosteric Modulators |
CX3CR1 |
0.605 |
$0.60 |
| Develop positive allosteric modulators of CX3CR1 to enhance fractalkine signaling, maintaining microglia in a surveillant, non-phagocytic state and reducing aberrant synaptic pruning.... |
| #4 |
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics |
ANXA1 |
0.543 |
$0.54 |
| Deploy engineered annexin A1 peptides to mask phosphatidylserine 'eat-me' signals on stressed but recoverable synapses, preventing microglial recognition and phagocytosis without triggering apoptotic ... |
| #5 |
TREM2 Conformational Stabilizers for Synaptic Discrimination |
TREM2 |
0.526 |
$0.53 |
| Design small molecule chaperones that stabilize TREM2 in conformations enhancing discrimination between amyloid plaques and healthy synapses, redirecting microglial phagocytosis toward pathological de... |
| #6 |
Optogenetic Microglial Deactivation via Engineered Inhibitory Opsins |
CX3CR1 |
0.514 |
$0.51 |
| Develop cell-type-specific delivery systems for inhibitory opsins targeted to microglia, enabling temporal and spatial control of microglial activity through light-induced hyperpolarization during vul... |
| #7 |
Metabolic Reprogramming via Microglial Glycolysis Inhibition |
HK2 |
0.416 |
$0.42 |
| Selectively inhibit microglial glycolysis to force metabolic reprogramming toward oxidative phosphorylation, promoting anti-inflammatory M2 polarization and reducing ATP availability for synaptic phag... |