| #1 |
Purinergic Signaling Polarization Control |
P2RY1 and P2RX7 |
0.655 |
$0.66 |
| The P2Y1/P2X7 receptor ratio determines astrocyte phenotype fate - high P2Y1:P2X7 promotes A2 while high P2X7:P2Y1 drives A1. Selective P2Y1 activation combined with P2X7 antagonism can therapeuticall... |
| #2 |
Mechanosensitive Ion Channel Reprogramming |
PIEZO1 and KCNK2 |
0.599 |
$0.60 |
| Disease-associated tissue stiffening activates mechanosensitive PIEZO1 channels in astrocytes, locking them into A1 phenotypes through calcium-dependent inflammatory signaling. Selective PIEZO1 inhibi... |
| #3 |
Epigenetic Memory Erasure via TET2 Activation |
TET2 |
0.581 |
$0.58 |
| A1 astrocytes maintain neurotoxic programming through DNA hypermethylation at A2-associated gene loci. Activating TET2 demethylase activity can erase this epigenetic memory, allowing reprogramming to ... |
| #4 |
Lipid Droplet Dynamics as Phenotype Switches |
DGAT1 and SOAT1 |
0.529 |
$0.53 |
| A1 and A2 astrocytes differ in lipid droplet composition and dynamics. A2 astrocytes accumulate cholesteryl esters in lipid droplets that serve as anti-inflammatory reservoirs, while A1 astrocytes hav... |
| #5 |
Circadian Rhythm Entrainment of Reactive Astrocytes |
BMAL1 |
0.519 |
$0.52 |
| Reactive astrocyte subtypes follow circadian oscillations controlled by BMAL1, with A1 phenotypes peaking during rest phases and A2 during active phases. Chronotherapeutic targeting of astrocytic BMAL... |
| #6 |
Mitochondrial Transfer Pathway Enhancement |
MIRO1 |
0.513 |
$0.51 |
| A2 astrocytes can donate healthy mitochondria to neighboring A1 astrocytes via tunneling nanotubes and extracellular vesicles, converting them to neuroprotective phenotypes. Enhancing MIRO1-mediated m... |
| #7 |
Metabolic Switch Targeting for A1→A2 Repolarization |
HK2 |
0.506 |
$0.51 |
| Astrocyte phenotype switching can be controlled by manipulating the hexokinase 2 (HK2)/mitochondrial metabolism axis. Enhancing HK2 activity promotes glycolytic flux that drives A2 neuroprotective pro... |